Assessment of Methotrexate Efficacy in The Treatment of Ectopic Pregnancy

Mehmet Obut; Hanifi Bademkıran; Sedat Akgöl; Bekir Kahveci; İhsan Bağlı; Süleyman Cemil Oğlak; Mehmet Şukru Budak

Assessment of Methotrexate Efficacy in The Treatment of Ectopic Pregnancy

Öz

ABSTRACT

Objective: Our aim in this study was to assess efficacy of single-dose methotrexate (MTX) as medical treatment for ectopic pregnancy (EP) by evaluating the results of patients given this treatment.

Materials and Methods: Between September 2016 and August 2017, the treatment outcomes of EP cases treated with MTX at Gazi Yaşargil Training and Research Hospital of Health Sciences University were evaluated retrospectively.

Results: In total, 126 cases treated for EP were evaluated and 65 cases were included in the study. In cases administered a single dose of MTX, the success rate was 80%, the failure rate was 13.8%, and the emergency surgery rate was 6.2%. The overall success rate of the medical treatment was 90.7% for a second dose of MTX. An unsuccessful result was considered as less than a 15% reduction in the beta-human chorionic gonadotropin (β-hCG) level between 4 and 7 days after single dose MTX administration. In all cases, the rate of emergency surgery after treatment was 9.3%.

Conclusion: In our study, success rates in patients with EP treated with MTX were 80% after a single dose and as high as 90.7% when a second dose was added.

Anahtar Kelimeler

Ectopic pregnancy,medical treatment,methotrexate

References

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Details

Primary Language

English

Subjects

Clinical Sciences

Journal Section

Research Article

Authors

Mehmet Obut ^*
0000-0002-6925-4784
Türkiye

Hanifi Bademkıran This is me
0000-0002-9350-582X
Türkiye

Sedat Akgöl This is me
0000-0001-8609-3049
Türkiye

Bekir Kahveci
0000-0002-8729-1669
Türkiye

İhsan Bağlı This is me
0000-0002-3195-9164
Türkiye

Süleyman Cemil Oğlak This is me
0000-0001-7634-3008
Türkiye

Mehmet Şukru Budak
0000-0001-7328-4188
Türkiye

Publication Date

April 22, 2019

Submission Date

February 17, 2019

Acceptance Date

March 23, 2019

Published in Issue

Year 2019 Volume: 7 Number: 1

IZ

https://izlik.org/JA43RZ99PD

Cite

RIS / Bibtex

APA

Obut, M., Bademkıran, H., Akgöl, S., Kahveci, B., Bağlı, İ., Oğlak, S. C., & Budak, M. Ş. (2019). Assessment of Methotrexate Efficacy in The Treatment of Ectopic Pregnancy. Namık Kemal Tıp Dergisi, 7(1), 25-30. https://izlik.org/JA43RZ99PD

AMA

1.Obut M, Bademkıran H, Akgöl S, et al. Assessment of Methotrexate Efficacy in The Treatment of Ectopic Pregnancy. NKMJ. 2019;7(1):25-30. https://izlik.org/JA43RZ99PD

Chicago

Obut, Mehmet, Hanifi Bademkıran, Sedat Akgöl, et al. 2019. “Assessment of Methotrexate Efficacy in The Treatment of Ectopic Pregnancy”. Namık Kemal Tıp Dergisi 7 (1): 25-30. https://izlik.org/JA43RZ99PD.

EndNote

Obut M, Bademkıran H, Akgöl S, Kahveci B, Bağlı İ, Oğlak SC, Budak MŞ (April 1, 2019) Assessment of Methotrexate Efficacy in The Treatment of Ectopic Pregnancy. Namık Kemal Tıp Dergisi 7 1 25–30.

IEEE

[1]M. Obut et al., “Assessment of Methotrexate Efficacy in The Treatment of Ectopic Pregnancy”, NKMJ, vol. 7, no. 1, pp. 25–30, Apr. 2019, [Online]. Available: https://izlik.org/JA43RZ99PD

ISNAD

Obut, Mehmet - Bademkıran, Hanifi - Akgöl, Sedat - Kahveci, Bekir - Bağlı, İhsan - Oğlak, Süleyman Cemil - Budak, Mehmet Şukru. “Assessment of Methotrexate Efficacy in The Treatment of Ectopic Pregnancy”. Namık Kemal Tıp Dergisi 7/1 (April 1, 2019): 25-30. https://izlik.org/JA43RZ99PD.

JAMA

1.Obut M, Bademkıran H, Akgöl S, Kahveci B, Bağlı İ, Oğlak SC, Budak MŞ. Assessment of Methotrexate Efficacy in The Treatment of Ectopic Pregnancy. NKMJ. 2019;7:25–30.

MLA

Obut, Mehmet, et al. “Assessment of Methotrexate Efficacy in The Treatment of Ectopic Pregnancy”. Namık Kemal Tıp Dergisi, vol. 7, no. 1, Apr. 2019, pp. 25-30, https://izlik.org/JA43RZ99PD.

Vancouver

1.Mehmet Obut, Hanifi Bademkıran, Sedat Akgöl, Bekir Kahveci, İhsan Bağlı, Süleyman Cemil Oğlak, Mehmet Şukru Budak. Assessment of Methotrexate Efficacy in The Treatment of Ectopic Pregnancy. NKMJ [Internet]. 2019 Apr. 1;7(1):25-30. Available from: https://izlik.org/JA43RZ99PD