Akut Myeloid Lösemide CD11b İfadesinin Hemostatik Komplikasyonlar ve Tedaviye Yanıt ile İlişkisi

Öz

Amaç: Çalışmamızda, Akut Myeloid Lösemi (AML) hastalarında CD11b ekspresyonunun klinik seyir ve hastalığın prognozu üzerine etkilerini araştırmayı amaçladık.

Gereç ve yöntem: Trakya bölgesindeki bir üçüncü  basamak hastane olan Trakya Üniversitesi Tıp Fakültesi, Hematoloji Anabilim Dalı'nda 2014-2017 yılları arasında, Dünya Sağlık Örgütü 2016 myeloid maligniteler sınıflamasına göre AML tanısı almış 123 hastanın verileri retrospektif olarak değerlendirildi.

Bulgular: Çalışmamızdaki 123 hastanın 60'ı kadın, 63'ü erkekti. Yaş ortalaması 57.93 idi. CD11b pozitifliği 40 hastada gözlendi. CD 11b pozitifliği olan hastalarda trombosit sayısı anlamlı derecede düşüktü (p = 0.004). Aynı şekilde, D-dimer düzeyleri de CD11b pozitif hasta grubunda daha yüksekti (p = 0.000). Sonuçlar ile ilgili olarak, CD 11b pozitifliği olan hastalarda ilk remisyon indüksiyon tedavisi ile remisyon oranlarının daha düşük olduğu bulundu (p = 0.003). Kaplan Meier sağkalım analizinde; CD-11b pozitifliği ile genel sağkalım arasında bir ilişki bulunamadı (CD 11b pozitif grupta 8.5 ay, negatif grupta 12.1 ay, p: 0.436).

Sonuç: Çalışmamız CD11b ifadesi olan hastaların remisyon indüksiyon kemoterapisi ile daha düşük remisyon oranlarına sahip olduğunu göstermiştir. CD11b, lösemik hücrelerin kemik iliği mikroçevresindeki etkileşimi için gereklidir. CD11b ifadesi AML hastalarında immün kaçış mekanizmalarının bir parçası olabilir.

Anahtar Kelimeler

• Akut Miyeloid Lösemi,CD11b,Akım Sitometri

CD11b Expression in Acute Myeloid Leukemia is Associated with Hemostatic Complications and Response to Treatment

Abstract

Objective: In our study, we aimed to investigate the effects of CD11b expression by myeloblasts on clinical course and prognosis in patients with AML

Materials and methods: Data of 123 patients diagnosed with AML between 2014-2017 in Trakya University Faculty of Medicine, Department of Hematology, a referral tertiary hospital in Trakya Region evaluated in a retrospective manner. Diagnosis of AML is based on WHO 2016 criteria of Myeloid Neoplasms

Results: Of the 123 patients in our study, 60 were female and 63 were male. The mean age was 57.93 years. CD11b positivity observed in 40 patients. Platelet counts were significantly lower in patients with CD 11b positivity (p = 0.004). Likewise, D-dimer levels at presentation were higher in CD11b positive patient group (p = 0.000). Regarding outcomes, patients with CD 11b positivity found to have lower rates of remission with first-line remission induction therapy (p = 0.003).  There was no significant relationship between CD-11b positivity and overall survival with Kaplan Meier survival analysis (8.5 months in CD 11b positive group, 12.1 months in negative group, p: 0.436).

 

Conclusion: Our study showed that patients with CD11b expression had a lower remission rates with remission induction chemotherapy.

Keywords

• Acute Myeloid Leukemia,CD11b,Flow Cytometry

References

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