“ADJUVANT CHEMORADİATİON FOR GASTRIC CANCER: A SINGLE-CENTER EXPERIENCE

Abstract

To evaluate the results of postoperative chemoradiation for stomach cancer. Surgery, with curative aim was the initial therapy for 117 patients. Eligibility criteria for chemoradiation were similar to those of the Intergroup 0116 study. Eighty-three patients (71%) were males and 34 (29%) were females. Their ages ranged from 31 to 78 years (median, 58 years). Surgery was in the shape of total gastrectomy for 46 patients (39%) and 71 patients (61%) had D2 or more dissection. Eight patients (7%) had microscopical disease after surgery. Distribution of patients according to TNM stage was as follows: stage Ib, 6 patients (5%); stage II, 28 patients (24%); stage IIIa, 36 patients (31%); stage IIIb, 26 patients (22%); and stage IV, 21 patients (18%). The median follow-up time was 18 months (ranging from 4 to 89 months). Ninety-five patients (81%) completed the planned chemotherapy cycles, 112 patients (96%) completed radiotherapy and 92 (79%) of them completed chemoradiotherapy. Of the 117 patients, 53 (45%) relapsed, of whom 46 died. Most (41 patients, 35%) of the relapses occurred in distant sites alone. For the 14 patients who developed locoregional relapse, only two had isolated locoregional relapse. OS was 59% at 2 years and 34% at 5 years whereas DFS was 58% at 2 years and 35% at 5 years.

Keywords

• gastric cancer,adjuvant,radiotherapy

“MİDE KANSERİNDE ADJUVAN KEMORADYOTERAPİ: TEK MERKEZ DENEYİMİ

Öz

Amaç, mide kanseri için postoperatif kemoradyoterapi sonuçlarını değerlendirmektir. Toplam yüzonyedi hasta için küratif amaçlı cerrahi başlangıç tedavisiydi. Kemoradyoterapi için uygunluk kriterleri, Intergroup 0116 çalışması ile benzerdi. Seksen üç hasta (%71) erkek, 34 hasta (%29) kadındı. Yaşları 31-78 arasında değişiyordu (ortanca, 58 yaş). Cerrahi 46 hastada (%39) total gastrektomi şeklindeydi ve 71 hastada (%61) D2 veya daha fazla diseksiyon mevcuttu. Sekiz hastada (%7) cerrahi sonrası mikroskopik hastalık vardı. Hastaların TNM evresine göre dağılımı şöyleydi: evre Ib, 6 hasta (%5); evre II, 28 hasta (%24); evre IIIa, 36 hasta (%31); evre IIIb, 26 hasta (%22); ve evre IV, 21 hasta (%18). Medyan takip süresi 18 aydı (4 ila 89 ay arasında). Doksan beş hasta (%81) planlanan kemoterapi döngülerini, 112 hasta (%96) radyoterapiyi, 92 hasta (%79) kemoradyoterapiyi tamamladı. 117 hastanın 53'ü (%45) tekrarladı ve bunların 46'sı öldü. Relapsların çoğu (41 hasta, %35) sadece uzak bölgelerde meydana gelmiştir. Lokasyonel nüks gelişen 14 hasta için sadece ikisinde izole lokasyonel nüks vardı. Genel sağkalım 2 yılda%59 ve 5 yılda%34 iken, hastalıksız sağkalım 2 yılda%58 ve 5 yılda%35 idi.

Anahtar Kelimeler

• Mide kanseri,adjuvant,radyoterapi

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