KORONAVİRÜS HASTALIĞI (COVID-19) İLE İLİŞKİLİ KOAGÜLOPATİ

Year 2020, , 564 - 569, 20.12.2020

Seval Akpınar

https://doi.org/10.37696/nkmj.772162

Abstract

2019 yılı sonunda Çin’in Wuhan eyaletinde ağır akut solunum koronavirus-2 (SARS-CoV-2) olarak adlandırılan, zoonotik kaynaklı yeni bir koronavirus ortaya çıkmıştır. Koronavirus hastalığı 2019 (COVID-2019) olarak adlandırılan infeksiyon Dünya Sağlık Örgütü tarafından global bir pandemi olarak tanımlanmıştır. COVID-19 endotel hasarı, staz ve dolaşan protrombotik faktörlerin artmış düzeylerinin sonucu olan pıhtılaşmanın arttığı bir durumdur. Özellikle yoğun bakım ünitelerinde izlenen hastalarda proflaktik antikoagülan tedaviye rağmen venöz tromboemboli riski artmıştır. Bu derlemede, COVID-19 ilişkili koagülopatinin patofizyoloji, koagülasyon parametreleri, değerlendirme ve yaklaşımına ilişkin güncel verileri özetledik.

Keywords

COVID-19, tromboemboli, tromboz, yaygın damar içi pıhtılaşma

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