OXIDATIVE STRESS PARAMETERS IN PATIENTS WITH MIGRAINE WITHOUT AURA

Year 2020, Volume: 8 Issue: 1, 31 - 35, 20.04.2020

Suat Çakına , Selma Yücel Cemre Çağan Polat Şamil Öztürk

https://doi.org/10.37696/nkmj.589278

Abstract

Objective: Previous research has suggested
that migraine may be associated with increased vulnerability to oxidative
stress. The purpose of this study was to evaluate serum paraoxonase and
arylesterase  activities, thiols levels,
ischemia-modified albumin, the total oxidant status, total antioxidant status,
and oxidative stress index  in patients
with migraine without aura.

Material and Methods:
30 patients (5 males and 25 females) and 30 matched healthy controls (8 males
and 22 females) were enrolled. Serum paraoxonase and arylesterase activities,
thiols levels, ischemia-modified albumin, total antioxidant status, total
oxidant status and oxidative stress index were determined by using the
spectrophotometric method. Statistical analysis was conducted using
Mann–Whitney U test and independent samples t-test, and p <0.05  was considered as
statistically significant.

Results:
Paraoxonase and arylesterase  levels were
significantly lower in the migraine without aura group compared with the
control group (p <0.05).

Conclusion:
Our findings suggested that the paraoxonase and arylesterase levels might be
associated with migraine without aura. In migraine patients, it is recommended
that oxidative stress markers be investigated with a larger population and
these parameters are taken into consideration.

Keywords

Migraine, Oxidative stress, Without aura

Supporting Institution

Scientific Research Projects Coordination Unit of Çanakkale Onsekiz Mart University

Project Number

THD-2018-2509

Thanks

This work was supported by Scientific Research Projects Coordination Unit of Çanakkale Onsekiz Mart University. Project Number: THD-2018-2509

Aurasız Migrenli Hastalarda Oksidatif Stres Parametreleri

Abstract

Amaç:
Önceki araştırmalar, migrenin oksidatif strese karşı artan hassasiyet ile
ilişkili olabileceğini ileri sürmüştür. Bu çalışmanın amacı, aurasız migren
hastalarında serum paraoksonaz ve arilesteraz aktiviteleri, tiyol düzeyleri,
iskemi-modifiye albümin, total oksidan durum, total antioksidan durum ve
oksidatif stres indeksini araştırmaktır.

Materyal ve Metot:
Aurasız migrenli 30 hasta (5 erkek ve 25 kadın) ve 30 sağlıklı kontrol (8 erkek
ve 22 kadın) çalışmaya dahil edildi. Spektrofotometrik yöntemle serum paraoksonaz
ve arilesteraz aktiviteleri, tiyol düzeyleri, iskemi-modifiye albümin, total
antioksidan durum, total oksidan durum ve oksidatif stres indeksi belirlendi.
İstatistiksel analiz Mann-Whitney U testi ve bağımsız örneklem t-testi
kullanılarak yapıldı ve p <0.05 istatistiksel olarak anlamlı kabul edildi.

Bulgular:
Paraoksonaz ve arilesteraz düzeyleri kontrol grubuna göre aurasız migren
grubunda anlamlı derecede düşük bulundu (p <0.05).

Sonuçlar:  Bulgularımız paraoksonaz ve arilesteraz
düzeylerinin aurasız migren ile ilişkili olabileceğini düşündürmektedir. Migren
hastalarında oksidatif stress belirteçlerinin daha büyük bir popülasyona sahip
ve bu parametreler dikkate alınarak araştırılması önerilir.

Keywords

Migren, Oksidatif stres, Aurasız

Project Number

THD-2018-2509

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