Research Article
BibTex RIS Cite

Ethambutol kullanımının optik sinire etkisinin spectral domain optik koherens tomografi ile değerlendirilmesi

Year 2020, Volume: 8 Issue: 1, 43 - 47, 20.04.2020
https://doi.org/10.37696/nkmj.660779

Abstract

Ethambutol kullanımının retina sinir lifi kalınlığına etkisinin etkisinin spectral domain optik koherens tomografi ile değerlendirilmesi
The effect of ethambutol on retinal nerve fiber layer by optical coherence tomography
Amaç: Çalışmanın amacı spectral domain optik koherens tomografi (SD-OCT) kullanarak sağlıklı kişiler ile ethambutol kullanan kişiler arasındaki retina sinir lifi tabakası (RNFL) kalınlığını analiz etmek ve ethambutole bağlı gelişecek optik nöropatinin erken aşamada teşhisi için SD-OCT kullanımını değerlendirmek.
Gereç ve Yöntemler: En az 2 aydır tüberküloz nedeniyle ethambutol kullanan 20 kişinin 40 gözü aynı yaş ve cinsiyetteki 20 sağlıklı kişinin 40 gözü ile RNFL kalınlık parametreleri yönünden karşılaştırıldı. Bütün hastalara tam bir oftalmolojik muayene yapıldı. RNFL’yi etkiyecek hastalığı veya ilaç kullanım öyküsü bulunanlar çalışmaya dahil edilmedi. SD-OCT ile yapılan RNFL analizinde superior, inferior, temporal ve nazal kadran ile maküla kalınlığı değerlendirmeye alındı.
Bulgular ve Sonuç: Ethambutol kullanan hastaların RNFL değerleri: superior 123,12±16,07µm , inferior 131,20±13,26 µm, nazal 79,47±11,54 µm, temporal 78,80±12,82 µm , maküla kalınlığı 266,16±11,94 µm olarak saptandı. Ethambutol kullanan kişiler kontrol grubu ile karşılaştırıldığında istatistiksel olarak anlamlı derecede temporal kadranda kalınlaşma, nazal kadranda incelme saptandı. Superior ve inferior kadranda ve maküla kalınlığında istatiksel olarak anlamlı değişiklik saptanmadı.
Anahtar kelimeler: ethambutol, optik nöropati, OCT , tüberküloz tedavisi
Purpose: To evaluate the retinal nerve fiber layer difference between healthy control groups and patients receiving ethambutol medication using spectral domain optical coherence tomography (OCT)
Material and Methods: 40 eyes of 20 patients using ethambutol for at least 2 months compared with 40 eyes of 20 healthy subjects of the same age and sex. All participants underwent a complete ophthalmologic examination. Patients with a history of disease or drug use affecting RNFL were not included in the study. Superior, inferior, nasal and temporal quadrants and macular thickness were evaluated in SD-OCT.
Results: RNFL thickness values of ethambutol patients were as follows: superior 123,12±16,07µm , inferior 131,20±13,26 µm, nazal 79,47±11,54 µm, temporal 78,80±12,82 µm, macular thickness 266,16±11,94 µm. There was statistically significant increase in temporal quadrant and decrease in nasal quadrant in patients receiving ethambutol medication.

Supporting Institution

Destekleyen kurum bulunmamaktadır.

References

  • KAYNAKLAR 1. Barron G J, Tepper L, Iovine G Ocular toxicity from ethambutol. Am J Ophthalmol. 1974; 77(2):256-260
  • 2. Chan RY, Kwok AK. Ocular toxicity of ethambutol. Hong Kong Med J 2006; 12:56-60
  • 3. Etiz P, Altınsu A.T. A Retrospective Analysis of 232 Newly Diagnosed Cases with Pulmonary tuberculosis, Türk Mikrobiyol Cem Dergisi 2018;48(2):117-124
  • 4. Chuenkongkaew W, Samsen P, Thanasombatsakul N. Ethambutol and optic neuropathy. J Med Assoc Thai 2003:86:622-
  • 5. Schild H Fox. Rapid-onset reversible ocular toxicity from ethambutol therapy. Am J Med. 1991; 90: 404-6.
  • 6. Bıçakçı Ş, Özeren A, Yerdelen D, Sarıca Y. Etambutol Kullanımına Bağlı Optik Nöropati. Türkiye Klinikleri J Med Sci 2005, 25:460-462
  • 7. Kumar A, Sandramouli S, Verma L, Tewari H K, Khosla P K . Ocular ethambutol toxocity is it reversible? Journal of Clinical Neurophthamology, 1993, 13, 15-17
  • 8. Zoumalan CI, Sadun AA, Agarwal M. Optical coherence tomography can measure axonal loss in patients with ethambutol-induced optic neuropathy Graefes Arch Clin Exp Ophthalmol 2005; 243: 410-416. 10.1007/s00417-004-1053-1
  • 9. Sivakumaran P, Harrison AC, Marschner J, et al. Ocular toxicity from ethambutol: a rwview of four cases and recommended precautions. N Z Med J 1998; 111: 428-30.
  • 10. Petri WA Jr. Drugs used in the chemotherapy of tuberculosis, Mycobacterium avium complex disease and leprosy In: Hardman JS, Limbird LE, eds. Goodman & gilman’s The Pharmacological Basis of Therapeutics. 10th ed New York, NY: McGraw-Hill; 2001:1279-1280.
  • 11. Buyske DA, Peets E, Sterling W Pharmacological and biochemical studies on ethambutol in laboratory animals. Ann NY Acad Sci. 1966; 135(2):711-725
  • 12. Cole A, May PM, Williams DR Metal binding by Pharmaceuticals. Part 3. Copper and zinc interactions with isoniazid. Agents Actions. 1983; 1:91-97 13. Sadun AA Acquired mitochondrial impairment as a cause of optic nerve disease . Trans Am Opthalmol Soc. 1998; 96:881-923
  • 14. Mudun A.Nöro-oftalmolojik Hastalıklarda Optik Koherens Tomografi. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 2011;2(1):5-9
  • 15. Ungsoo Kim, Jeong-min Hwang. Early stage ethambutol optic neuropathy: retinal nerve fiber layer and optical coherence tomograph. Europan Journal of Ophthalmol. V 2009; 19(3) : 466-469
  • 16. Chai SJ, Foroozan RD. Decreased retinal nerve fiber layer thickness detected by optical coherence tomography in patients with ethambutol-induced optic neuropathy. Br J Ophthalmol. 2007. July; 91(7): 895-7.
  • 17. Taffner BMP, Mattos FB, Cunha MC, Saraiva FP. The use of optical coherence tomography for the detection of occular toxity by ethambutol. 2018; 13(11)
Year 2020, Volume: 8 Issue: 1, 43 - 47, 20.04.2020
https://doi.org/10.37696/nkmj.660779

Abstract

References

  • KAYNAKLAR 1. Barron G J, Tepper L, Iovine G Ocular toxicity from ethambutol. Am J Ophthalmol. 1974; 77(2):256-260
  • 2. Chan RY, Kwok AK. Ocular toxicity of ethambutol. Hong Kong Med J 2006; 12:56-60
  • 3. Etiz P, Altınsu A.T. A Retrospective Analysis of 232 Newly Diagnosed Cases with Pulmonary tuberculosis, Türk Mikrobiyol Cem Dergisi 2018;48(2):117-124
  • 4. Chuenkongkaew W, Samsen P, Thanasombatsakul N. Ethambutol and optic neuropathy. J Med Assoc Thai 2003:86:622-
  • 5. Schild H Fox. Rapid-onset reversible ocular toxicity from ethambutol therapy. Am J Med. 1991; 90: 404-6.
  • 6. Bıçakçı Ş, Özeren A, Yerdelen D, Sarıca Y. Etambutol Kullanımına Bağlı Optik Nöropati. Türkiye Klinikleri J Med Sci 2005, 25:460-462
  • 7. Kumar A, Sandramouli S, Verma L, Tewari H K, Khosla P K . Ocular ethambutol toxocity is it reversible? Journal of Clinical Neurophthamology, 1993, 13, 15-17
  • 8. Zoumalan CI, Sadun AA, Agarwal M. Optical coherence tomography can measure axonal loss in patients with ethambutol-induced optic neuropathy Graefes Arch Clin Exp Ophthalmol 2005; 243: 410-416. 10.1007/s00417-004-1053-1
  • 9. Sivakumaran P, Harrison AC, Marschner J, et al. Ocular toxicity from ethambutol: a rwview of four cases and recommended precautions. N Z Med J 1998; 111: 428-30.
  • 10. Petri WA Jr. Drugs used in the chemotherapy of tuberculosis, Mycobacterium avium complex disease and leprosy In: Hardman JS, Limbird LE, eds. Goodman & gilman’s The Pharmacological Basis of Therapeutics. 10th ed New York, NY: McGraw-Hill; 2001:1279-1280.
  • 11. Buyske DA, Peets E, Sterling W Pharmacological and biochemical studies on ethambutol in laboratory animals. Ann NY Acad Sci. 1966; 135(2):711-725
  • 12. Cole A, May PM, Williams DR Metal binding by Pharmaceuticals. Part 3. Copper and zinc interactions with isoniazid. Agents Actions. 1983; 1:91-97 13. Sadun AA Acquired mitochondrial impairment as a cause of optic nerve disease . Trans Am Opthalmol Soc. 1998; 96:881-923
  • 14. Mudun A.Nöro-oftalmolojik Hastalıklarda Optik Koherens Tomografi. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 2011;2(1):5-9
  • 15. Ungsoo Kim, Jeong-min Hwang. Early stage ethambutol optic neuropathy: retinal nerve fiber layer and optical coherence tomograph. Europan Journal of Ophthalmol. V 2009; 19(3) : 466-469
  • 16. Chai SJ, Foroozan RD. Decreased retinal nerve fiber layer thickness detected by optical coherence tomography in patients with ethambutol-induced optic neuropathy. Br J Ophthalmol. 2007. July; 91(7): 895-7.
  • 17. Taffner BMP, Mattos FB, Cunha MC, Saraiva FP. The use of optical coherence tomography for the detection of occular toxity by ethambutol. 2018; 13(11)
There are 16 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Orginal Article
Authors

Gül Varan 0000-0002-5732-1986

Ahmet Şahin 0000-0002-0177-8979

Publication Date April 20, 2020
Published in Issue Year 2020 Volume: 8 Issue: 1

Cite

APA Varan, G., & Şahin, A. (2020). Ethambutol kullanımının optik sinire etkisinin spectral domain optik koherens tomografi ile değerlendirilmesi. Namık Kemal Tıp Dergisi, 8(1), 43-47. https://doi.org/10.37696/nkmj.660779
AMA Varan G, Şahin A. Ethambutol kullanımının optik sinire etkisinin spectral domain optik koherens tomografi ile değerlendirilmesi. NKMJ. April 2020;8(1):43-47. doi:10.37696/nkmj.660779
Chicago Varan, Gül, and Ahmet Şahin. “Ethambutol kullanımının Optik Sinire Etkisinin Spectral Domain Optik Koherens Tomografi Ile değerlendirilmesi”. Namık Kemal Tıp Dergisi 8, no. 1 (April 2020): 43-47. https://doi.org/10.37696/nkmj.660779.
EndNote Varan G, Şahin A (April 1, 2020) Ethambutol kullanımının optik sinire etkisinin spectral domain optik koherens tomografi ile değerlendirilmesi. Namık Kemal Tıp Dergisi 8 1 43–47.
IEEE G. Varan and A. Şahin, “Ethambutol kullanımının optik sinire etkisinin spectral domain optik koherens tomografi ile değerlendirilmesi”, NKMJ, vol. 8, no. 1, pp. 43–47, 2020, doi: 10.37696/nkmj.660779.
ISNAD Varan, Gül - Şahin, Ahmet. “Ethambutol kullanımının Optik Sinire Etkisinin Spectral Domain Optik Koherens Tomografi Ile değerlendirilmesi”. Namık Kemal Tıp Dergisi 8/1 (April 2020), 43-47. https://doi.org/10.37696/nkmj.660779.
JAMA Varan G, Şahin A. Ethambutol kullanımının optik sinire etkisinin spectral domain optik koherens tomografi ile değerlendirilmesi. NKMJ. 2020;8:43–47.
MLA Varan, Gül and Ahmet Şahin. “Ethambutol kullanımının Optik Sinire Etkisinin Spectral Domain Optik Koherens Tomografi Ile değerlendirilmesi”. Namık Kemal Tıp Dergisi, vol. 8, no. 1, 2020, pp. 43-47, doi:10.37696/nkmj.660779.
Vancouver Varan G, Şahin A. Ethambutol kullanımının optik sinire etkisinin spectral domain optik koherens tomografi ile değerlendirilmesi. NKMJ. 2020;8(1):43-7.