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Üç Boyutlu Hücre Kültürü Sistemlerine Güncel Yaklaşımlar

Year 2020, Volume: 8 Issue: 1, 84 - 92, 20.04.2020
https://doi.org/10.37696/nkmj.679069

Abstract

İki boyutlu (2B) hücre kültürü, hücre temelli araştırmalar için değerli bir yöntemdir ancak in vivo yanıtlar hakkında öngörülemeyen, yanıltıcı veriler sağlayabilir. Son yirmi yılda, hücresel mikro çevrenin (örneğin hücre dışı matris ve interstisyel sıvı) önemine farkındalık artmıştır. 3B hücre kültürü olarak adlandırılan bu yeni hücre kültürü paradigması hızla popülerlik kazanıyor. 2B'den 3B kültür tekniklerine geçiş, fizyolojik olarak daha uygun doku modellerine doğru önemli bir adımdır. 3B hücre kültürleri farklı amaçlar için faklı teknikler sunar ve gereksinime göre kullanıcıların en uygun modeli seçmeleri gerekir. 3B hücre kültürü sistemleri, kök hücre çalışmaları, ilaç keşifleri, kanser araştırmaları, gen ve protein ifade çalışmaları ve daha birçok karmaşık fizyolojik mekanizmanın aydınlatılabilmesi için bu alanlarda kullanıldığı görülmektedir. İn vitro çalışmalar; 3B hücre kültürlerinin ortaya çıkmasıyla, 2B kültürler ile mümkün olmayan karmaşık etkileşimleri incelemek için üstün yapılar sunarlar.

References

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Year 2020, Volume: 8 Issue: 1, 84 - 92, 20.04.2020
https://doi.org/10.37696/nkmj.679069

Abstract

References

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  • Referans 17. Baker BM, Chen CS. Deconstructing the third dimension–how 3D culture microenvironments alter cellular cues. J Cell Sci. 2012;125(13):3015-3024.
  • Referans 18. Bonnier F, Keating M, Wrobel TP, Majzner K, Baranska M, Garcia-Munoz A, et al. Cell viability assessment using the Alamar blue assay: a comparison of 2D and 3D cell culture models. Toxicology in vitro. 2015;29(1):124-131.
  • Referans 19. Friedl P, Sahai E, Weiss S, Yamada KM. New dimensions in cell migration. Nature reviews Molecular cell biology. 2012;13(11):743.
  • Referans 20. Chitcholtan K, Asselin E, Parent S, Sykes PH, Evans JJ. Differences in growth properties of endometrial cancer in three dimensional (3D) culture and 2D cell monolayer. Experimental cell research. 2013;319(1):75-87.
  • Referans 21. Mabry KM, Payne SZ, Anseth KS. Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype. Biomaterials. 2016;74:31-41.
  • Referans 22. Pineda ET, Nerem RM, Ahsan T. Differentiation patterns of embryonic stem cells in two-versus three-dimensional culture. Cells Tissues Organs. 2013;197(5):399-410. Referans 23. Ji C, Khademhosseini A, Dehghani F. Enhancing cell penetration and proliferation in chitosan hydrogels for tissue engineering applications. Biomaterials. 2011;32(36):9719-9729.
  • Referans 24. Kimlin LC, Casagrande G, Virador VM. In vitro three‐dimensional (3D) models in cancer research: an update. Molecular carcinogenesis. 2013;52(3):167-182.
  • Referans 25. Bott K, Upton Z, Schrobback K, Ehrbar M, Hubbell JA, Lutolf MP, et al. The effect of matrix characteristics on fibroblast proliferation in 3D gels. Biomaterials. 2010;31(32):8454-8464.
  • Referans 26. Gjorevski N, Piotrowski AS, Varner VD, Nelson CM. Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices. Scientific reports. 2015;5:11458.
  • Referans 27. Grinnell F. Fibroblast biology in three-dimensional collagen matrices. Trends in cell biology. 2003;13(5):264-269.
  • Referans 28. Yoshii Y, Waki A, Yoshida K, Kakezuka A, Kobayashi M, Namiki H, et al. The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation. Biomaterials. 2011;32(26):6052-6058.
  • Referans 29. Hakkinen KM, Harunaga JS, Doyle AD, Yamada KM. Direct comparisons of the morphology, migration, cell adhesions, and actin cytoskeleton of fibroblasts in four different three-dimensional extracellular matrices. Tissue Engineering Part A. 2010;17(5-6):713-724.
  • Referans 30. Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, et al. Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proceedings of the National Academy of Sciences. 1998;95(25):14821-14826. Referans 31. Koch TM, Münster S, Bonakdar N, Butler JP, Fabry B. 3D traction forces in cancer cell invasion. PloS one. 2012;7(3):e33476.
  • Referans 32. Steinwachs J, Metzner C, Skodzek K, Lang N, Thievessen I, Mark C, et al. Three-dimensional force microscopy of cells in biopolymer networks. Nature methods. 2016;13(2):171.
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There are 92 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Review
Authors

Elif Polat 0000-0001-6808-5467

Publication Date April 20, 2020
Published in Issue Year 2020 Volume: 8 Issue: 1

Cite

APA Polat, E. (2020). Üç Boyutlu Hücre Kültürü Sistemlerine Güncel Yaklaşımlar. Namık Kemal Tıp Dergisi, 8(1), 84-92. https://doi.org/10.37696/nkmj.679069
AMA Polat E. Üç Boyutlu Hücre Kültürü Sistemlerine Güncel Yaklaşımlar. NKMJ. April 2020;8(1):84-92. doi:10.37696/nkmj.679069
Chicago Polat, Elif. “Üç Boyutlu Hücre Kültürü Sistemlerine Güncel Yaklaşımlar”. Namık Kemal Tıp Dergisi 8, no. 1 (April 2020): 84-92. https://doi.org/10.37696/nkmj.679069.
EndNote Polat E (April 1, 2020) Üç Boyutlu Hücre Kültürü Sistemlerine Güncel Yaklaşımlar. Namık Kemal Tıp Dergisi 8 1 84–92.
IEEE E. Polat, “Üç Boyutlu Hücre Kültürü Sistemlerine Güncel Yaklaşımlar”, NKMJ, vol. 8, no. 1, pp. 84–92, 2020, doi: 10.37696/nkmj.679069.
ISNAD Polat, Elif. “Üç Boyutlu Hücre Kültürü Sistemlerine Güncel Yaklaşımlar”. Namık Kemal Tıp Dergisi 8/1 (April 2020), 84-92. https://doi.org/10.37696/nkmj.679069.
JAMA Polat E. Üç Boyutlu Hücre Kültürü Sistemlerine Güncel Yaklaşımlar. NKMJ. 2020;8:84–92.
MLA Polat, Elif. “Üç Boyutlu Hücre Kültürü Sistemlerine Güncel Yaklaşımlar”. Namık Kemal Tıp Dergisi, vol. 8, no. 1, 2020, pp. 84-92, doi:10.37696/nkmj.679069.
Vancouver Polat E. Üç Boyutlu Hücre Kültürü Sistemlerine Güncel Yaklaşımlar. NKMJ. 2020;8(1):84-92.