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YAYGIN BÜYÜK B HÜCRELİ LENFOMA (YBBHL) TANILI OLGULARIN RETROSPEKTİF DEĞERLENDİRMESİ

Year 2020, Volume: 8 Issue: 3, 383 - 390, 20.12.2020
https://doi.org/10.37696/nkmj.719261

Abstract

ÖZET
Giriş: Yaygın Büyük B Hücreli Lenfoma (YBBHL), tüm agresif lenfomaların yaklaşık %80’ını oluşturup en sık görülen non-Hodgkin lenfomadır. Prognostik açıdan heterojen karakterli olsa da monoklonal antikor rituksimabın tedaviye girmesiyle, sağ kalımda önemli iyileşme sağlanmıştır. Bu çalışmamızda YBBHL tanısı almış hastalarımızın 5 yıllık takip sürecinde yanıt, epidemiyolojik özellikler, progresyonsuz ve toplam sağ kalım analizlerini sunuyoruz.
Method: Çalışmamızda 3 merkezden DLBCL tanılı 160 olgunun demografik verileri, evre, risk grubu, ilk tedavi ve yanıtları, remisyon süreleri, relaps durumları ve görülen yan etkileri kaydedildi. İstatiksel analiz için Package for the Social Sciences (SPSS) 22.0 yazılımı kullanıldı. Sağ kalım değerlendirilmesi Kaplan-Meier analizi ile yapıldı. Sağ kalım üzerine anlamlılık ilişkisi long-rank testi ile saptandı, P değerinin 0.05'ten küçük olduğu analizler istatistiksel olarak anlamlı kabul edildi.
Sonuç: Hastaların tanı anındaki yaş ortalaması 60,75 ± 13,95 bulundu. Yüzdokuz hastada (%68,1) sadece nodal tutulum, 51’inde (%31,9) ise ekstranodal tutulum gözlendi. Erkek hastalarda kadınlara göre ilk tedavi sonrası relaps oranı istatiksel anlamlı olarak yüksek bulundu. Evre ile GSK ve tedavi yanıt arasında bir fark saptanmazken (p=0,140 ve p=0,378), PSK süreleri ile anlamlı fark elde edilmiştir (p=0,038). Ayrıca nodal ve ekstranodal tutulumlu hastaların GSK ve PSK süreleri arasında anlamlı fark saptanmamıştır. Risk değerlendirmesi açısından aaIPI risk grubu arttıkça, ilk tedaviye yanıt oranlarının azaldığı görülmüştür (p=0,031).
Tartışma: Çalışmamızda DLBCL tanılı hastaların popülasyonundaki genel karakteristiği ortaya konulmuş olup risk faktörlerin ise literatür ile karşılaştırıldığında sonuçların benzer olduğu görülmüştür.

References

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  • 12. Abdelhamid T, Samra M, Ramadan H, Mehessin M, Mokhtar N. Clinical prognostic factors of diffuse large B cell non-Hodgkin lymphoma: a retrospective study. J Egypt Natl Canc Inst. 2011;23(1):17-24.
  • 13. Yang S, Yu Y, Jun-Min L, Jian-Qing M, Qiu-Sheng C, Yu C et al. Reassessment of the prognostic factors of international prognostic index (IPI) in the patients with diffuse large B-cell lymphoma in an era of R-CHOP in Chinese population. Ann Hematol. 2009;88(9):863-9.
  • 14. Yoo C, Kim S, Sohn BS, Kim JE, Yoon DH, Huh J et al. Modified number of extranodal involved sites as a prognosticator in R-CHOP-treated patients with disseminated diffuse large B-cell lymphoma. Korean J intern Med. 2010;25(3):301.
  • 15. Gogia A, Das CK, Kumar L, Sharma A, Tiwari A, Sharma MC et al. Diffuse large B-cell lymphoma: An institutional analysis. South Asian J Cancer. 2018;7(3):200.
  • 16. Riihijärvi S, Taskinen M, Jerkeman M, Leppä S. Male gender is an adverse prognostic factor in B‐cell lymphoma patients treated with immunochemotherapy. Eur J Hematol, 2011;86(2):124-8.
  • 17. Jelicic J, Larsen TS, Maksimovic M, Trajcovic G: Available prognostic models for risk stratification of diffuse large B cell lymphoma patients: Systemic review. Crit Rev in Oncol Hemat. [İnternet yayını] 2018 November; 133:1-16. Erişim: https://doi.org/10.1016/j.critrevonc.2018.10.006
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Year 2020, Volume: 8 Issue: 3, 383 - 390, 20.12.2020
https://doi.org/10.37696/nkmj.719261

Abstract

References

  • 1. Morton L.M, Wang SS, Devasa SS, Hartge P, Weisenburger DD and Linet MS. Lymphoma incidence patterns by WHO subtype in the United States. Blood. 2006;107(1):265-76.
  • 2. Swerdlow SH. WHO classification of tumours of haematopoietic and lymphoid tissues (4th ed). Lyon: Swerdlow and Campo, 2008;439.
  • 3. Cheson BD. Role of functional imaging in the management of lymphoma. J Clin Oncol. 2011;29(14):1844-54.
  • 4. Zhou Z, Sehn LH, Rademaker AW, Gordon LI, Lacasce AS, Crosby-Thompson A et al. An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era. Blood. 2014;123(6):837-42.
  • 5. Persky DO, Unger JM, Spier CM, Stea B, LeBlanc M, McCarty MJ et al. Phase II study of rituximab plus three cycles of CHOP and involved-field radiotherapy for patients with limited-stage aggressive B-cell lymphoma: Southwest Oncology Group study 0014. J Clin Oncol. 2008;26(14):2258-63.
  • 6. Juweid ME, Stroobants S, Hoekstra OS, Mottaghy FM, Dietlien M, Guarmazi A et al. Use of positron emission tomography for response assessment of lymphoma: consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma. J Clin Oncol. 2007;25(5):571-8.
  • 7. Elstrom RL, Martin P, Rua SH, Shora TB, Furman RR, Ruan J et al. Autologous stem cell transplant is feasible in very elderly patients with lymphoma and limited comorbidity. Am J Hematol. 2012;87(4):433-5.
  • 8. Coiffier B. Diffuse large cell lymphoma. Current opinion in oncology. 2001;13(5):325-34.
  • 9. Martelli M, Ferreri AJ, Agostinelli C, Di Rocco A, Pfreundschuh M, Pileri SA et al. Diffuse large B-cell lymphoma. Crit Rev in Oncol Hemat. 2013;87(2):146-71.
  • 10. Babu SM, Garg S, Kanakasetty GB, Kuntegowdanahalli LC, Dasappa L, Rao SA. Diffuse large B-cell lymphoma: A retrospective study from a regional care center in South India. Indian J Cancer. 2018;55(1):66.
  • 11. López-Guillermo A, Colomo L, Jiménez M, Bosch F, Villamor N, Arenillas L et al. Diffuse large B-cell lymphoma: clinical and biological characterization and outcome according to the nodal or extranodal primary origin. J Clin Oncol. 2005;23(12):2797-804.
  • 12. Abdelhamid T, Samra M, Ramadan H, Mehessin M, Mokhtar N. Clinical prognostic factors of diffuse large B cell non-Hodgkin lymphoma: a retrospective study. J Egypt Natl Canc Inst. 2011;23(1):17-24.
  • 13. Yang S, Yu Y, Jun-Min L, Jian-Qing M, Qiu-Sheng C, Yu C et al. Reassessment of the prognostic factors of international prognostic index (IPI) in the patients with diffuse large B-cell lymphoma in an era of R-CHOP in Chinese population. Ann Hematol. 2009;88(9):863-9.
  • 14. Yoo C, Kim S, Sohn BS, Kim JE, Yoon DH, Huh J et al. Modified number of extranodal involved sites as a prognosticator in R-CHOP-treated patients with disseminated diffuse large B-cell lymphoma. Korean J intern Med. 2010;25(3):301.
  • 15. Gogia A, Das CK, Kumar L, Sharma A, Tiwari A, Sharma MC et al. Diffuse large B-cell lymphoma: An institutional analysis. South Asian J Cancer. 2018;7(3):200.
  • 16. Riihijärvi S, Taskinen M, Jerkeman M, Leppä S. Male gender is an adverse prognostic factor in B‐cell lymphoma patients treated with immunochemotherapy. Eur J Hematol, 2011;86(2):124-8.
  • 17. Jelicic J, Larsen TS, Maksimovic M, Trajcovic G: Available prognostic models for risk stratification of diffuse large B cell lymphoma patients: Systemic review. Crit Rev in Oncol Hemat. [İnternet yayını] 2018 November; 133:1-16. Erişim: https://doi.org/10.1016/j.critrevonc.2018.10.006
  • 18. Ziepert M, Hasenclever D, Kuhnt E, Glass B, Schmitz C, Pfreundschuh M et al. Standard International prognostic index remains a valid predictor of outcome for patients with aggressive CD20+ B-cell lymphoma in the rituximab era. J Clin Oncol. 2010;28(14):2373-80.
  • 19. Shipp M, Harrington DP, Anderson JR, Armitage JO, Bonadonna G, Brittinger G et al. A predictive model for aggressive non-Hodgkin's lymphoma. The international non-Hodgkin's lymphoma prognostic factors project. N Engl j Med.1993;329:987-94.
There are 19 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Orginal Article
Authors

Atakan Tekinalp

Sinan Demircioğlu 0000-0003-1277-5105

Volkan Karakuş 0000-0001-9178-2850

Özcan Çeneli 0000-0003-2541-1335

Burhan Turgut 0000-0001-5729-0043

Publication Date December 20, 2020
Published in Issue Year 2020 Volume: 8 Issue: 3

Cite

APA Tekinalp, A., Demircioğlu, S., Karakuş, V., Çeneli, Ö., et al. (2020). YAYGIN BÜYÜK B HÜCRELİ LENFOMA (YBBHL) TANILI OLGULARIN RETROSPEKTİF DEĞERLENDİRMESİ. Namık Kemal Tıp Dergisi, 8(3), 383-390. https://doi.org/10.37696/nkmj.719261
AMA Tekinalp A, Demircioğlu S, Karakuş V, Çeneli Ö, Turgut B. YAYGIN BÜYÜK B HÜCRELİ LENFOMA (YBBHL) TANILI OLGULARIN RETROSPEKTİF DEĞERLENDİRMESİ. NKMJ. December 2020;8(3):383-390. doi:10.37696/nkmj.719261
Chicago Tekinalp, Atakan, Sinan Demircioğlu, Volkan Karakuş, Özcan Çeneli, and Burhan Turgut. “YAYGIN BÜYÜK B HÜCRELİ LENFOMA (YBBHL) TANILI OLGULARIN RETROSPEKTİF DEĞERLENDİRMESİ”. Namık Kemal Tıp Dergisi 8, no. 3 (December 2020): 383-90. https://doi.org/10.37696/nkmj.719261.
EndNote Tekinalp A, Demircioğlu S, Karakuş V, Çeneli Ö, Turgut B (December 1, 2020) YAYGIN BÜYÜK B HÜCRELİ LENFOMA (YBBHL) TANILI OLGULARIN RETROSPEKTİF DEĞERLENDİRMESİ. Namık Kemal Tıp Dergisi 8 3 383–390.
IEEE A. Tekinalp, S. Demircioğlu, V. Karakuş, Ö. Çeneli, and B. Turgut, “YAYGIN BÜYÜK B HÜCRELİ LENFOMA (YBBHL) TANILI OLGULARIN RETROSPEKTİF DEĞERLENDİRMESİ”, NKMJ, vol. 8, no. 3, pp. 383–390, 2020, doi: 10.37696/nkmj.719261.
ISNAD Tekinalp, Atakan et al. “YAYGIN BÜYÜK B HÜCRELİ LENFOMA (YBBHL) TANILI OLGULARIN RETROSPEKTİF DEĞERLENDİRMESİ”. Namık Kemal Tıp Dergisi 8/3 (December 2020), 383-390. https://doi.org/10.37696/nkmj.719261.
JAMA Tekinalp A, Demircioğlu S, Karakuş V, Çeneli Ö, Turgut B. YAYGIN BÜYÜK B HÜCRELİ LENFOMA (YBBHL) TANILI OLGULARIN RETROSPEKTİF DEĞERLENDİRMESİ. NKMJ. 2020;8:383–390.
MLA Tekinalp, Atakan et al. “YAYGIN BÜYÜK B HÜCRELİ LENFOMA (YBBHL) TANILI OLGULARIN RETROSPEKTİF DEĞERLENDİRMESİ”. Namık Kemal Tıp Dergisi, vol. 8, no. 3, 2020, pp. 383-90, doi:10.37696/nkmj.719261.
Vancouver Tekinalp A, Demircioğlu S, Karakuş V, Çeneli Ö, Turgut B. YAYGIN BÜYÜK B HÜCRELİ LENFOMA (YBBHL) TANILI OLGULARIN RETROSPEKTİF DEĞERLENDİRMESİ. NKMJ. 2020;8(3):383-90.