Evaluation of transdermal administration of alfa-cyperone (4,11selinadien-3-one) isolated from purple nutsedge (Cyperus rotundus) essential oils as a new drug delivery treatment method for lowering cholesterol

Abstract

The compound alfa-cyperone (4, 11-selinadien-3-one) isolated from purple nutsedge (Cyperus rotundus) essential oil was investigated for cholesterol lowering effect.  In this study, we removed the hair from the back area of the rats, this compound gave us a good result as an alternative drug for lowering serum cholesterol levels via the transdermal route of administration. This compound significantly decreased total serum cholesterol level in rats at p ≤ 0.01.

Keywords

• Transdermal administration, cholesterol-lowering drug, Cyperus rotundus, liver

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