Models of evaluation of antimicrobial activity of essential oils in vapour phase: a promising use in healthcare decontamination

Abstract

Hospital-acquired infections caused by viruses, bacteria and fungi are a constant concern in the health system. In this respect the decontamination of hospital environments is a control measure which decreases the reservoirs of pathogenic microorganisms and their transmission. For that reason new products have been developed such as antimicrobial surfaces that prevent microbial contamination and cleaning vapour systems, in search of a potent disinfection method more friendly to the environment, less toxic, safer and biodegradable. In this way has been considered the use of microbicidal essential oils (EOs) in vapour-phase as an interesting alternative in the development of hospital decontamination devices. Although in vitro antimicrobial activity of EOs have been demonstrated, there are no standardized tests to evaluate these products in vapour-phase, the aim of this review is to present the different evaluation methods that have been used to establish the activity of the vapours of EOs and other disinfectants, with the purpose of provide a rational approach to the research, development and implementation of new biocide agents based on this natural product for cleaning in hospitals and healthcare

Keywords

• Nosocomial infections, decontamination, essential oil, antimicrobial activity, vapour phase

References

1. Al-Yousef, S. (2014). Essential oils: their antimicrobial activity and potential application against pathogens by gaseous contact – a review. Egyptian Academic Journal of Biological Sciences G. Microbiology, 6, 37-54.
2. Allegranzi, B., Nejad, S. B., Combescure, C., Graafmans, W., Attar, H., Donaldson, L. & Pittet, D. (2011). Burden of endemic health-care-associated infection in developing countries: systematic review and meta-analysis. The Lancet, 377, 228-241.
3. Bassolé, I. H. N. & Juliani, H.R. (2012). Essential oils in combination and their antimicrobial properties.
4. Molecules, 17, 3989-4006.
5. Belletti, N., Kamdem, S. S., Patrignani, F., Lanciotti, R., Covelli, A. & Gardini, F. (2007). Antimicrobial activity of aroma compounds against Saccharomyces cerevisiae and improvement of microbiological stability of soft drinks as assessed by logistic regression. Applied and Environmental Microbiology, 73, 5580-5586.
6. Bondi, C. A. (2011). Applying the precautionary principle to consumer household cleaning product development. Journal of Cleaner Production, 19, 429-437.
7. Borkow, G. & Gabbay, J. (2010). Preventing pathogens proliferation and reducing potential sources of nosocomial infections with biocidal textiles in developing countries. The Open Biology Journal, 3, 81-86.
8. Borkow, G. & Monk, A. (2012). Fighting nosocomial infections with biocidal non-intrusive hard and soft surfaces. World Journal of Clinical Infectious Diseases, 2, 77-90.

9. Bowker, R. (2009). Methods of inhibiting growth of microorganisms using disinfectant compositions comprising orange oil mixtures. U.S. Patent No. 7578970 B2, Washington, DC: U.S. Patent and Trademark Office.
10. Bueno, J. (2014). Anti-biofilm drug susceptibility testing methods: looking for new strategies against resistance mechanism. Journal of Microbial & Biochemical Technology S, 3, 2.
11. Carson, C., Hammer, K. & Riley, T. (2006). Melaleuca alternifolia (tea tree) oil: a review of antimicrobial and other medicinal properties. Clinical Microbiology Reviews, 19, 50-62.
12. Chee, H. Y., Kim, H. & Lee, M.H. (2009). In vitro antifungal activity of limonene against Trichophyton rubrum.
13. Mycobiology, 37, 243-246.
14. Chemaly, R. F., Simmons, S., Dale, C., Ghantoji, S. S., Rodriguez, M., Gubb, J.,& Stibich, M. (2014). The role of the healthcare environment in the spread of multidrug-resistant organisms: update on current best practices for containment. Therapeutic Advances in Infectious Disease, 2, 79-90.
15. Coutinho, H. D., Falcão-Silva, V. S., Siqueira-Júnior, J. P. & Costa, J.G. (2010). Use of aromatherapy associated with antibiotic therapy: modulation of the antibiotic activity by the essential oil of Zanthoxylum articulatum using gaseous contact. Journal of Essential Oil Bearing Plants, 13, 670-675.
16. Dancer, S. (2011). Hospital cleaning in the 21st century. European Journal of Clinical Microbiology & Infectious
17. Diseases, 30, 1473-1481.
18. Dancer, S. J. (2008). Importance of the environment in meticillin-resistant Staphylococcus aureus acquisition:
19. the case for hospital cleaning. The Lancet infectious diseases, 8, 101-113.
20. Dancer, S. J. (2014). Controlling Hospital-Acquired Infection: Focus on the Role of the Environment and New
21. Technologies for Decontamination. Clinical Microbiology Reviews, 27, 665-690.
22. De Abreu, P. M., Farias, P. G., Paiva, G. S., Almeida, A. M. & Morais, P.V. (2014). Persistence of microbial communities including Pseudomonas aeruginosa in a hospital environment: a potential health hazard. BMC microbiology, 14, 118.
23. De Oliveira, A. D. L., Rodrigue, F. F. G., Coutinho, H. D. M., da Costa, J. G. M. & de Menezes, I.R.A. (2014). Chemical composition, modulatory bacterial resistance and antimicrobial activity of essential oil the Hyptis
24. martiusii benth by direct and gaseous contact. Jundishapur journal of natural pharmaceutical products, 9, e13521.
25. De Ath, S. (2008). Essential oils based cleaning and disinfecting compositions. U.S. Patent No.7465697 B1, Washington, DC: U.S. Patent and Trademark Office.
26. DeAth, S. S. & Weiss, L. (2012). Essential oils based disinfecting compositions having tuberculocidal and fungicidal efficacies. U.S. Patent No. 8147877 B2, Washington, DC: U.S. Patent and Trademark Office.
27. Donskey, C. J. (2013). Does improving surface cleaning and disinfection reduce health care-associated infections?. American Journal of Infection Control, 41, S12-S19.
28. Doran, A. L., Morden, W., Dunn, K. & Edwards-Jones, V. (2009). Vapour-phase activities of essential oils against antibiotic sensitive and resistant bacteria including MRSA. Letters in Applied Microbiology, 48, 387-392.
29. Epstein, A. K., Pokroy, B., Seminara, A. & Aizenberg, J. (2011). Bacterial biofilm shows persistent resistance to liquid wetting and gas penetration. Proceedings of the National Academy of Sciences, 108, 995-1000.
30. Eterpi, M., McDonnell, G. & Thomas, V. (2011). Decontamination efficacy against Mycoplasma. Letters in
31. Applied Microbiology, 52, 150-155.
32. Faleiro, M. & Miguel, M. (2013). Use of essential oils and their components against multidrug-resistant bacteria. In K. Kon & M. Rai (Eds.), Fighting multidrug resistance with herbal extracts, essential oils and their components (pp. 65-94). San Diego: Academic Press.
33. Fraise, A. P. (2013). Decontamination of the environment and medical equipment in hospitals. In A. P.
34. Fraise, J.Y. Maillard & S. Sattar (Eds.), Russell, Hugo & Ayliffe's: Principles and practice of disinfection, preservation and sterilization, 5th Edition (pp. 445-58). Heidelberg: John Wiley & Sons.
35. Gaunt, L., Higgins, S. & Hughes, J. (2005). Interaction of air ions and bactericidal vapours to control microorganisms. Journal of Applied Microbiology, 99, 1324-1329.
36. Hakkarainen, T. W., Dellinger, E. P., Evans, H. L., Farjah, F., Farrokhi, E., Steele, S. R., Thirlby, R. & Flum, D.R. (2014). Comparative effectiveness of skin antiseptic agents in reducing surgical site infections: a report from the Washington State Surgical Care and Outcomes Assessment Program. Journal of the American College of Surgeons, 218, 336-344.
37. Hall, L., Otter, J. A., Chewins, J. & Wengenack, N.L. (2007). Use of hydrogen peroxide vapour for deactivation of Mycobacterium tuberculosis in a biological safety cabinet and a room. Journal of Clinical Microbiology, 45,
38. -815.
39. Hultman, C., Hill, A. & McDonnell, G. (2007). The physical chemistry of decontamination with gaseous hydrogen peroxide. Pharmaceutical Engineering, 27, 22.
40. Inouye, S., Takizawa, T. & Yamaguchi, H. (2001). Antibacterial activity of essential oils and their major constituents against respiratory tract pathogens by gaseous contact. Journal of Antimicrobial Chemotherapy,
41. , 565-573.
42. Inouye, S., Tsuruoka, T., Watanabe, M., Takeo, K., Akao, M., Nishiyama, Y. & Yamaguchi, H. (2000). Inhibitory effect of essential oils on apical growth of Aspergillus fumigatus by vapour contact. Mycoses, 43, 17-23.
43. Inouye, S., Uchida, K. & Yamaguchi, H. (2001). In-vitro and in-vivo anti-Trichophyton activity of essential oils by vapour contact. Mycoses, 44, 99-107.
44. Inouye, S., Uchida, K., Maruyama, N., Yamaguchi, H. & Abe, S. (2006). A novel method to estimate the contribution of the vapour activity of essential oils in agar diffusion assay. Japanese Journal of Medical Mycology, 47, 91-98.
45. Inouye, S., Uchida, K., Nishiyama, Y., Hasumi, Y., Yamaguchi, H. & Abe, S. (2007). Combined effect of heat, essential oils and salt on the fungicidal activity against Trichophyton mentagrophytes in foot bath. Japanese Journal of Medical Mycology, 48, 27-36.
46. Johnston, M., Lawson, S. & Otter, J. (2005). Evaluation of hydrogen peroxide vapour as a method for the decontamination of surfaces contaminated with Clostridium botulinum spores. Journal of Microbiological Methods, 60, 403-411.
47. Kačer, P., Švrček, J., Syslová, K., Václavík, J., Pavlík, D., Červený, J. & Kuzma, M. (2012). Vapour phase hydrogen peroxide-method for decontamination of surfaces and working areas from organic pollutants. In T. Puzyn (Ed), Organic Pollutants Ten Years after the Stockholm Convention - Environmental and Analytical Update (pp. 400-
48. . Rijeka: InTech publishing.
49. Klapes, N. A. & Vesley, D. (1990). Vapour-phase hydrogen peroxide as a surface decontaminant and sterilant.
50. Applied and Environmental Microbiology, 56, 503-506.
51. Kramer, A., Schwebke, I. & Kampf, G. (2006). How long do nosocomial pathogens persist on inanimate surfaces? A systematic review. BMC infectious diseases, 6, 130.
52. Laird, K. & Phillips, C. (2012). Vapour phase: a potential future use for essential oils as antimicrobials?. Letters in Applied Microbiology, 54, 169-174.
53. Laird, K., Armitage, D. & Phillips, C. (2012). Reduction of surface contamination and biofilms of Enterococcus
54. sp. and Staphylococcus aureus using a citrus-based vapour. Journal of Hospital Infection, 80, 61-66.
55. Li, Y., Fabiano-Tixier, A. & Chemat, F. (2014). Essential oils as antimicrobials. In Y. Ling, A. S. Fabiano-Tixier & F. Chemat (Eds.), Essential oils as reagents in green chemistry (pp. 29-40). New York, NY: Springer.
56. Masaoka, T., Kubota, Y., Namiuchi, S., Takubo, T., Ueda, T., Shibata, H., Nakamura, H., Yoshitake, J., Yamayoshi, T. & Doi, H. (1982). Ozone decontamination of bioclean rooms. Applied and Environmental Microbiology, 43,
57. -513.
58. McCoy, C. P., O`Neil, E. J., Cowley, J. F., Carson, L., De Baróid, Á. T., Gdowski, G. T., Gorman, S. P. & Jones, D.S.
59. (2014). Photodynamic antimicrobial polymers for infection control. PloS one, 9, e108500.
60. Moat, J., Cargill, J., Shone, J. & Upton, M. (2009). Application of a novel decontamination process using gaseous ozone. Canadian Journal of Microbiology, 55, 928-933.
61. Moore, G., Smyth, D., Singleton, J. & Wilson, P. (2010). The use of adenosine triphosphate bioluminescence to assess the efficacy of a modified cleaning program implemented within an intensive care setting. American Journal of Infection Control, 38, 617-622.
62. Nadjib, B. M., Amine, F. M., Abdelkrim, K., Fairouz, S. & Maamar, M. (2014). Liquid and vapour phase antibacterial activity of Eucalyptus globulus essential oil= susceptibility of selected respiratory tract pathogens. American Journal of Infectious Diseases, 10, 105-117.
63. Nostro, A., Marino, A., Blanco, A. R., Cellini, L., Di Giulio, M., Pizzimenti, F., Roccaro, A. S. & Bisignano, G. (2009). In vitro activity of carvacrol against staphylococcal preformed biofilm by liquid and vapour contact. Journal of Medical Microbiology, 58, 791-797.
64. -
65. Passaretti, C. L., Otter, J. A., Reich, N. G., Myers, J., Shepard, J., Ross, T., Carroll, K. C., Lipsett, P. & Perl, T.M. (2013). An evaluation of environmental decontamination with hydrogen peroxide vapour for reducing the risk of patient acquisition of multidrug-resistant organisms. Clinical Infectious Diseases, 56, 27-35.
66. Pines, R. M., Tomasino, S. F., Cottrill, M. P., Hamilton, G. C. & Parker, A.E. (2013). Procedural revision to the AOAC germicidal spray products as disinfectants test method: establishment of minimum and maximum log density values for test microbes on inoculated carriers. Journal of AOAC International, 96, 567-572.
67. Radhouani, H., Silva, N., Poeta, P., Torres, C., Correia, S. & Igrejas, G. (2014). Potential impact of antimicrobial resistance in wildlife, environment and human health. Frontiers in microbiology, 5, 23.
68. Reichling, J., Schnitzler, P., Suschke, U. & Saller, R. (2009). Essential oils of aromatic plants with antibacterial, antifungal, antiviral, and cytotoxic properties-an overview. Forschende Komplementärmedizin/Research in Complementary Medicine, 16, 79-90.
69. Rodrigues, F. F., Costa, J. G. & Henrique, C.D. (2010). Enhancement of the antibiotic activity of gentamicin by volatile compounds of Zanthoxylum articulatum. The Indian Journal of Medical Research, 131, 833-835.
70. Solórzano-Santos, F. & Miranda-Novales, M.G. (2012). Essential oils from aromatic herbs as antimicrobial agents. Current Opinion in Biotechnology, 23, 136-141.
71. Steinberg, J. P., Denham, M. E., Zimring, C., Kasali, A., Hall, K. K. & Jacob, J.T. (2013). The role of the hospital environment in the prevention of healthcare-associated infections by contact transmission. Health Environments Research & Design Journal, 7, 46-73.
72. Tétault, N., Gbaguidi-Haore, H., Bertrand, X., Quentin, R. & Van Der Mee-Marquet, N. (2012). Biocidal activity of metalloacid-coated surfaces against multidrug-resistant microorganisms. Antimicrobial Resistance and Infection Control, 1, 35.
73. Thorn, R., Robinson, G. & Reynolds, D. (2013). Comparative antimicrobial activities of aerosolized sodium hypochlorite, chlorine dioxide, and electrochemically activated solutions evaluated using a novel standardized assay. Antimicrobial Agents and Chemotherapy, 57, 2216-2225.
74. Tuladhar, E., Hazeleger, W. C., Koopmans, M., Zwietering, M. H., Beumer, R. R. & Duizer, E. (2012). Residual viral and bacterial contamination of surfaces after cleaning and disinfection. Applied and Environmental Microbiology, 78, 7769-7775.
75. Tullio, V., Nostro, A., Mandras, N., Dugo, P., Banche, G., Cannatelli, M., Cuffini, A., Alonzo, V. & Carlone, N. (2007). Antifungal activity of essential oils against filamentous fungi determined by broth microdilution and vapour contact methods. Journal of Applied Microbiology, 102, 1544-1550.
76. Turner, D. E., Daugherity, E. K., Altier, C. & Maurer, K.J. (2010). Efficacy and limitations of an ATP-based monitoring system. Journal of the American Association for Laboratory Animal Science: JAALAS, 49, 190.
77. Tyagi, A. K. & Malik, A. (2010). Liquid and vapour-phase antifungal activities of selected essential oils against Candida albicans: microscopic observations and chemical characterization of Cymbopogon citratus. BMC complementary and alternative medicine, 10, 65.
78. Tyagi, A. K. & Malik, A. (2012). Morphostructural damage in food-spoiling bacteria due to the lemon grass oil and its vapour: SEM, TEM, and AFM investigations. Evidence-Based Complementary and Alternative Medicine, ID 692625.
79. -
80. Tyagi, A. K., Bukvicki, D., Gottardi, D., Tabanelli, G., Montanari, C., Malik, A. & Guerzoni, M.E. (2014). Eucalyptus essential oil as a natural food preservative: In vivo and in vitro antiyeast potential. BioMed Research International, ID 969143.
81. Weber, D. J., Anderson, D. & Rutala, W.A. (2013). The role of the surface environment in healthcare-associated infections. Current opinion in infectious diseases, 26, 338-344.
82. Weber, D. J., Rutala, W. A., Miller, M. B., Huslage, K. & Sickbert-Bennett, E. (2010). Role of hospital surfaces in the transmission of emerging health care-associated pathogens: Norovirus, Clostridium difficile, and Acinetobacter species. American Journal of Infection control, 38, S25-S33.
83. Yokoe, D. S., Anderson, D. J., Berenholtz, S. M., Calfee, D. P., Dubberke, E. R., Ellingson, K. D., Gerding, D. N., Haas, J. P., Kaye, K. S. & Klompas, M. (2014). A compendium of strategies to prevent healthcare-associated infections in acute care hospitals: 2014 updates. American Journal of Infection Control, 42, 820-828