Metformin İlişkili Laktik Asidoz: Bir Vaka Sunumu

Year 2025, Volume: 12 Issue: 2, 94 - 99, 31.08.2025

Murat Ugur Ozan , Zekeriya Keskin

https://doi.org/10.56941/odutip.1735247

Abstract

Metformin, tip 2 diyabetes mellitus (DM) tedavisinde yaygın olarak kullanılan etkili ve güvenli bir oral antidiyabetiktir. Ancak nadir görülen fakat mortalitesi yüksek bir komplikasyonu olan metformin ilişkili laktik asidoz (MALA), özellikle predispozan risk faktörlerinin varlığında hayatı tehdit edici bir tabloya yol açabilir. Bu çalışmada, endoskopik işlem hazırlığı sırasında gelişen hipovolemi sonrası akut böbrek hasarı ve ağır laktik asidoz gelişen bir MALA olgusu sunulmaktadır. Tip 2 DM nedeniyle metformin kullanan 56 yaşındaki erkek hasta, endoskopi hazırlığı sonrası gelişen bulantı, kusma ve idrar çıkışında azalma ile başvurdu. Laboratuvar testlerinde ağır metabolic asidoz (pH: 7,05; HCO₃⁻: 8,9 mmol/L; laktat: 21 mmol/L) ve ciddi böbrek fonksiyon bozukluğu (kreatinin: 11,91 mg/dL) saptandı. Klinik ve biyokimyasal bulgularla MALA tanısı konulan hastaya acil hemodiyaliz ve yoğun intravenöz hidrasyon uygulandı. Tedavi sonrası hastanın metabolic parametreleri hızla düzeldi ve diyaliz gereksinimi ortadan kalktı. Poliklinik kontrollerinde renal fonksiyonlarının tamamen normale döndüğü gözlendi. MALA, özellikle renal fonksiyonları etkileyebilecek durumlarda metformin kullanımının devam ettiği olgularda ciddi sonuçlara yolaçabilir. Bu vaka, invaziv işlem hazırlığında metforminin kesilmemesinin potansiyel risklerini ortaya koymakta ve işlem öncesi dönemde metformin tedavisinin durdurulmasının önemine dikkat çekmektedir. MALA şüphesi bulunan olgularda erken tanı ve tedavi, mortaliteyi azaltmada kritik rol oynamaktadır.

Keywords

Metformin , laktik asidoz , MALA , akut böbrek hasarı , hemodiyaliz , endoskopi hazırlığı

Metformin-Associated Lactic Acidosis: A Case Report

Abstract

Metformin is a widely prescribed and effective oral antidiabetic agent used in the treatment of type 2 diabetes mellitus (DM). Although generally well tolerated, metformin-associated lactic acidosis (MALA) is a rare but potentially fatal complication, especially in the presence of predisposing risk factors. Herein, we present a case of MALA that developed after volume depletion related to bowel preparation for endoscopic procedures. A 56-year-old male patient with type 2 diabetes mellitus who was taking metformin presented with nausea, vomiting, and decreased urine output following endoscopy preparation. Laboratory tests revealed severe metabolic acidosis (pH: 7.05; HCO₃⁻: 8.9 mmol/L; lactate: 21 mmol/L) and severe renal dysfunction (creatinine: 11.91 mg/dL). The patient was diagnosed with MALA based on clinical and biochemical findings and underwent emergency hemodialysis and intensive intravenous hydration. After treatment, the patient's metabolic parameters improved rapidly and the need for dialysis disappeared. Outpatient follow-up revealed that renal function had returned to normal.
This case underscores the potential risk of continuing metformin therapy during peri-procedural periods associated with volume depletion. The omission of pre-procedural discontinuation of metformin in our patient likely contributed to the development of life-threatening lactic acidosis. Early diagnosis and timely initiation of renal replacement therapy are critical for reducing mortality in MALA cases.

Keywords

Metformin , lactic acidosis , MALA , acute kidney injury , hemodialysis , endoscopic preparation

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