Fındık Yağının Etanol Kaynaklı Mide Mukozal Hasarına Karşı Gastroprotektif Etkilerinin Değerlendirilmesi

Year 2025, Volume: 12 Issue: 2, 43 - 54, 31.08.2025

Cagri Akalin , Ozlem Ozdemir , Muruvvet Akcay Celik , Onur Olgac Karagulle , Tevfik Noyan

https://doi.org/10.56941/odutip.1737767

Abstract

Bu çalışmada, fındık yağının etanol ile oluşturulan mide mukozal hasarına karşı gastroprotektif etkileri makroskopik ve histopatolojik olarak değerlendirilmiştir. Otuz beş erkek Wistar sıçanı (180–220 g) rastgele beş gruba ayrıldı (n=7): Kontrol (salin), Etanol (%75 etanol, 5 mL/kg), Fındık Yağı-Düşük Doz (HO-L, 2.5 mL/kg fındık yağı + etanol), Fındık Yağı-Yüksek Doz (HO-H, 5 mL/kg fındık yağı + etanol) ve Ranitidin (50 mg/kg + etanol). Tedaviler 7 gün boyunca oral olarak uygulandı, ardından etanol verildi. Ülser alanı, inhibisyon oranı ve histopatolojik skorlar (inflamasyon, ödem, epitel hasarı, hemoraji) değerlendirildi. İstatistiksel analiz tek yönlü ANOVA ve Kruskal-Wallis testleriyle yapıldı. Etanol ciddi mide hasarı oluştururken, HO-L, HO-H ve Ranitidin grupları anlamlı derecede düşük ülser alanları (P < 0.001) ve histopatolojik skorlar (P < 0.005) gösterdi. En yüksek inhibisyon oranı Ranitidin grubunda (%95), ardından HO-H (%78) ve HO-L (%39) ile gözlendi. Fındık yağı, etanol kaynaklı mide hasarına karşı doza bağlı koruyucu etki göstermektedir. Bu etkinin oleik asit ve E vitamini içeriğinden kaynaklandığı düşünülmektedir. Elde edilen bulgular, fındık yağının mide ülserlerinin önlenmesinde doğal bir alternatif olabileceğini göstermektedir.

Keywords

Fındık yağı , mide mukozal hasarı , etanol , gastroproteksiyon , ülser alanı , histopatoloji

Evaluation of the Gastroprotective Effects of Hazelnut Oil Against Ethanol-Induced Gastric Mucosal Injury in Rats

Abstract

This study aimed to investigate the gastroprotective effects of hazelnut oil against ethanol-induced gastric mucosal injury in rats by macroscopic and histopathological evaluations. Thirty-five male Wistar rats (180–220 g) were randomly divided into five groups (n=7): Control (saline), Ethanol (75% ethanol, 5 mL/kg), Hazelnut Oil-Low Dose (HO-L, 2.5 mL/kg hazelnut oil + ethanol), Hazelnut Oil-High Dose (HO-H, 5 mL/kg hazelnut oil + ethanol), and Ranitidine (50 mg/kg + ethanol). Treatments were administered orally for 7 days, followed by ethanol. Ulcer area, inhibition rate, and histopathological scores (inflammation, edema, epithelial damage, hemorrhage) were evaluated. Statistical analysis was performed using one-way ANOVA and Kruskal-Wallis tests. Ethanol induced significant gastric injury, while HO-L, HO-H, and Ranitidine groups showed significantly reduced ulcer areas (P < 0.001) and histopathological scores (P < 0.005). The highest inhibition was observed in the Ranitidine group (95%), followed by HO-H (78%) and HO-L (39%). Hazelnut oil exerts a dose-dependent protective effect against ethanol-induced gastric damage, likely due to its oleic acid and vitamin E content. These findings suggest hazelnut oil may serve as a natural alternative in the prevention of gastric ulcers.

Keywords

Hazelnut oil , gastric mucosal injury , ethanol , gastroprotection , ulcer area , histopathology

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