SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES

Sultan Bütün Şengel; Nilay Tunca; Hatice Deveci; Harun Baş; Vural Bütün

doi:10.31796/ogummf.1204094

TR EN

AKILLI MALZEMELER VE İLERİ BİYOMEDİKAL UYGULAMALARI: HNT VE HNT-POLİMER KOMPOZİTLERİ

Öz

Doğada var olduğu bilinen alüminosilikat kil minerallerine (Al2Si2O5(OH)4·nH2O) halloysit nanotüpler (HNT'ler) olarak adlandırılır. Katmanlı, küresel, yassı ve diğer formlarda bulunan HNT'ler sentetik olarak elde edilebildiği gibi doğal olarak da elde edilebilmektedir. Dış çapı 50 nm ve uzunluğu 500 ile 1000 nm arasında değişen HNT'ler içi boş ve nanotüp şeklinde bir yapıya sahiptir. Brezilya, Türkiye, Yeni Zelanda, Çin, Amerika Birleşik Devletleri, Kore, Japonya ve Fransa'da doğal yatakları bulunan ve cevher saflaştırma yoluyla elde edilebilen düşük maliyetli bir malzemedir. HNT'ler, yüksek yüzey alanları, büyük gözenek hacimleri, reolojik özellikleri, yüksek etkileşimleri ve biyopolimerlerle yüksek bağlanma kapasiteleri sayesinde çok çeşitli alanlarda kullanılırlar. Örneğin, HNT'ler atık su arıtımı ve organik kirleticilerin ve boyaların uzaklaştırılması gibi çevresel uygulamalarda da sıklıkla kullanılan bir malzeme haline gelmiştir. Ayrıca nanoelektronik ve nanokompozitlerin üretiminde, katalitik çalışmalarda, makyaj malzemelerinde alev geciktiricilerde, adli bilimlerde ve biyomedikal alanlarda da kullanılmaktadır. Biyomedikal alanda kullanılan HNT'nin kendine özgü özellikleri çok sayıda uygulama için alternatif bir malzemedir. Bu derlemede, HNT'lerin ilaç taşıyıcı sistemler, immün terapi, anti-enfeksiyon uygulamaları, kanser tedavisi, biyogörüntüleme, biyoalgılama uygulamaları, doku mühendisliği uygulamaları, implantlar ve hijyen-kozmetik malzemelerinde kullanım avantajlarının ortaya konulması amaçlanmaktadır.

Anahtar Kelimeler

Halloysite nanotube , HNTs , clay , HNT-polymer composite , biomedical application

SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES

Abstract

The aluminosilicate clay minerals (Al2Si2O5(OH)4·nH2O) known to exist in nature are called halloysite nanotubes (HNTs). HNTs, which are found in layered, spherical, flat and other forms, can be obtained naturally as well as synthetically. HNTs with an outer diameter of 50 nm and a length ranging from 500 to 1000 nm have a hollow and nanotube-shaped structure. It has natural deposits in Brazil, Turkey, New Zealand, China, the United States, Korea, Japan, and France, and it is a low-cost material that can be obtained through ore purification. Thanks to their high surface area, large pore volume, rheological properties, high interactions, and high binding capacities with biopolymers, HNTs are used in a wide range of areas. For example, HNTs have become a frequently used material in environmental applications such as wastewater treatment and removal of organic contaminants and dyes. It is also used in the production of nanoelectronics and nanocomposites, catalytic studies, flame retardants in make-up materials, forensic sciences and biomedical fields. The specific properties of HNT used in the biomedical field lead to numerous applications. In this review, it is aimed to present the advantages of HNTs for use in drug delivery systems, immune therapy, anti-infection applications, cancer therapy, bioimaging, biosensing applications, tissue engineering applications, implants and hygiene-cosmetics materials.

Keywords

Halloysite nanotube , HNTs , clay , HNT-polymer composite , biomedical application

References

Abdollahi Boraei, S. B., Nourmohammadi, J., Bakhshandeh, B., Dehghan, M. M., Gholami, H., Calle Hernández, D., ... & Ferrari, B. (2021). Enhanced osteogenesis of gelatin-halloysite nanocomposite scaffold mediated by loading strontium ranelate. International Journal of Polymeric Materials and Polymeric Biomaterials, 70(6), 392-402. doi:https://doi.org/10.1080/00914037.2020.1725754
Abhinayaa, R., Jeevitha, G., Mangalaraj, D., Ponpandian, N., & Meena, P. (2019). Toxic influence of pristine and surfactant modified halloysite nanotubes on phytopathogenic bacteria. Applied Clay Science, 174, 57-68. doi: https://doi.org/10.1016/j.clay.2019.03.022
Abhinayaa, R., Jeevitha, G., Mangalaraj, D., Ponpandian, N., Vidhya, K., & Angayarkanni, J. (2018). Cytotoxic consequences of Halloysite nanotube/iron oxide nanocomposite and iron oxide nanoparticles upon interaction with bacterial, non-cancerous and cancerous cells. Colloids and Surfaces B: Biointerfaces, 169, 395-403. doi: https://doi.org/10.1016/j.colsurfb.2018.05.040
Arshad, M. S., Qaiser, M., Mahmood, K., Shoaib, M. H., Ameer, N., Ramzan, N., ... & Abbas, G. (2022). Chitosan/halloysite nanotubes microcomposites: A double header approach for sustained release of ciprofloxacin and its hemostatic effects. International Journal of Biological Macromolecules, 212, 314-323.
doi: https://doi.org/10.1016/j.ijbiomac.2022.05.138
Azmi, S., Razak, S. I. A., Abdul Kadir, M. R., Iqbal, N., Hassan, R., Nayan, N. H. M., ... & Shaharuddin, S. (2017). Reinforcement of poly (vinyl alcohol) hydrogel with halloysite nanotubes as potential biomedical materials. Soft Materials, 15(1), 45-54. doi: https://doi.org/10.1080/1539445X.2016.1242500
Barman, M., Mahmood, S., Augustine, R., Hasan, A., Thomas, S., & Ghosal, K. (2020). Natural halloysite nanotubes/chitosan based bio-nanocomposite for delivering norfloxacin, an anti-microbial agent in sustained release manner. International Journal of Biological Macromolecules, 162, 1849-1861. doi: https://doi.org/10.1016/j.ijbiomac.2020.08.060
Barot, T., Rawtani, D., & Kulkarni, P. (2020a). Physicochemical and biological assessment of silver nanoparticles immobilized Halloysite nanotubes-based resin composite for dental applications. Heliyon, 6(3), e03601 doi: https://doi.org/10.1016/j.heliyon.2020.e03601
Barot, T., Rawtani, D., & Kulkarni, P. (2020b). Development of chlorhexidine loaded halloysite nanotube based experimental resin composite with enhanced physico-mechanical and biological properties for dental applications. Journal of Composites Science, 4(2), 81. doi: https://doi.org/10.3390/jcs4020081
Bertolino, V., Cavallaro, G., Lazzara, G., Milioto, S., & Parisi, F. (2017). Biopolymer-targeted adsorption onto halloysite nanotubes in aqueous media. Langmuir, 33(13), 3317-3323. doi: https://doi.org/10.1021/acs.langmuir.7b00600

Biddeci, G., Spinelli, G., Colomba, P., & Di Blasi, F. (2022). Nanomaterials: A Review about Halloysite Nanotubes, Properties, and Application in the Biological Field. International Journal of Molecular Sciences, 23(19), 11518. doi: https://doi.org/10.3390/ijms231911518
Bonifacio, M. A., Cometa, S., Cochis, A., Gentile, P., Ferreira, A. M., Azzimonti, B., ... & De Giglio, E. (2018). Antibacterial effectiveness meets improved mechanical properties: Manuka honey/gellan gum composite hydrogels for cartilage repair. Carbohydrate Polymers, 198, 462-472. doi: https://doi.org/10.1016/j.carbpol.2018.06.115
Bottino, M. C., Yassen, G. H., Platt, J. A., Labban, N., Windsor, L. J., Spolnik, K. J., & Bressiani, A. H. (2015). A novel three‐dimensional scaffold for regenerative endodontics: materials and biological characterizations. Journal of Tissue Engineering and Regenerative Medicine, 9(11), E116-E123. doi: https://doi.org/10.1002/term.1712
Campana, V., Milano, G. I. U. S. E. P. P. E., Pagano, E., Barba, M., Cicione, C., Salonna, G., ... & Logroscino, G. (2014). Bone substitutes in orthopaedic surgery: from basic science to clinical practice. Journal of Materials Science: Materials in Medicine, 25(10), 2445-2461. doi: https://doi.org/10.1007/s10856-014-5240-2
Cavallaro, G., Milioto, S., Konnova, S., Fakhrullina, G., Akhatova, F., Lazzara, G., ... & Lvov, Y. (2020). Halloysite/keratin nanocomposite for human hair photoprotection coating. ACS Applied Materials & Interfaces, 12(21), 24348-24362. doi: https://doi.org/10.1021/acsami.0c05252
Chen, Q., Zhao, Y., Wu, W., Xu, T., & Fong, H. (2012). Fabrication and evaluation of Bis-GMA/TEGDMA dental resins/composites containing halloysite nanotubes. Dental Materials, 28(10), 1071-1079. doi: https://doi.org/10.1016/j.dental.2007.05.002
Cheng, C., Gao, Y., Song, W., Zhao, Q., Zhang, H., & Zhang, H. (2020). Halloysite nanotube-based H2O2-responsive drug delivery system with a turn on effect on fluorescence for real-time monitoring. Chemical Engineering Journal, 380, 122474. doi: https://doi.org/10.1016/j.cej.2019.122474
Cheng, C., Song, W., Zhao, Q., & Zhang, H. (2020). Halloysite nanotubes in polymer science: Purification, characterization, modification and applications. Nanotechnology Reviews, 9(1), 323-344. doi: https://doi.org/10.1515/ntrev-2020-0024
Cho, K., Yasir, M., Jung, M., Willcox, M. D., Stenzel, M. H., Rajan, G., ... & Prusty, B. G. (2020). Hybrid engineered dental composites by multiscale reinforcements with chitosan-integrated halloysite nanotubes and S-glass fibers. Composites Part B: Engineering, 202, 108448. doi: https://doi.org/10.1016/j.compositesb.2020.108448
Chozhanathmisra, M. A. N. I. C. K. A. M., Govindaraj, D. H. A. R. M. A. N., Karthikeyan, P. A. L. A. N. I. S. A. M. Y., & Rajavel, R. A. N. G. A. P. P. A. N. (2018). Antibacterial efficacy of halloysite nanotube minerals substituted hydroxyapatite composite on titanium alloy using electrodeposition method. Asian Journal of Chemistry, 30(10), 2264-2268. doi: https://doi.org/10.14233/ajchem.2018.21423
Chozhanathmisra, M., Murugesan, L., Murugesan, A., Palanisamy, G., & Rajavel, R. (2022). Enhancement on physical, chemical, and biological properties of HNT-PVA-ALG-HAp biocomposite coating on implant substrate for biomedical application. Ceramics International, 48(12), 16868-16876. doi: https://doi.org/10.1016/j.ceramint.2022.02.241
Chozhanathmisra, M., Ramya, S., Kavitha, L., & Gopi, D. (2016). Development of zinc-halloysite nanotube/minerals substituted hydroxyapatite bilayer coatings on titanium alloy for orthopedic applications. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 511, 357-365. doi: https://doi.org/10.1016/j.colsurfa.2016.10.018
Danyliuk, N., Tomaszewska, J., & Tatarchuk, T. (2020). Halloysite nanotubes and halloysite-based composites for environmental and biomedical applications. Journal of Molecular Liquids, 309, 113077. doi: https://doi.org/10.1016/j.molliq.2020.113077
Das, S., & Baker, A. B. (2016). Biomaterials and nanotherapeutics for enhancing skin wound healing. Frontiers in bioengineering and biotechnology, 4, 82. doi: https://doi.org/10.3389/fbioe.2016.00082
De Kruif, J. K., Ledergerber, G., Garofalo, C., Fasler-Kan, E., & Kuentz, M. (2016). On prilled nanotubes-in-microgel oral systems for protein delivery. European Journal of Pharmaceutics and Biopharmaceutics, 101, 90 102. doi: https://doi.org/10.1016/j.ejpb.2016.01.014
De Silva, R. T., Dissanayake, R. K., Mantilaka, M. P. G., Wijesinghe, W. S. L., Kaleel, S. S., Premachandra, T. N., ... & de Silva, K. N. (2018). Drug-loaded halloysite nanotube-reinforced electrospun alginate-based nanofibrous scaffolds with sustained antimicrobial protection. ACS Applied Materials & Interfaces, 10(40), 33913-33922. doi: https://doi.org/10.1021/acsami.8b11013
Decarli, N. O., Zapp, E., de Souza, B. S., Santana, E. R., Winiarski, J. P., & Vieira, I. C. (2022). Biosensor based on laccase-halloysite nanotube and imidazolium zwitterionic surfactant for dopamine determination. Biochemical Engineering Journal, 186, 108565. doi: https:/doi.org/10.1016/j.bej.2022.108565
Degrazia, F. W., Genari, B., Leitune, V. C. B., Arthur, R. A., Luxan, S. A., Samuel, S. M. W., ... & Sauro, S. (2018). Polymerisation, antibacterial and bioactivity properties of experimental orthodontic adhesives containing triclosan-loaded halloysite nanotubes. Journal of Dentistry, 69, 77-82. doi: https://doi.org/10.1016/j.jdent.2017.11.002
Dramou, P., Fizir, M., Taleb, A., Itatahine, A., Dahiru, N. S., Mehdi, Y. A., ... & He, H. (2018). Folic acid-conjugated chitosan oligosaccharide-magnetic halloysite nanotubes as a delivery system for camptothecin. Carbohydrate Polymers, 197, 117-127. doi: https://doi.org/10.1016/j.carbpol.2018.05.071,
Fakhrullina, G., Khakimova, E., Akhatova, F., Lazzara, G., Parisi, F., & Fakhrullin, R. (2019). Selective antimicrobial effects of curcumin@ halloysite nanoformulation: a Caenorhabditis elegans study. ACS Applied Materials & Interfaces, 11(26), 23050-23064. doi: https://doi.org/10.1021/acsami.9b07499
Feitosa, S., Carreiro, A. F., Martins, V. M., Platt, J. A., & Duarte, S. (2021). Effect of a chlorhexidine-encapsulated nanotube modified pit-and-fissure sealant on oral biofilm. Dental Materials Journal, 40(3), 758-765. doi: https://doi.org/10.4012/dmj.2020-241
Fizir, M., Dramou, P., Dahiru, N. S., Ruya, W., Huang, T., & He, H. (2018). Halloysite nanotubes in analytical sciences and in drug delivery: A review. Microchimica Acta, 185(8), 1-33. doi: https://doi.org/10.1007/s00604-018-2908-1
Gawdzinska, K., Paszkiewicz, S., Piesowicz, E., Bryll, K., Irska, I., Lapis, A., ... & Slaczka, W. (2019). Preparation and characterization of hybrid nanocomposites for dental applications. Applied Sciences, 9(7), 1381. doi: https://doi.org/10.3390/app9071381
Gkouma, E., Gianni, E., Avgoustakis, K., & Papoulis, D. (2021). Applications of halloysite in tissue engineering. Applied Clay Science, 214, 106291. doi: https://doi.org/10.1016/j.clay.2021.106291
Glotov, A., Stavitskaya, A., Novikov, A., Semenov, A., Ivanov, E., Gushchin, P., ... & Lvov, Y. (2019). Halloysite Based Core-Shell Nanosystems: Synthesis and Application. In Nanomaterials from Clay Minerals, 203-256. doi: https://doi.org/10.1016/B978-0-12-0814533-3.00004-1.
Goda, E. S., Gab-Allah, M. A., Singu, B. S., & Yoon, K. R. (2019). Halloysite nanotubes based electrochemical sensors: A review. Microchemical Journal, 147, 1083-1096. doi: https://doi.org/10.1016/j.microc.2019.04.011
Gorbachevskii, M. V., Stavitskaya, A. V., Novikov, A. A., Fakhrullin, R. F., Rozhina, E. V., Naumenko, E. A., & Vinokurov, V. A. (2021). Fluorescent gold nanoclusters stabilized on halloysite nanotubes: In vitro study on cytotoxicity. Applied Clay Science, 207, 106106. doi: https://doi.org/10.1016/j.clay.2021.106106
Gu, B. K., Choi, D. J., Park, S. J., Kim, M. S., Kang, C. M., & Kim, C. H. (2016). 3-dimensional bioprinting for tissue engineering applications. Biomaterials Research, 20(1), 1-8. doi: https://doi.org/10.1186/s40824-016-0058-2
Guimaraes, L., Enyashin, A. N., Seifert, G., & Duarte, H. A. (2010). Structural, electronic, and mechanical properties of single-walled halloysite nanotube models. The Journal of Physical Chemistry C, 114(26), 11358-11363. doi: https://doi.org/10.1021/jp100902e
Guryanov, I., Naumenko, E., Akhatova, F., Lazzara, G., Cavallaro, G., Nigamatzyanova, L., & Fakhrullin, R. (2020). Selective cytotoxic activity of prodigiosin@ halloysite nanoformulation. Frontiers in Bioengineering and Biotechnology, 8, 424. doi: https://doi.org/10.3389/fbioe.2020.00424
Hamedi, S., & Koosha, M. (2020). Designing a pH-responsive drug delivery system for the release of black-carrot anthocyanins loaded in halloysite nanotubes for cancer treatment. Applied Clay Science, 197, 105770. doi: https://doi.org/10.1016/j.clay.2020.105770
Hasan, W. Y., & Ali, M. M. (2018). Evaluation of thermal conductivity and some other properties of heat cured denture soft liner reinforced by halloysite nanotubes. Biomedical and Pharmacology Journal, 11(3), 1491-1500. doi: https://dx.doi.org/10.13005/bpj/1516
Hemmatpour, H., Haddadi-Asl, V., Khanipour, F., Stuart, M. C., Lu, L., Pei, Y., ... & Rudolf, P. (2022). Mussel-inspired grafting pH-responsive brushes onto halloysite nanotubes for controlled release of doxorubicin. European Polymer Journal, 180, 111583. doi: https://doi.org/10.1016/j.eurpolymj.2022.111583
Hendessi, S., Sevinis, E. B., Unal, S., Cebeci, F. C., Menceloglu, Y. Z., & Unal, H. (2016). Antibacterial sustained-release coatings from halloysite nanotubes/waterborne polyurethanes. Progress in Organic Coatings, 101, 253-261. doi: https://doi.org/10.1016/j.porgcoat.2016.09.005
Huang, B., Liu, M., & Zhou, C. (2017). Cellulose–halloysite nanotube composite hydrogels for curcumin delivery. Cellulose, 24(7), 2861-2875. doi: https://doi.org/10.1007/s10570-017-1316-8
Humayun, A., Luo, Y., Elumalai, A., & Mills, D. K. (2022). 3D printed antimicrobial PLA constructs functionalised with zinc-coated halloysite nanotubes-Ag-chitosan oligosaccharide lactate. Materials Technology, 37(1), 28-35. doi: https://doi.org/10.1080/10667857.2020.1806188
Ji, L., Qiao, W., Zhang, Y., Wu, H., Miao, S., Cheng, Z., ... & Zhu, A. (2017). A gelatin composite scaffold strengthened by drug-loaded halloysite nanotubes. Materials Science and Engineering: C, 78, 362-369. doi: https://doi.org/10.1016/j.msec.2017.04.070
Kamal, N., Kochkodan, V., Zekri, A., & Ahzi, S. (2019). Polysulfone membranes embedded with halloysites nanotubes: Preparation and properties. Membranes, 10(1), 2.
doi: https://doi.org/10.3390/membranes10010002
Kazemi-Aghdam, F., Jahed, V., Dehghan-Niri, M., Ganji, F., & Vasheghani-Farahani, E. (2021). Injectable chitosan hydrogel embedding modified halloysite nanotubes for bone tissue engineering. Carbohydrate Polymers, 269, 118311. doi: https://doi.org/10.1016/j.carbpol.2021.118311
Kerman, K., Kobayashi, M., & Tamiya, E. (2003). Recent trends in electrochemical DNA biosensor technology. Measurement Science and Technology, 15(2), R1. doi: https://doi.org/10.1088/0957-0233/15/2/R01
Khan, S., Kumar, V., Roy, P., & Kundu, P. P. (2019). TiO 2 doped chitosan/hydroxyapatite/halloysite nanotube membranes with enhanced mechanical properties and osteoblast-like cell response for application in bone tissue engineering. RSC Advances, 9(68), 39768-39779. doi: https://doi.org/10.1039/c9ra08366a
Khodzhaeva, V., Makeeva, A., Ulyanova, V., Zelenikhin, P., Evtugyn, V., Hardt, M., ... & Ilinskaya, O. (2017). Binase immobilized on halloysite nanotubes exerts enhanced cytotoxicity toward human colon adenocarcinoma cells. Frontiers in Pharmacology, 8, 631. doi: https://doi.org/10.3389/fphar.2017.00
Kokulnathan, T., Chen, T. W., Chen, S. M., Ahmed, F., Hasan, P. M. Z., Bilgrami, A. L., & Kumar, S. (2022). A robust combination of dysprosium vanadate/halloysite nanotubes: the electrochemical system for dimetridazole detection. Materials Today Chemistry, 24, 100890. https://doi.org/10.1016/j.mtchem.2022.100890
Koosha, M., Raoufi, M., & Moravvej, H. (2019). One-pot reactive electrospinning of chitosan/PVA hydrogel nanofibers reinforced by halloysite nanotubes with enhanced fibroblast cell attachment for skin tissue regeneration. Colloids and Surfaces B: Biointerfaces, 179, 270-279. doi: https://doi.org/10.1016/j.colsurfb.2019.03.054
Kumar, A., & Han, S. S. (2021). Enhanced mechanical, biomineralization, and cellular response of nanocomposite hydrogels by bioactive glass and halloysite nanotubes for bone tissue regeneration. Materials Science and Engineering: C, 128, 112236. doi: https://doi.org/10.1016/j.msec.2021.112236
Kurczewska, J., Cegłowski, M., Messyasz, B., & Schroeder, G. (2018). Dendrimer-functionalized halloysite nanotubes for effective drug delivery. Applied Clay Science, 153, 134-143. doi: https://doi.org/10.1016/j.clay.2017.12.019
Kushwaha, S. K. S., Kushwaha, N., Pandey, P., & Fatma, B. (2021). Halloysite nanotubes for nanomedicine: Prospects, challenges and applications. BioNanoScience, 11(1), 200-208. doi: https://doi.org/10.1007/s12668-020-00801-6
Liu, M., Jia, Z., Jia, D., & Zhou, C. (2014). Recent advance in research on halloysite nanotubes-polymer nanocomposite. Progress in Polymer Science, 39(8), 1498-1525. doi:https://doi.org/10.1016/j.progpolymsci.2014.04.004
Liu, J., Zhang, Y., Zeng, Q., Zeng, H., Liu, X., Wu, P., ... & Cao, K. (2019). Delivery of RIPK4 small interfering RNA for bladder cancer therapy using natural halloysite nanotubes. Science Advances, 5(9), eaaw6499. doi: https://doi.org/10.1126%2Fsciadv.aaw6499
Li, H., Zhu, X., Xu, J., Peng, W., Zhong, S., & Wang, Y. (2016). The combination of adsorption by functionalized halloysite nanotubes and encapsulation by polyelectrolyte coatings for sustained drug delivery. RSC Advances, 6(59), 54463-54470. doi: https://doi.org/10.1039/C6RA09599B
Li, Y., Khan, M. S., Tian, L., Liu, L., Hu, L., Fan, D., ... & Wei, Q. (2017). An ultrasensitive electrochemical immunosensor for the detection of prostate-specific antigen based on conductivity nanocomposite with halloysite nanotubes. Analytical and Bioanalytical Chemistry, 409(12), 3245-3251. doi:https://doi.org/10.1007/s00216-017-0266-1
Li, Z., Li, B., Li, X., Lin, Z., Chen, L., Chen, H., ... & Zhang, Y. (2021). Ultrafast in-situ forming halloysite nanotube-doped chitosan/oxidized dextran hydrogels for hemostasis and wound repair. Carbohydrate Polymers, 267, 118155. doi: https://doi.org/10.1016/j.carbpol.2021.118155
Long, M., Zhang, Y., Huang, P., Chang, S., Hu, Y., Yang, Q., ... & Yang, H. (2018). Emerging nanoclay composite for effective hemostasis. Advanced Functional Materials, 28(10), 1704452. doi: https://doi.org/10.1002/adfm.201704452
Long, Z., Wu, Y. P., Gao, H. Y., Li, Y. F., He, R. R., & Liu, M. (2018). Functionalization of halloysite nanotubes via grafting of dendrimer for efficient intracellular delivery of siRNA. Bioconjugate Chemistry, 29(8), 2606-2618. doi: https://doi.org/10.1021/acs.bioconjchem.8b00321
Long, Z., Zhang, J., Shen, Y., Zhou, C., & Liu, M. (2017). Polyethyleneimine grafted short halloysite nanotubes for gene delivery. Materials Science and Engineering: C, 81, 224-235. doi: https://doi.org/10.1016/j.msec.2017.07.035
Lisuzzo, L., Cavallaro, G., Milioto, S., & Lazzara, G. (2021). Halloysite nanotubes filled with salicylic acid and sodium diclofenac: effects of vacuum pumping on loading and release properties. Journal of Nanostructure in Chemistry, 11(4), 663-673.
doi: https://doi.org/10.1007/s40097-021-00391-z
Luo, X., Zhang, J., Wu, Y. P., Yang, X., Kuang, X. P., Li, W. X., ... & Liu, M. (2020). Multifunctional [email protected] 3 O 4@[email protected] Nanoplatform for Effective Chemo-Photothermal Combination Therapy of Breast Cancer with MR Imaging. ACS Biomater. Sci. Eng, 6(6), 3361-3374. doi: https://doi.org/10.1021/acsbiomaterials.9b01709
Mabrouk, M., Beherei, H. H., & Das, D. B. (2020). Recent progress in the fabrication techniques of 3D scaffolds for tissue engineering. Materials Science and Engineering: C, 110, 110716. doi: https://doi.org/10.1016/j.msec.2020.110716
Majumder, S., Viau, C., Brar, A., Xia, J., & George, S. (2022). Silver nanoparticles grafted onto tannic acid-modified halloysite clay eliminated multidrug-resistant Salmonella Typhimurium in a Caenorhabditis elegans model of intestinal infection. Applied Clay Science, 228, 106569. doi: https://doi.org/10.1016/j.clay.2022.106569
Massaro, M., Buscemi, G., Arista, L., Biddeci, G., Cavallaro, G., D’Anna, F., ... & Riela, S. (2018). Multifunctional carrier based on halloysite/laponite hybrid hydrogel for kartogenin delivery. ACS Medicinal Chemistry Letters, 10(4), 419-424. doi: https://doi.org/10.1021/acsmedchemlett.8b00465
Massaro, M., Licandro, E., Cauteruccio, S., Lazzara, G., Liotta, L. F., Notarbartolo, M., ... & Riela, S. (2022). Nanocarrier based on halloysite and fluorescent probe for intracellular delivery of peptide nucleic acids. Journal of Colloid and Interface Science, 620, 221-233. doi: https://doi.org/10.1016/j.jcis.2022.03.151
Mathi, D. B., Gopi, D., & Kavitha, L. (2020, November). Halloysite nanotubes strengthened hydroxyapatite/biopolymer composite coating on titanium for implant applications. In AIP Conference Proceedings (Vol. 2270, No. 1, p. 110025). AIP Publishing LLC. doi: https://doi.org/10.1063/5.0019799
Mo, X., Wu, F., Yu, B., Wang, W., & Cai, X. (2020). Folate-PG modified halloysite nanotube for enhancing tumor targeting and anticancer efficacy. Applied Clay Science, 193, 105664. doi: https://doi.org/10.1016/j.clay.2020.105664
Molaei, A., & Yousefpour, M. (2019). Preparation of Chitosan-based nanocomposites and biomedical investigations in bone tissue engineering. International Journal of Polymeric Materials and Polymeric Biomaterials, 68(12), 701-713. doi: https://doi.org/10.1080/00914037.2018.1493683
Molaei, A., Amadeh, A., Yari, M., & Afshar, M. R. (2016). Structure, apatite inducing ability, and corrosion behavior of chitosan/halloysite nanotube coatings prepared by electrophoretic deposition on titanium substrate. Materials Science and Engineering: C, 59, 740-747. doi: https://doi.org/10.1016/j.msec.2015.10.073
Nekounam, H., Gholizadeh, S., Allahyari, Z., Samadian, H., Nazeri, N., Shokrgozar, M. A., & Faridi-Majidi, R. (2021). Electroconductive Scaffolds for Tissue Regeneration: Current opportunities, pitfalls, and potential solutions. Materials Research Bulletin, 134, 111083. doi: https://doi.org/10.1016/j.materresbull.2020.111083
Ou, Q., Huang, K., Fu, C., Huang, C., Fang, Y., Gu, Z., ... & Wang, Y. (2020). Nanosilver-incorporated halloysite nanotubes/gelatin methacrylate hybrid hydrogel with osteoimmunomodulatory and antibacterial activity for bone regeneration. Chemical Engineering Journal, 382, 123019. doi: https://doi.org/10.1016/j.cej.2019.123019
Panchal, A., Fakhrullina, G., Fakhrullin, R., & Lvov, Y. (2018). Self-assembly of clay nanotubes on hair surface for medical and cosmetic formulations. Nanoscale, 10(38), 18205-18216. doi: https://doi.org/10.1039/C8NR05949G
Paul, A., Augustine, R., Hasan, A., Zahid, A. A., Thomas, S., Agatemor, C., & Ghosal, K. (2022). Halloysite nanotube and chitosan polymer composites: Physicochemical and drug delivery properties. Journal of Drug Delivery Science and Technology, 72, 103380. doi: https://doi.org/10.1016/j.jddst.2022.103380
Persano, F., Gigli, G., & Leporatti, S. (2021). Halloysite-Based Nanosystems for Biomedical Applications. Clays and Clay Minerals, 1-21. doi: https://doi.org/10.1007/s42860-021-00135-8
Prishchenko, D. A., Zenkov, E. V., Mazurenko, V. V., Fakhrullin, R. F., Lvov, Y. M., & Mazurenko, V. G. (2018). Molecular dynamics of the halloysite nanotubes. Physical Chemistry Chemical Physics, 20(8), 5841-5849. https://doi.org/10.1016/j.msec.2020.110716
Sa, L., Kaiwu, L., Shenggui, C., Junzhong, Y., Yongguang, J., Lin, W., & Li, R. (2019). 3D printing dental composite resins with sustaining antibacterial ability. Journal of Materials Science, 54(4), 3309-3318. doi: https://doi.org/10.1007/s10853-018-2801-7
Sahiner, N., & Sengel, S. B. (2017). Various amine functionalized halloysite nanotube as efficient metal free catalysts for H2 generation from sodium borohydride methanolysis. Applied Clay Science, 146, 517-525. doi:https://doi.org/10.1016/j.clay.2017.07.008
Saleh, M., Prajapati, N., Karan, A., Rahman, N., Stavitskaya, A., DeCoster, M., & Lvov, Y. (2021). Halloysite Nanotube Vehicles for Drug Delivery Through a Model Blood–Brain Barrier. Clays and Clay Minerals, 69(5), 603-611. doi: https://doi.org/10.1007/s42860-021-00161-6
Same, S., Kadkhoda, J., Navidi, G., Abedi, F., Aghazadeh, M., Milani, M., ... & Davaran, S. (2022). The fabrication of halloysite nanotube-based multicomponent hydrogel scaffolds for bone healing. Journal of Applied Biomaterials & Functional Materials, 20, 22808000221111875. doi: https://doi.org/10.1177/22808000221111875
Satish, S., Tharmavaram, M., & Rawtani, D. (2019). Halloysite nanotubes as a nature’s boon for biomedical applications. Nanobiomedicine, 6, 1849543519863625. doi: https://doi.org/10.1177%2F1849543519863625
Schmitt, H., Creton, N., Prashantha, K., Soulestin, J., Lacrampe, M. F., & Krawczak, P. (2015). Preparation and characterization of plasticized starch/halloysite porous nanocomposites possibly suitable for biomedical applications. Journal of Applied Polymer Science, 132(4), 41341. doi: https://doi.org/10.1002/app.41341
Sen, L., He, D., Li, S., Chen, R., Yuan, P., Li, S., ... & Gao, Z. (2022). Magnetic Halloysite Nanotube-Based SERS Biosensor Enhanced with Au@ Ag Core–Shell Nanotags for Bisphenol A Determination. Biosensors, 12(6), 387. doi: https://doi.org/10.3390/ bios12060387
Shi, Y. F., Tian, Z., Zhang, Y., Shen, H. B., & Jia, N. Q. (2011). Functionalized halloysite nanotube-based carrier for intracellular delivery of antisense oligonucleotides. Nanoscale Research Letters, 6(1), 1-7. doi: https://doi.org/10.1186%2F1556-276X-6-608
Shu, Z., Zhang, Y., Ouyang, J., & Yang, H. (2017 a). Characterization and synergetic antibacterial properties of ZnO and CeO2 supported by halloysite. Applied Surface Science, 420, 833-838. doi: https://doi.org/10.1016/j.apsusc.2017.05.219
Shu, Z., Zhang, Y., Yang, Q., & Yang, H. (2017 b). Halloysite nanotubes supported Ag and ZnO nanoparticles with synergistically enhanced antibacterial activity. Nanoscale Research Letters, 12(1), 1-7. doi: https://doi.org/10.1186/s11671-017-1859-5
Stavitskaya, A. V., Novikov, A. A., Kotelev, M. S., Kopitsyn, D. S., Rozhina, E. V., Ishmukhametov, I. R., ... & Vinokurov, V. A. (2018). Fluorescence and cytotoxicity of cadmium sulfide quantum dots stabilized on clay nanotubes. Nanomaterials, 8(6), 391. doi: https://doi.org/10.3390/nano8060391
Suner, S. S., Demirci, S., Yetiskin, B., Fakhrullin, R., Naumenko, E., Okay, O., ... & Sahiner, N. (2019). Cryogel composites based on hyaluronic acid and halloysite nanotubes as scaffold for tissue engineering. International journal of biological macromolecules, 130, 627-635. doi: https://doi.org/10.1016/j.ijbiomac.2019.03.025
Tan, C., Zheng, J., Feng, Y., & Liu, M. (2021). Cell Membrane-Coated Halloysite Nanotubes for Target-Specific Nanocarrier for Cancer Phototherapy. Molecules, 26(15), 4483. doi: https://doi.org/10.3390%2Fmolecules26154483,
Tappa, K. K., Jammalamadaka, U. M., & Mills, D. K. (2014, August). Design and evaluation of a nanoenhanced anti-infective calcium phosphate bone cements. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (pp. 3921-3924). IEEE. doi: https://doi.org/10.1109/EMBC.2014.6944481
Torres, E., Dominguez-Candela, I., Castello-Palacios, S., Vallés-Lluch, A., & Fombuena, V. (2020). Development and characterization of polyester and acrylate-based composites with hydroxyapatite and halloysite nanotubes for medical applications. Polymers, 12(8), 1703. doi: https://doi.org/10.3390/polym12081703
Tully, J., Yendluri, R., & Lvov, Y. (2016). Halloysite clay nanotubes for enzyme immobilization. Biomacromolecules, 17(2), 615-621. doi: https://doi.org/10.1021/acs.biomac.5b01542
Venkatesh, C., Fuenmayor, E., Doran, P., Major, I., Lyons, J. G., & Devine, D. M. (2019). Additive manufacturing of PLA/HNT nanocomposites for biomedical applications. Procedia Manufacturing, 38, 17-24. doi: https://doi.org/10.1016/j.promfg.2020.01.003
Wei, P., Jing, W., Yuan, Z., Huang, Y., Guan, B., Zhang, W., ... & Yang, X. (2019). Vancomycin-and strontium-loaded microspheres with multifunctional activities against bacteria, in angiogenesis, and in osteogenesis for enhancing infected bone regeneration. ACS Applied Materials & Interfaces, 11(34), 30596-30609. doi: https://doi.org/10.1021/acsami.9b10219
Wei, W., Abdullayev, E., Hollister, A., Mills, D., & Lvov, Y. M. (2012). Clay nanotube/poly (methyl methacrylate) bone cement composites with sustained antibiotic release. Macromolecular Materials and Engineering, 297(7), 645-653. doi: https://doi.org/10.1002/mame.201100309
Wei, W., Minullina, R., Abdullayev, E., Fakhrullin, R., Mills, D., & Lvov, Y. (2014). Enhanced efficiency of antiseptics with sustained release from clay nanotubes. RSC Advances, 4(1), 488-494. doi: https://doi.org/10.1039/C3RA45011B.
Wu, Y., Yang, Y., Liu, H., Yao, X., Leng, F., Chen, Y., & Tian, W. (2017). Long-term antibacterial protected cotton fabric coating by controlled release of chlorhexidine gluconate from halloysite nanotubes. RSC Advances, 7(31), 18917-18925. doi: https://doi.org/10.1039/C7RA01464C
Xia, D., Jia, Z., Shen, Y., Zheng, Y., Cheng, Y., Xiong, P., ... & Zhou, Y. (2022). pH Stimuli‐Responsive, Rapidly Self‐healable Coatings Enhanced the Corrosion Resistance and Osteogenic Differentiation of Mg‐1Ca Osteoimplant. Small, 2106056. doi: https://doi.org/10.1002/smll.202106056
Yah, W. O., Takahara, A., & Lvov, Y. M. (2012). Selective modification of halloysite lumen with octadecylphosphonic acid: new inorganic tubular micelle. Journal of the American Chemical Society, 134(3), 1853-1859. doi:https://doi.org/10.1021/ja210258y
Yuan, P., Tan, D., & Annabi-Bergaya, F. (2015). Properties and applications of halloysite nanotubes: recent research advances and future prospects. Applied Clay Science, 112, 75-93. doi: https://doi.org/10.1016/j.clay.2015.05.001
Zhang, Y., Chen, Y., Zhang, H., Zhang, B., & Liu, J. (2013). Potent antibacterial activity of a novel silver nanoparticle-halloysite nanotube nanocomposite powder. Journal of Inorganic Biochemistry, 118, 59-64. doi: https://doi.org/10.1016/j.jinorgbio.2012.07.025

Details

Primary Language

English

Subjects

Biomaterials in Biomedical Engineering

Journal Section

Review

Authors

Sultan Bütün Şengel ^*
0000-0001-7036-2224
Türkiye

Nilay Tunca
0000-0003-4314-6096
Türkiye

Hatice Deveci
0000-0002-7386-2213
Türkiye

Harun Baş
0000-0001-6783-4964
Türkiye

Vural Bütün
0000-0003-4542-5080
Türkiye

Early Pub Date

December 22, 2023

Publication Date

December 22, 2023

Submission Date

November 15, 2022

Acceptance Date

August 22, 2023

Published in Issue

Year 1970 Volume: 31 Number: 4

DOI

https://doi.org/10.31796/ogummf.1204094

IZ

https://izlik.org/JA26CB29CE

APA

Bütün Şengel, S., Tunca, N., Deveci, H., Baş, H., & Bütün, V. (2023). SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES. Eskişehir Osmangazi Üniversitesi Mühendislik Ve Mimarlık Fakültesi Dergisi, 31(4), 955-974. https://doi.org/10.31796/ogummf.1204094

AMA

1.Bütün Şengel S, Tunca N, Deveci H, Baş H, Bütün V. SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi. 2023;31(4):955-974. doi:10.31796/ogummf.1204094

Chicago

Bütün Şengel, Sultan, Nilay Tunca, Hatice Deveci, Harun Baş, and Vural Bütün. 2023. “SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES”. Eskişehir Osmangazi Üniversitesi Mühendislik Ve Mimarlık Fakültesi Dergisi 31 (4): 955-74. https://doi.org/10.31796/ogummf.1204094.

EndNote

Bütün Şengel S, Tunca N, Deveci H, Baş H, Bütün V (December 1, 2023) SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi 31 4 955–974.

IEEE

[1]S. Bütün Şengel, N. Tunca, H. Deveci, H. Baş, and V. Bütün, “SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES”, Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi, vol. 31, no. 4, pp. 955–974, Dec. 2023, doi: 10.31796/ogummf.1204094.

ISNAD

Bütün Şengel, Sultan - Tunca, Nilay - Deveci, Hatice - Baş, Harun - Bütün, Vural. “SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES”. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi 31/4 (December 1, 2023): 955-974. https://doi.org/10.31796/ogummf.1204094.

JAMA

1.Bütün Şengel S, Tunca N, Deveci H, Baş H, Bütün V. SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi. 2023;31:955–974.

MLA

Bütün Şengel, Sultan, et al. “SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES”. Eskişehir Osmangazi Üniversitesi Mühendislik Ve Mimarlık Fakültesi Dergisi, vol. 31, no. 4, Dec. 2023, pp. 955-74, doi:10.31796/ogummf.1204094.

Vancouver

1.Sultan Bütün Şengel, Nilay Tunca, Hatice Deveci, Harun Baş, Vural Bütün. SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi. 2023 Dec. 1;31(4):955-74. doi:10.31796/ogummf.1204094

Cited By

Fabrication and investigation of halloysite-incorporated decellularized bovine tendon extracellular matrix as a scaffold for bone tissue engineering

Materials Today Communications

https://doi.org/10.1016/j.mtcomm.2025.113332

Functional halloysite nanotubes: Emerging roles in biomedicine, environmental remediation, and smart materials

Next Chemical Engineering

https://doi.org/10.1016/j.nxcen.2025.100014

State-of-the-art nanocomposites: Tailoring material properties for next-generation applications

Next Research

https://doi.org/10.1016/j.nexres.2025.100865