SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES

Sultan Bütün Şengel; Nilay Tunca; Hatice Deveci; Harun Baş; Vural Bütün

doi:10.31796/ogummf.1204094

TR EN

AKILLI MALZEMELER VE İLERİ BİYOMEDİKAL UYGULAMALARI: HNT VE HNT-POLİMER KOMPOZİTLERİ

Abstract

Doğada var olduğu bilinen alüminosilikat kil minerallerine (Al2Si2O5(OH)4·nH2O) halloysit nanotüpler (HNT'ler) olarak adlandırılır. Katmanlı, küresel, yassı ve diğer formlarda bulunan HNT'ler sentetik olarak elde edilebildiği gibi doğal olarak da elde edilebilmektedir. Dış çapı 50 nm ve uzunluğu 500 ile 1000 nm arasında değişen HNT'ler içi boş ve nanotüp şeklinde bir yapıya sahiptir. Brezilya, Türkiye, Yeni Zelanda, Çin, Amerika Birleşik Devletleri, Kore, Japonya ve Fransa'da doğal yatakları bulunan ve cevher saflaştırma yoluyla elde edilebilen düşük maliyetli bir malzemedir. HNT'ler, yüksek yüzey alanları, büyük gözenek hacimleri, reolojik özellikleri, yüksek etkileşimleri ve biyopolimerlerle yüksek bağlanma kapasiteleri sayesinde çok çeşitli alanlarda kullanılırlar. Örneğin, HNT'ler atık su arıtımı ve organik kirleticilerin ve boyaların uzaklaştırılması gibi çevresel uygulamalarda da sıklıkla kullanılan bir malzeme haline gelmiştir. Ayrıca nanoelektronik ve nanokompozitlerin üretiminde, katalitik çalışmalarda, makyaj malzemelerinde alev geciktiricilerde, adli bilimlerde ve biyomedikal alanlarda da kullanılmaktadır. Biyomedikal alanda kullanılan HNT'nin kendine özgü özellikleri çok sayıda uygulama için alternatif bir malzemedir. Bu derlemede, HNT'lerin ilaç taşıyıcı sistemler, immün terapi, anti-enfeksiyon uygulamaları, kanser tedavisi, biyogörüntüleme, biyoalgılama uygulamaları, doku mühendisliği uygulamaları, implantlar ve hijyen-kozmetik malzemelerinde kullanım avantajlarının ortaya konulması amaçlanmaktadır.

Keywords

Halloysite nanotube, HNTs, clay, HNT-polymer composite, biomedical application

SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES

Abstract

The aluminosilicate clay minerals (Al2Si2O5(OH)4·nH2O) known to exist in nature are called halloysite nanotubes (HNTs). HNTs, which are found in layered, spherical, flat and other forms, can be obtained naturally as well as synthetically. HNTs with an outer diameter of 50 nm and a length ranging from 500 to 1000 nm have a hollow and nanotube-shaped structure. It has natural deposits in Brazil, Turkey, New Zealand, China, the United States, Korea, Japan, and France, and it is a low-cost material that can be obtained through ore purification. Thanks to their high surface area, large pore volume, rheological properties, high interactions, and high binding capacities with biopolymers, HNTs are used in a wide range of areas. For example, HNTs have become a frequently used material in environmental applications such as wastewater treatment and removal of organic contaminants and dyes. It is also used in the production of nanoelectronics and nanocomposites, catalytic studies, flame retardants in make-up materials, forensic sciences and biomedical fields. The specific properties of HNT used in the biomedical field lead to numerous applications. In this review, it is aimed to present the advantages of HNTs for use in drug delivery systems, immune therapy, anti-infection applications, cancer therapy, bioimaging, biosensing applications, tissue engineering applications, implants and hygiene-cosmetics materials.

Keywords

Halloysite nanotube, HNTs, clay, HNT-polymer composite, biomedical application

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Details

Primary Language

English

Subjects

Biomaterials in Biomedical Engineering

Journal Section

Review

Authors

Sultan Bütün Şengel ^*
0000-0001-7036-2224
Türkiye

Nilay Tunca
0000-0003-4314-6096
Türkiye

Hatice Deveci
0000-0002-7386-2213
Türkiye

Harun Baş
0000-0001-6783-4964
Türkiye

Vural Bütün
0000-0003-4542-5080
Türkiye

Early Pub Date

December 22, 2023

Publication Date

December 22, 2023

Submission Date

November 15, 2022

Acceptance Date

August 22, 2023

Published in Issue

Year 2023 Volume: 31 Number: 4

DOI

https://doi.org/10.31796/ogummf.1204094

IZ

https://izlik.org/JA26CB29CE

APA

Bütün Şengel, S., Tunca, N., Deveci, H., Baş, H., & Bütün, V. (2023). SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES. Eskişehir Osmangazi Üniversitesi Mühendislik Ve Mimarlık Fakültesi Dergisi, 31(4), 955-974. https://doi.org/10.31796/ogummf.1204094

AMA

1.Bütün Şengel S, Tunca N, Deveci H, Baş H, Bütün V. SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi. 2023;31(4):955-974. doi:10.31796/ogummf.1204094

Chicago

Bütün Şengel, Sultan, Nilay Tunca, Hatice Deveci, Harun Baş, and Vural Bütün. 2023. “SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES”. Eskişehir Osmangazi Üniversitesi Mühendislik Ve Mimarlık Fakültesi Dergisi 31 (4): 955-74. https://doi.org/10.31796/ogummf.1204094.

EndNote

Bütün Şengel S, Tunca N, Deveci H, Baş H, Bütün V (December 1, 2023) SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi 31 4 955–974.

IEEE

[1]S. Bütün Şengel, N. Tunca, H. Deveci, H. Baş, and V. Bütün, “SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES”, Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi, vol. 31, no. 4, pp. 955–974, Dec. 2023, doi: 10.31796/ogummf.1204094.

ISNAD

Bütün Şengel, Sultan - Tunca, Nilay - Deveci, Hatice - Baş, Harun - Bütün, Vural. “SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES”. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi 31/4 (December 1, 2023): 955-974. https://doi.org/10.31796/ogummf.1204094.

JAMA

1.Bütün Şengel S, Tunca N, Deveci H, Baş H, Bütün V. SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi. 2023;31:955–974.

MLA

Bütün Şengel, Sultan, et al. “SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES”. Eskişehir Osmangazi Üniversitesi Mühendislik Ve Mimarlık Fakültesi Dergisi, vol. 31, no. 4, Dec. 2023, pp. 955-74, doi:10.31796/ogummf.1204094.

Vancouver

1.Sultan Bütün Şengel, Nilay Tunca, Hatice Deveci, Harun Baş, Vural Bütün. SMART MATERIALS AND THEIR ADVANCED BIOMEDICAL APPLICATIONS: HNT AND HNT-POLYMER COMPOSITES. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi. 2023 Dec. 1;31(4):955-74. doi:10.31796/ogummf.1204094

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