İlaç Taşımaya Yönelik Yeni Mezogözenekli Fe3O4 Nanotüplerin Sentezi ve Karakterizasyonu

Year 2023, Volume: 6 Issue: 2, 1353 - 1368, 05.07.2023

Fatma Ulusal , Nalan Özdemir

Abstract

Manyetik nanopartiküller birçok kullanım alanına sahip olup manyetik olarak saflaştırılabilirlik, geniş yüzey alanı, manyetik hedefleme, yüzey modifikasyonunda kolaylık gibi avantajları sayesinde son yıllarda ilgi çeken malzemelerden biri olmuştur. Gözenekli malzemeler ise, daha fazla açığa çıkan katalitik bölgelere ve geliştirilmiş yüzey işlevselliğine sahip bir malzemeye eldesine imkan sağlar. Ayrıca mezogözenekli Fe3O4 nanotüpleri sahip olduğu eşsiz yapısı sayesinde, bağlanacak ilaç hem destek malzemesinin dış yüzeyine hem de mezogözeneklerine girerek paketlenmiş yapıya benzer bir şekilde bağlanacaktır. Bu sayede hem ilacın yarılanma ömrünü uzatacak hem de parçalanma ürünlerinin hızlı serbestleşmesini engelleyeceğinden ilacın kontrollü bir şekilde taşınabilmesi için ideal bir sistem oluşturacaktır. Bu makalede ilaç hedeflemede kullanılmak üzere mezogözenekli Fe3O4 nanotüp sentezi yapılmıştır. Bu amaçla öncelikle mezogözenekli SiO2 üretimi yapılarak Fe3O4 üretiminde şablon olarak kullanılmıştır. Üretilen mezogözenekli SiO2 yüzeyine, [Fe(NH2CONH2)6](NO3)3 kompleksi kullanılarak Fe3O4 indirgenmiş ve ardından yapıdaki SiO2 liç edilerek mezogözenekli Fe3O4 nanotüp hazırlanmıştır. Hazırlanan malzemeler FESEM, FT-IR, BET, XRD ve TG yöntemleri ile analiz edilmiştir.

Keywords

mezogözenekli SiO2, Mezogözenekli Fe3O4 nanotüp, üre, sol-jel yöntemi

Supporting Institution

TÜBİTAK-BİDEB-2218

Project Number

118C475

Thanks

Bu çalışma TÜBİTAK-BİDEB-2218 Yurt İçi Doktora Sonrası Araştırma Burs Programı kapsamında 118C475 numaralı proje ile desteklenmiştir. Desteklerinden dolayı TÜBİTAK’a sonsuz teşekkür ederiz.

Synthesis and Characterization of Novel Mesoporous Fe3O4 Nanotubes for Drug Delivery

Abstract

Magnetic nanoparticles have many uses and have become one of the materials that have attracted attention in recent years, thanks to their advantages such as magnetic purification, large surface area, magnetic targeting, and ease of surface modification. Porous materials, on the other hand, allow for a material with more exposed catalytic sites and improved surface functionality. In addition, thanks to the unique structure of mesoporous Fe3O4 nanotubes, the drug to be bound will enter both the outer surface of the support material and the mesopores and bind in a similar way to the packaged structure. In this way, it will create an ideal system for the controlled transport of the drug, as it will both prolong the half-life of the drug and prevent the rapid release of degradation products. In this article, mesoporous Fe3O4 nanotubes were synthesized to be used in drug targeting. For this purpose, firstly mesoporous SiO2 was produced and used as a template in Fe3O4 production. Fe3O4 was reduced to the produced mesoporous SiO2 surface by using [Fe(NH2CONH2)6](NO3)3 complex and then mesoporous Fe3O4 nanotube was prepared by leaching SiO2 in the structure. The prepared materials were analyzed by FESEM, FT-IR, BET, XRD and TG methods.

Keywords

Mesoporous SiO2, Mesoporous Fe3O4 nanotubes, Sol-gel method, urea

Project Number

118C475

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