Analysis of patients admitted to the emergency service for warfarin complication and determination of their levels of knowledge and requirements of knowledge about warfarin use

Year 2017, Volume: 34 Issue: 4, 247 - 250, 10.10.2019

Ali Duman , Ayhan Akoz Bekir Dagli Mucahit Kapci Mucahit Avcil Ferdi Ozdemir

Abstract

Warfarin is a cumarol derivative anticoagulant. It shows its effect by antagoniz-
ing the effects of Vitamin K. Warfarin is metabolized in the liver. International
normalized ratio has been developed in the monitorization of warfarin. It is a
drug which has a limited therapeutic index. The difference in sensitivity for
therapy dose among individuals depends on the genetic polymorphism of the
two enzymes in the liver. The objective of our study was to assess the informa-
tion about the demographic characteristics, complications, treatments and the
related factors of the patients who were admitted to our emergency service for
high INR in routine controls and of the cases who had bleeding due to warfarin
overdose. Of the 18-year-old and older patients who were admitted to our emer-
gency service with a complaint related to warfarin use and who had been using
warfarin on admission and patients who had an INR value of over 3.0 although
the patient had no complaints, those who accepted to participate in the study
were included in the study. The results of the demographic characteristics, com-
plications and treatments of the 59 patients included in the study were in paral-
lel with the literature. The rate of patients’ being informed was found as 61%.
Although difference was found when the demographic data of the informed and
non-informed groups and their answers to the questions asked for warfarin in-
formation level were compared, no statistically significant difference was found
(p>0.005). This brings to mind that the information given to patients at the time
of first prescription is not sufficient and it does not turn into a regular training. 

Keywords

Drug information, Emergency Service, Warfarin, Warfarin complication

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