Research Article
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Year 2021, Volume: 38 Issue: 3, 308 - 311, 01.05.2021

Abstract

References

  • Abbott, R., Chandra, M., Chandra, R., 2010. Total Platelet Count, Adhesive Platelet Count, Platelet Adhesiveness in Normal Menstrual Cycle and Functional Uterine Bleeding: A Comparative Study. Asia-Oceania Journal of Obstetrics and Gynaecology 9, 265–269. https://doi.org/10.1111/j.1447-0756.1983.tb00631.x
  • Alzahrani, F., Hassan, F., 2019. Modulation of Platelet Functions Assessment during Menstruation and Ovulatory Phases. Journal of medicine and life 12, 296–300. https://doi.org/10.25122/jml-2019-0005
  • Bain, B.J., England, J.M., 1975. Variations in Leucocyte Count During Menstrual Cycle. British Medical Journal 2, 473–475. https://doi.org/10.1136/bmj.2.5969.473
  • Bouman, A., Jan Heineman, M., Faas, M.M., 2005. Sex hormones and the immune response in humans. Human Reproduction Update 11, 411-423. https://doi.org/10.1093/humupd/dmi008
  • Bouman, A., Moes, H., Heineman, M.J., De Leij, L.F.M.H., Faas, M.M., 2001. The immune response during the luteal phase of the ovarian cycle: Increasing sensitivity of human monocytes to endotoxin. Fertility and Sterility 76, 555–559. https://doi.org/10.1016/S0015-0282(01)01971-9
  • Dapper, D.V.B., Didia, B.C., 2002. Haemorheological changes during the menstrual cycle. East African Medical Journal 79, 181–183. https://doi.org/10.4314/eamj.v79i4.8874
  • Drici, M.D., Burklow, T.R., Haridasse, V., Glazer, R.I., Woosley, R.L., 1996. Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart. Circulation 94, 1471–1474. https://doi.org/10.1161/01.cir.94.6.1471
  • Dullo, P., Vedi, N., 2008. Changes in serum calcium, magnesium and inorganic phosphorus levels during different phases of the menstrual cycle. Journal of Human Reproductive Sciences 1, 77. https://doi.org/10.4103/0974-1208.44115
  • Faas, M., Bouman, A., Moesa, H., Heineman, M.J., De Leij, L., Schuiling, G., 2000. The immune response during the luteal phase of the ovarian cycle: A Th2-type response? Fertility and Sterility 74, 1008–1013. https://doi.org/10.1016/S0015-0282(00)01553-3
  • Harewood, W.J., Gillin, A., Hennessy, A., Armitstead, J., Horvath, J.S., Tiller, D.J., 2000. The effects of the menstrual cycle, pregnancy and early lactation on haematology and plasma biochemistry in the baboon (Papio hamadryas). Journal of Medical Primatology 29, 415–420. https://doi.org/10.1111/j.1600-0684.2000.290606.x
  • Kumar Chawla, V., Choudhary, R., Kumar Binawara, B., Choudhary, S., 2010. HAEMATOLOGICAL AND ELECTROCARDIOGRAPHIC VARIATIONS DURING MENSTRUAL CYCLE, Pak J Physiol 6, 18-21. http://www.pps.org.pk/PJP/6-1/Ranjee.pdf
  • Makinoda, S., Mikuni, M., Sogame, M., Kobamatsu, Y., Furuta, I., Yamada, H., Yamamoto, R., Fujimoto, S., 1996. Erythropoietin, granulocyte-colony stimulating factor, interleukin-1β and interleukin-6 during the normal menstrual cycle. International Journal of Gynecology & Obstetrics 55, 265–271. https://doi.org/10.1016/S0020-7292(96)02769-5
  • Malipatil, B.S., Patil, S., 2013. HEMATOLOGICAL MODULATION IN DIFFERENT PHASES OF MENSTRUAL CYCLE. Int Jour of Biomed Res 4, 88. https://doi.org/10.7439/ijbr.v4i2.932
  • Molloy, E.J., O’Neill, A.J., Grantham, J.J., Sheridan-Pereira, M., Fitzpatrick, J.M., Webb, D.W., Watson, R.W.G., 2003. Sex-specific alterations in neutrophil apoptosis: The role of estradiol and progesterone. Blood 102, 2653–2659. https://doi.org/10.1182/blood-2003-02-0649
  • Northern, A.L.D., Rutter, S.M., Peterson, C.M., 1994. Cyclic changes in the concentrations of peripheral blood immune cells during the normal menstrual cycle. Proceedings of the Society for Experimental Biology and Medicine 207, 81–88. https://doi.org/10.3181/00379727-207-43795
  • Pathak, C.L., Kahali, B.S., 1957. Cyclic variations in the eosinophil count during the phases of the menstrual cycle. The Journal of Clinical Endocrinology & Metabolism 17, 862–869. https://doi.org/10.1210/jcem-17-7-862
  • Pehlivanoǧlu, B., Balkanci, Z.D., Ridvanaǧaoǧlu, A.Y., Durmazlar, N., Öztürk, G., Erbaş, D., Okur, H., 2001. Impact of stress, gender and menstrual cycle on immune system: Possible role of nitric oxide. Archives of Physiology and Biochemistry 109, 383–387. https://doi.org/10.1076/apab.109.4.383.4234
  • Reeves, J.T., Zamudio, S., Dahms, T.E., Asmus, I., Braun, B., Butterfield, G.E., McCullough, R.G., Muza, S.R., Rock, P.B., Moore, L.G., 2001. Erythropoiesis in women during 11 days at 4,300 m is not affected by menstrual cycle phase. Journal of Applied Physiology 91, 2579–2586. https://doi.org/10.1152/jappl.2001.91.6.2579
  • Shilpa, N., Itagi, V., Rani, R., 2018. A Study of Hemoglobin Concentration in Different Phases of Menstrual Cycle. International Journal of Physiology 6, 90. https://doi.org/10.5958/2320-608x.2018.00059.8
  • Thiyagarajan, D.K., Jeanmonod, R., 2019. Physiology, Menstrual Cycle, StatPearls. StatPearls Publishing.
  • Thongngarm, T., Jenkins, J.K., Ndebele, K., McMurray, R.W., 2003. Estrogen and progesterone modulate monocyte cell cycle progression and apoptosis. American Journal of Reproductive Immunology 49, 129–138. https://doi.org/10.1034/j.1600-0897.2003.00015.x
  • Tikare, S.N., Das, K.K., Dhundasi, S.A., 2008. Blood leukocyte profile in different phases of menstrual cycle. Indian J Physiol Pharmacol 52, 201–204.
  • Tindall VR, 1987. Jeffcoate’s principles of Gynecology, 5th ed. Butterworth-Heinemann & Co Ltd, London.
  • Treloar, A.E., Boynton, R.E., Behn, B.G., Brown, B.W., 1970. Variation of the human menstrual cycle through reproductive life. International Journal of Fertility 12, 77–126.
  • Usha Rani M D, Y.S., Manjunath N B, P.D., D, Knn.M., 2014. Comparative Study of Hematological and Biochemical Parameters during Different Phases of Menstrual Cycle in Young Healthy Women Aged 18-22 Years, IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN 9, 09-11. http://www.iosrjournals.org/iosr-jdms/papers/Vol9-issue2/B0920911.pdf
  • Van Den Heuvel, M.J., Horrocks, J., Bashar, S., Taylor, S., Burke, S., Hatta, K., Lewis, J.E., Croy, B.A., 2005. Menstrual cycle hormones induce changes in functional interactions between lymphocytes and decidual vascular endothelial cells. Journal of Clinical Endocrinology and Metabolism 90, 2835–2842. https://doi.org/10.1210/jc.2004-1742.

A Study on Influence of Different Phases of Menstrual Cycle on Hematological Parameters

Year 2021, Volume: 38 Issue: 3, 308 - 311, 01.05.2021

Abstract

Objective: Menstruation is the most common phenomenon observed in fertile women. Menstrual cycle (MC) is of 3 phases: proliferative phase, secretory phase and menstruation phase. It is controlled by endocrine system. Natural fluctuations in sex steroid hormones during MC causes changes in hematological parameters. The aim of the present study to assess the impact of different phases of MC on hematological parameters.
Methods: The study was conducted in KIMS, Hubli, from 01st March 2011 to 31st March 2012. Women aged between 20-30 years with regular menstrual cycle of 27-30 days were included in the study. During each visit, the subjects’ blood was collected and analyzed using KX-21 SYSMEX for various hematological parameters.
Results: A total of 50 healthy young women were included in the study. On statistical comparing of hematological parameters, hematocrit, hemoglobin, neutrophil count and eosinophil count showed a significant difference while no statistically significant difference was observed in RBC, leucocyte count, lymphocyte count, monocyte count, erythrocyte sedimentation rate (ESR) and platelet count between different phases of MC.
Conclusion: To conclude, the hematological parameters during the MC are highly dependent on the phasic changes in the immune response mechanism and sex steroid hormones.

References

  • Abbott, R., Chandra, M., Chandra, R., 2010. Total Platelet Count, Adhesive Platelet Count, Platelet Adhesiveness in Normal Menstrual Cycle and Functional Uterine Bleeding: A Comparative Study. Asia-Oceania Journal of Obstetrics and Gynaecology 9, 265–269. https://doi.org/10.1111/j.1447-0756.1983.tb00631.x
  • Alzahrani, F., Hassan, F., 2019. Modulation of Platelet Functions Assessment during Menstruation and Ovulatory Phases. Journal of medicine and life 12, 296–300. https://doi.org/10.25122/jml-2019-0005
  • Bain, B.J., England, J.M., 1975. Variations in Leucocyte Count During Menstrual Cycle. British Medical Journal 2, 473–475. https://doi.org/10.1136/bmj.2.5969.473
  • Bouman, A., Jan Heineman, M., Faas, M.M., 2005. Sex hormones and the immune response in humans. Human Reproduction Update 11, 411-423. https://doi.org/10.1093/humupd/dmi008
  • Bouman, A., Moes, H., Heineman, M.J., De Leij, L.F.M.H., Faas, M.M., 2001. The immune response during the luteal phase of the ovarian cycle: Increasing sensitivity of human monocytes to endotoxin. Fertility and Sterility 76, 555–559. https://doi.org/10.1016/S0015-0282(01)01971-9
  • Dapper, D.V.B., Didia, B.C., 2002. Haemorheological changes during the menstrual cycle. East African Medical Journal 79, 181–183. https://doi.org/10.4314/eamj.v79i4.8874
  • Drici, M.D., Burklow, T.R., Haridasse, V., Glazer, R.I., Woosley, R.L., 1996. Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart. Circulation 94, 1471–1474. https://doi.org/10.1161/01.cir.94.6.1471
  • Dullo, P., Vedi, N., 2008. Changes in serum calcium, magnesium and inorganic phosphorus levels during different phases of the menstrual cycle. Journal of Human Reproductive Sciences 1, 77. https://doi.org/10.4103/0974-1208.44115
  • Faas, M., Bouman, A., Moesa, H., Heineman, M.J., De Leij, L., Schuiling, G., 2000. The immune response during the luteal phase of the ovarian cycle: A Th2-type response? Fertility and Sterility 74, 1008–1013. https://doi.org/10.1016/S0015-0282(00)01553-3
  • Harewood, W.J., Gillin, A., Hennessy, A., Armitstead, J., Horvath, J.S., Tiller, D.J., 2000. The effects of the menstrual cycle, pregnancy and early lactation on haematology and plasma biochemistry in the baboon (Papio hamadryas). Journal of Medical Primatology 29, 415–420. https://doi.org/10.1111/j.1600-0684.2000.290606.x
  • Kumar Chawla, V., Choudhary, R., Kumar Binawara, B., Choudhary, S., 2010. HAEMATOLOGICAL AND ELECTROCARDIOGRAPHIC VARIATIONS DURING MENSTRUAL CYCLE, Pak J Physiol 6, 18-21. http://www.pps.org.pk/PJP/6-1/Ranjee.pdf
  • Makinoda, S., Mikuni, M., Sogame, M., Kobamatsu, Y., Furuta, I., Yamada, H., Yamamoto, R., Fujimoto, S., 1996. Erythropoietin, granulocyte-colony stimulating factor, interleukin-1β and interleukin-6 during the normal menstrual cycle. International Journal of Gynecology & Obstetrics 55, 265–271. https://doi.org/10.1016/S0020-7292(96)02769-5
  • Malipatil, B.S., Patil, S., 2013. HEMATOLOGICAL MODULATION IN DIFFERENT PHASES OF MENSTRUAL CYCLE. Int Jour of Biomed Res 4, 88. https://doi.org/10.7439/ijbr.v4i2.932
  • Molloy, E.J., O’Neill, A.J., Grantham, J.J., Sheridan-Pereira, M., Fitzpatrick, J.M., Webb, D.W., Watson, R.W.G., 2003. Sex-specific alterations in neutrophil apoptosis: The role of estradiol and progesterone. Blood 102, 2653–2659. https://doi.org/10.1182/blood-2003-02-0649
  • Northern, A.L.D., Rutter, S.M., Peterson, C.M., 1994. Cyclic changes in the concentrations of peripheral blood immune cells during the normal menstrual cycle. Proceedings of the Society for Experimental Biology and Medicine 207, 81–88. https://doi.org/10.3181/00379727-207-43795
  • Pathak, C.L., Kahali, B.S., 1957. Cyclic variations in the eosinophil count during the phases of the menstrual cycle. The Journal of Clinical Endocrinology & Metabolism 17, 862–869. https://doi.org/10.1210/jcem-17-7-862
  • Pehlivanoǧlu, B., Balkanci, Z.D., Ridvanaǧaoǧlu, A.Y., Durmazlar, N., Öztürk, G., Erbaş, D., Okur, H., 2001. Impact of stress, gender and menstrual cycle on immune system: Possible role of nitric oxide. Archives of Physiology and Biochemistry 109, 383–387. https://doi.org/10.1076/apab.109.4.383.4234
  • Reeves, J.T., Zamudio, S., Dahms, T.E., Asmus, I., Braun, B., Butterfield, G.E., McCullough, R.G., Muza, S.R., Rock, P.B., Moore, L.G., 2001. Erythropoiesis in women during 11 days at 4,300 m is not affected by menstrual cycle phase. Journal of Applied Physiology 91, 2579–2586. https://doi.org/10.1152/jappl.2001.91.6.2579
  • Shilpa, N., Itagi, V., Rani, R., 2018. A Study of Hemoglobin Concentration in Different Phases of Menstrual Cycle. International Journal of Physiology 6, 90. https://doi.org/10.5958/2320-608x.2018.00059.8
  • Thiyagarajan, D.K., Jeanmonod, R., 2019. Physiology, Menstrual Cycle, StatPearls. StatPearls Publishing.
  • Thongngarm, T., Jenkins, J.K., Ndebele, K., McMurray, R.W., 2003. Estrogen and progesterone modulate monocyte cell cycle progression and apoptosis. American Journal of Reproductive Immunology 49, 129–138. https://doi.org/10.1034/j.1600-0897.2003.00015.x
  • Tikare, S.N., Das, K.K., Dhundasi, S.A., 2008. Blood leukocyte profile in different phases of menstrual cycle. Indian J Physiol Pharmacol 52, 201–204.
  • Tindall VR, 1987. Jeffcoate’s principles of Gynecology, 5th ed. Butterworth-Heinemann & Co Ltd, London.
  • Treloar, A.E., Boynton, R.E., Behn, B.G., Brown, B.W., 1970. Variation of the human menstrual cycle through reproductive life. International Journal of Fertility 12, 77–126.
  • Usha Rani M D, Y.S., Manjunath N B, P.D., D, Knn.M., 2014. Comparative Study of Hematological and Biochemical Parameters during Different Phases of Menstrual Cycle in Young Healthy Women Aged 18-22 Years, IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN 9, 09-11. http://www.iosrjournals.org/iosr-jdms/papers/Vol9-issue2/B0920911.pdf
  • Van Den Heuvel, M.J., Horrocks, J., Bashar, S., Taylor, S., Burke, S., Hatta, K., Lewis, J.E., Croy, B.A., 2005. Menstrual cycle hormones induce changes in functional interactions between lymphocytes and decidual vascular endothelial cells. Journal of Clinical Endocrinology and Metabolism 90, 2835–2842. https://doi.org/10.1210/jc.2004-1742.
There are 26 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Clinical Research
Authors

Vijayashri Basavaraj Hanchinal 0000-0002-4967-2137

Ambhuja Sambranı This is me 0000-0001-9377-5523

Vineet Baljoshi This is me 0000-0002-3525-0144

Publication Date May 1, 2021
Submission Date January 12, 2021
Acceptance Date January 30, 2021
Published in Issue Year 2021 Volume: 38 Issue: 3

Cite

APA Hanchinal, V. B., Sambranı, A., & Baljoshi, V. (2021). A Study on Influence of Different Phases of Menstrual Cycle on Hematological Parameters. Journal of Experimental and Clinical Medicine, 38(3), 308-311.
AMA Hanchinal VB, Sambranı A, Baljoshi V. A Study on Influence of Different Phases of Menstrual Cycle on Hematological Parameters. J. Exp. Clin. Med. May 2021;38(3):308-311.
Chicago Hanchinal, Vijayashri Basavaraj, Ambhuja Sambranı, and Vineet Baljoshi. “A Study on Influence of Different Phases of Menstrual Cycle on Hematological Parameters”. Journal of Experimental and Clinical Medicine 38, no. 3 (May 2021): 308-11.
EndNote Hanchinal VB, Sambranı A, Baljoshi V (May 1, 2021) A Study on Influence of Different Phases of Menstrual Cycle on Hematological Parameters. Journal of Experimental and Clinical Medicine 38 3 308–311.
IEEE V. B. Hanchinal, A. Sambranı, and V. Baljoshi, “A Study on Influence of Different Phases of Menstrual Cycle on Hematological Parameters”, J. Exp. Clin. Med., vol. 38, no. 3, pp. 308–311, 2021.
ISNAD Hanchinal, Vijayashri Basavaraj et al. “A Study on Influence of Different Phases of Menstrual Cycle on Hematological Parameters”. Journal of Experimental and Clinical Medicine 38/3 (May 2021), 308-311.
JAMA Hanchinal VB, Sambranı A, Baljoshi V. A Study on Influence of Different Phases of Menstrual Cycle on Hematological Parameters. J. Exp. Clin. Med. 2021;38:308–311.
MLA Hanchinal, Vijayashri Basavaraj et al. “A Study on Influence of Different Phases of Menstrual Cycle on Hematological Parameters”. Journal of Experimental and Clinical Medicine, vol. 38, no. 3, 2021, pp. 308-11.
Vancouver Hanchinal VB, Sambranı A, Baljoshi V. A Study on Influence of Different Phases of Menstrual Cycle on Hematological Parameters. J. Exp. Clin. Med. 2021;38(3):308-11.