Review
BibTex RIS Cite
Year 2022, Volume: 39 Issue: 4, 1249 - 1254, 29.10.2022

Abstract

References

  • 1. Galie N, McLaughlin VV, Rubin LJ, et al. An overview of the 6th World Symposium on Pulmonary Hypertension. Eur. Respir. J. 2019; 53:1802148.
  • 2. Galie N, HumbertM,Vachiery JL, et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur. Respir. J. 2015; 46:903–975.
  • 3. Simonneau G, Galie N, Rubin LJ, et al. Clinical classification of pulmonary hypertension. J Am CollCardiol 2004; 43: Suppl. 12, 5S–12S.
  • 4. Iannuzzi GL, D'Alto M, Formisano R, Maniscalco M. Biomarkers in clinical management of pulmonary hypertension: has the emperor no clothes? A call for action. Biomark Med. 2019; 13(4):235-238. doi: 10.2217/bmm-2018-0491. Epub 2019 Mar 18. PMID: 30883210.
  • 5. Ho JE, Liu C, Lyass A, et al. Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the community. J Am CollCardiol. 2012;60:1249–56.
  • 6. Brinchmann MF, Patel DM, Iversen MH. The role of galectins as modulators of metabolism and inflammation.Mediators Inflamm.2018: 9186940.
  • 7. van Kimmenade RR, Januzzi JL, Ellinor PT, et al. Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure. Journal of the American College of Cardiology. 2006;48(6):1217–24. doi:10.1016/j.jacc.2006.03.061. PMID 16979009.
  • 8. Lok DJ, Van Der Meer P, de la Porte PW, et al. Prognostic value of galectin-3, a novel marker of fibrosis, in patients with chronic heart failure: data from the DEAL-HF study. Clinical Research in Cardiology. 2010; 99(5): 323–8.
  • 9. de Boer RA, Voors AA, Muntendam P, et al. Galectin-3: a novel mediator of heart failure development and progression. European Journal of Heart Failure. 2009; 11(9):811–7
  • 10. Fenster BE, Lasalvia L, Schroeder JD, et al. Galectin-3 levels are associated with right ventricular functional and morphologic changes in pulmonary arterial hypertension. Heart Vessels.2016;31:939–46.
  • 11. Li L, Li J, Gao J. Functions of galectin-3 and its role in fibrotic diseases. J PharmacolExpTher.2014;351:336–43.
  • 12. Calvier L, Legchenko E, Grimm L, et al. Galectin-3 and aldosterone as potential tandem biomarkers in pulmonary arterial hypertension. Heart 2016; 102:390–396.
  • 13. Mazurek JA, Horne BD, Saeed W, et al. Galectin-3 Levels Are Elevated and Predictive of Mortality in Pulmonary Hypertension. Heart Lung Circ. 2017; 26:1208–1215.
  • 14. Geenen LW, Baggen VJM, Koudstaal T, et al. The prognostic value of various biomarkers in adults with pulmonary hypertension; a multi-biomarker approach.Am. Heart J. 2019; 208:91–99.
  • 15. Weinberg EO, Shimpo M, De KeulenaerGW,et al. Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction. Circulation 2002;106:2961–2966.
  • 16. Sanada S, Hakuno D, Higgins LJ, et al. IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system. J Clin Invest 2007;117:1538-49.
  • 17. Carlomagno G, Messalli G, Melillo RM, et al. Serum soluble ST2 and interleukin-33 levels in patients with pulmonary arterial hypertension. Int. J. Cardiol. 2013; 168:1545–1547.
  • 18. Banaszkiewicz M, Pietrasik A, Darocha S, et al. Soluble ST2 protein as a new biomarker in patientswith precapillary pulmonary hypertension. Archives of Medical Science. 2020. doi:10.5114/aoms.2020.98635.
  • 19. Geenen LW, Baggen VJM, Kauling RM, et al.The Prognostic Value of Soluble ST2 in Adults with Pulmonary Hypertension. J. Clin. Med. 2019; 8:1517.
  • 20. Zheng YG, Yang T, He JG,et al. Plasma soluble ST2 levels correlatewith disease severity and predict clinical worsening in patients with pulmonary arterial hypertension. Clin.Cardiol.2014; 37:365–370.
  • 21.Banaszkiewicz M, Pietrasik A, Florczyk M, et al. Soluble ST2 as a Biomarker for Early Complications in Patients with Chronic Thromboembolic PulmonaryHypertension Treated with Balloon Pulmonary Angioplasty. Diagnostics 2021; 11:133.
  • 22. Kolditz M, Seyfarth H-J, Wilkens H et al. MR-proADM predicts exercise capacity andsurvival superior to other biomarkers in PH. Lung. 2015;193:901–10.
  • 23. Kümpers P, Nickel N, Lukasz A, et al. Circulating angiopoietinsinidiopathic pulmonary arterial hypertension. Eur Heart J. 2010;31:2291–300.
  • 24. Maisel A, Mueller C, Nowak R, et al. Mid-region pro-hormonemarkers for diagnosis and prognosis in acute dyspnea: results from the BACH(Biomarkers in Acute Heart Failure) trial. J Am CollCardiol. 2010;55:2062–76.
  • 25.Khan SQ, O’Brien RJ, Struck J, et al. Prognostic value of midregional pro-adrenomedullinin patients with acute myocardial infarction: the LAMP (Leicester AcuteMyocardial Infarction Peptide) study. J Am CollCardiol. 2007;49:1525–32.
  • 26.Krüger S, Ewig S, Giersdorf S, Hartmann O, Suttorp N, Welte T, and GermanCompetence Network for the Study of Community Acquired Pneumonia(CAPNETZ) Study Group. Cardiovascular and inflammatory biomarkers topredict short- and long-term survival in community-acquired pneumonia:Results from the German Competence Network, CAPNETZ. Am J RespirCritCare Med. 2010;182:1426–34.
  • 27.Langleben D, Orfanos SE, Giovinazzo M, et al. Acute vasodilator responsiveness and microvascular recruitment in idiopathic pulmonary arterial hypertension.Ann Intern Med. 2015; 162:154–6.
  • 28. Gaggin HK, Januzzi JL. Cardiac Biomarkers and Heart Failure. Expert Analysis. Latest in Cardiology. American Colledge of Cardiology. Feb 10 2015: https://www.acc.org/%2Flatest-in cardiology%2Farticles%2F2015%2F02%2F09%2F13%2F00%2Fcardiac-biomarkers-and-heart-failure.
  • 29. Acher R, Chauvet J, Rouille Y. Dynamic processing of neuropeptides: sequential conformation shaping of neurohypophysial preprohormones during intraneuronal secretory transport". Journal of Molecular Neuroscience. 2002; 18(3): 223–8.
  • 30. D’Alonzo GE, Barst RJ, Ayres SM, et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry.Ann.Intern. Med. 1991; 115: 343–349.
  • 31. Shah SJ, Thenappan T, Rich S, et al. Association of serum creatinine with abnormalhemodynamics and mortality in pulmonary arterial hypertension. Circulation. 2008; 117: 2475–2483.
  • 33. Nickel NP, Lichtinghagen R, Golpon H, et al. Circulating levels of copeptin predict outcome in patients with pulmonary arterial hypertension. Respir.Res. 2013; 14, 130.
  • 34. Kociol RD, Horton JR, Fonarow GC, et al. Admission, discharge, or change in B-type natriuretic peptide and long-term outcomes: data from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF) linked to Medicare claims. Circ Heart Fail. 2011;4:628-36.
  • 35. Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of American College of Cardiology/American Heart Associaton Task Force on Practice Guidelines.J Am CollCardiol. 2013;62:e147-239
  • 36. Galie N, Humbert M, Vachiery JL, et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur. Respir. J. 2015; 46: 903–975.
  • 37. Benza RL, Miller DP, Barst RJ, et al. An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL Registry. Chest 2012; 142:448–456.
  • 38. Chin KM, Rubin LJ, Channick R, et al. Association of N-Terminal Pro Brain Natriuretic Peptide and Long-Term Outcome in Patients With Pulmonary Arterial Hypertension. Circulation 2019; 139: 2440–2450.
  • 39. Galie N, Jansa P, Pulido T, et al. SERAPHIN haemodynamic substudy: The effect of the dual endothelin receptor antagonist macitentan on haemodynamic parameters and NT-proBNP levels and their association with disease progression in patients with pulmonary arterial hypertension. Eur. Heart J. 2017; 38:1147–1155.
  • 40. Berghaus TM, Kutsch J, Faul C,et al. The association of N-terminal pro-brain-type natriuretic peptide with hemodynamics and functional capacity in therapy-naive precapillary pulmonary hypertension: Results from a cohort study. BMC Pulm. Med. 2017; 17:167.
  • 41. Souza R, Jardim C, FernandesCJC,et al. NT-proBNP as a tool to stratify disease severity in pulmonary arterial hypertension. Respir.Med. 2007; 101: 69–75.
  • 42. Fijalkowska A, Kurzyna M, Torbicki A, et al. Serum N-terminal brain natriuretic peptide as a prognostic parameter in patients with pulmonary hypertension. Chest 2006; 129:1313–1321.
  • 43. Benza RL, Gomberg-Maitland M, Elliott CG, et al. Predicting Survival in Patients With Pulmonary Arterial Hypertension: The REVEAL Risk Score Calculator 2.0 and ComparisonWith ESC/ERS-Based Risk Assessment Strategies. Chest 2019; 156:323–337.
  • 44. Nagaya N, Ando M, Oya H, et al. Plasma brain natriuretic peptide as a noninvasive marker for efficacy of pulmonary thromboendarterectomy. Ann. Thorac. Surg. 2002; 74:180–184.
  • 45. Surie S, Reesink HJ, van der Plas MN, et al. Plasma brain natriuretic peptide as a biomarker for haemodynamic outcome and mortality following pulmonary endarterectomyfor chronic thromboembolic pulmonary hypertension. Interact. Cardiovasc.Thorac.Surg. 2012; 15:973–978.
  • 46. Kriechbaum SD, Wiedenroth CB, Wolter JS, et al. N-terminal pro-B-type natriuretic peptide for monitoring after balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension. J. Heart Lung Transplant. 2018; 37:639–646.
  • 47.Collet JP, Thiele H, Barbato E, et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Rev. Esp. Cardiol. 2021; 74,544.
  • 48. Eggers KM, Lagerqvist B, Venge P, et al. Persistent cardiac troponin I elevation in stabilized patients after an episode of acute coronary syndrome predicts long-term mortality. Circulation 2007; 116:1907–1914.
  • 49. de Lemos JA, Drazner MH, Omland T, et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA.2010; 304:2503–2512.
  • 50. Apple FS, Murakami MM, Pearce LA, Herzog CA. Predictive value of cardiac troponin I and T for subsequent death in end-stage renal disease. Circulation 2002; 106:2941–2945.
  • 51. Horwich TB, Patel J, MacLellanWR,Fonarow GC. Cardiac troponin I is associated with impaired hemodynamics, progressive left ventricular dysfunction, and increased mortality rates in advanced heart failure. Circulation 2003; 108:833–838.
  • 52. Banaszkiewicz M, Gasecka A, Darocha S, et al. Circulating Blood-Based Biomarkers in Pulmonary Hypertension. J. Clin.Med. 2022; 11: 383. https://doi.org/10.3390/jcm11020383.
  • 53. Torbicki A, Kurzyna M, Kuca P, et al. Detectable serum cardiac troponin T as a marker of poor prognosis among patients with chronic precapillary pulmonary hypertension. Circulation 2003; 108:844–848.
  • 54. Velez-Martinez M, Ayers C, Mishkin JD, et al. Association of cardiac troponin I with disease severity and outcomes in patients with pulmonary hypertension. Am. J. Cardiol. 2013; 111:1812–1817.
  • 55. Heresi GA, Tang WH, Aytekin M, et al. Sensitive cardiac troponin I predicts poor outcomes in pulmonary arterial hypertension. Eur. Respir. J. 2012; 39:939–944.
  • 56. Kriechbaum SD, Wiedenroth CB, Keller T, et al. Dynamics of high-sensitivity cardiac troponin T during therapy with balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension.PLoS ONE 2018; 13: e0204683.
  • 57. Ozerol IH, Pac FA, Ozerol E, et al. Plasma endothelin-1, homocysteine and serum nitric oxide values in patients with left-to-right shunt. Indian Heart J. 2004;56:653–7.
  • 58. Sanli C, Oguz D, Olgunturk R, et al. Elevated homocysteine and asymmetric dimethyl arginine levels in pulmonary hypertension associated with congenital heart disease. Pediatr.Cardiol.2012; 33: 1323–1331.
  • 59. Hoffmann U, Espeter F, Weiss C, et al. Ischemicbiomarker heart-type fatty acid bindingprotein (hFABP) in acute heart failure- diagnostic and prognostic insights comparedto NT-proBNP and troponin I. BMCCardiovascDisord 2015;15:50. doi:10.1186/s12872-015-0026-0.
  • 60. Niizeki T, Takeishi Y, Arimoto T, et al. Persistently increasedserum concentration of heart-type fatty acid-binding protein predicts adverse clinicaloutcomes in patients with chronic heartfailure. Circ J2008;72:109–114.
  • 61. Carroll C, Al Khalaf M, Stevens JW, et al. Heart-type fatty acid binding protein asan early marker for myocardial infarction: Systematic review and meta-analysis. Emerg.Med. J. 2013; 30:280–286.
  • 62. Lankeit M, Dellas C, Panzenbock A, et al. Heart-type fatty acid-binding protein for risk assessment of chronic thromboembolic pulmonary hypertension. Eur.Respir. J. 2008; 31:1024–1029.
  • 63. Kanwar MK. Biomarkers in pulmonary arterial hypertension: Moving closer toward precision medicine? J Heart Lung Transplant. 2020; 39(4):287-288. doi: 10.1016/j.healun.2020.02.020. Epub 2020 Feb 29. PMID: 32199588.

Cardiovascular biomarkers in pulmonary hypertension- current applications and future directions

Year 2022, Volume: 39 Issue: 4, 1249 - 1254, 29.10.2022

Abstract

Biomarkers are non-invasive tools, which can be very useful in diagnosis and prognosis of a specific disease. Pulmonary hypertension (PH) is a serious health condition, characterized by increased pulmonary arterial pressure, elevated pulmonary vascular resistance often leading to right heart failure. It may significantly worse patients’ life quality and lead to lethal outcome if not treated properly. Nowadays, there is an increasing interest on PH markers and more specifically how they can contribute in the diagnosis, prognosis and monitoring of the development of this disease. Recent studies on biomarkers in PH suggest several novel and promising molecules, which can be potentially useful in PH work-up and follow-up strategies. This review focuses on biomarkers for diagnosis and prognosis of PH via well-known and some novel cardiovascular disease (CVD) indicators associated with heart failure, myocardial remodelling and injury. Current understandings assume that CVD biomarkers can indicate not only heart abnormalities, but also pulmonary vascular system injury.

References

  • 1. Galie N, McLaughlin VV, Rubin LJ, et al. An overview of the 6th World Symposium on Pulmonary Hypertension. Eur. Respir. J. 2019; 53:1802148.
  • 2. Galie N, HumbertM,Vachiery JL, et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur. Respir. J. 2015; 46:903–975.
  • 3. Simonneau G, Galie N, Rubin LJ, et al. Clinical classification of pulmonary hypertension. J Am CollCardiol 2004; 43: Suppl. 12, 5S–12S.
  • 4. Iannuzzi GL, D'Alto M, Formisano R, Maniscalco M. Biomarkers in clinical management of pulmonary hypertension: has the emperor no clothes? A call for action. Biomark Med. 2019; 13(4):235-238. doi: 10.2217/bmm-2018-0491. Epub 2019 Mar 18. PMID: 30883210.
  • 5. Ho JE, Liu C, Lyass A, et al. Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the community. J Am CollCardiol. 2012;60:1249–56.
  • 6. Brinchmann MF, Patel DM, Iversen MH. The role of galectins as modulators of metabolism and inflammation.Mediators Inflamm.2018: 9186940.
  • 7. van Kimmenade RR, Januzzi JL, Ellinor PT, et al. Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure. Journal of the American College of Cardiology. 2006;48(6):1217–24. doi:10.1016/j.jacc.2006.03.061. PMID 16979009.
  • 8. Lok DJ, Van Der Meer P, de la Porte PW, et al. Prognostic value of galectin-3, a novel marker of fibrosis, in patients with chronic heart failure: data from the DEAL-HF study. Clinical Research in Cardiology. 2010; 99(5): 323–8.
  • 9. de Boer RA, Voors AA, Muntendam P, et al. Galectin-3: a novel mediator of heart failure development and progression. European Journal of Heart Failure. 2009; 11(9):811–7
  • 10. Fenster BE, Lasalvia L, Schroeder JD, et al. Galectin-3 levels are associated with right ventricular functional and morphologic changes in pulmonary arterial hypertension. Heart Vessels.2016;31:939–46.
  • 11. Li L, Li J, Gao J. Functions of galectin-3 and its role in fibrotic diseases. J PharmacolExpTher.2014;351:336–43.
  • 12. Calvier L, Legchenko E, Grimm L, et al. Galectin-3 and aldosterone as potential tandem biomarkers in pulmonary arterial hypertension. Heart 2016; 102:390–396.
  • 13. Mazurek JA, Horne BD, Saeed W, et al. Galectin-3 Levels Are Elevated and Predictive of Mortality in Pulmonary Hypertension. Heart Lung Circ. 2017; 26:1208–1215.
  • 14. Geenen LW, Baggen VJM, Koudstaal T, et al. The prognostic value of various biomarkers in adults with pulmonary hypertension; a multi-biomarker approach.Am. Heart J. 2019; 208:91–99.
  • 15. Weinberg EO, Shimpo M, De KeulenaerGW,et al. Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction. Circulation 2002;106:2961–2966.
  • 16. Sanada S, Hakuno D, Higgins LJ, et al. IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system. J Clin Invest 2007;117:1538-49.
  • 17. Carlomagno G, Messalli G, Melillo RM, et al. Serum soluble ST2 and interleukin-33 levels in patients with pulmonary arterial hypertension. Int. J. Cardiol. 2013; 168:1545–1547.
  • 18. Banaszkiewicz M, Pietrasik A, Darocha S, et al. Soluble ST2 protein as a new biomarker in patientswith precapillary pulmonary hypertension. Archives of Medical Science. 2020. doi:10.5114/aoms.2020.98635.
  • 19. Geenen LW, Baggen VJM, Kauling RM, et al.The Prognostic Value of Soluble ST2 in Adults with Pulmonary Hypertension. J. Clin. Med. 2019; 8:1517.
  • 20. Zheng YG, Yang T, He JG,et al. Plasma soluble ST2 levels correlatewith disease severity and predict clinical worsening in patients with pulmonary arterial hypertension. Clin.Cardiol.2014; 37:365–370.
  • 21.Banaszkiewicz M, Pietrasik A, Florczyk M, et al. Soluble ST2 as a Biomarker for Early Complications in Patients with Chronic Thromboembolic PulmonaryHypertension Treated with Balloon Pulmonary Angioplasty. Diagnostics 2021; 11:133.
  • 22. Kolditz M, Seyfarth H-J, Wilkens H et al. MR-proADM predicts exercise capacity andsurvival superior to other biomarkers in PH. Lung. 2015;193:901–10.
  • 23. Kümpers P, Nickel N, Lukasz A, et al. Circulating angiopoietinsinidiopathic pulmonary arterial hypertension. Eur Heart J. 2010;31:2291–300.
  • 24. Maisel A, Mueller C, Nowak R, et al. Mid-region pro-hormonemarkers for diagnosis and prognosis in acute dyspnea: results from the BACH(Biomarkers in Acute Heart Failure) trial. J Am CollCardiol. 2010;55:2062–76.
  • 25.Khan SQ, O’Brien RJ, Struck J, et al. Prognostic value of midregional pro-adrenomedullinin patients with acute myocardial infarction: the LAMP (Leicester AcuteMyocardial Infarction Peptide) study. J Am CollCardiol. 2007;49:1525–32.
  • 26.Krüger S, Ewig S, Giersdorf S, Hartmann O, Suttorp N, Welte T, and GermanCompetence Network for the Study of Community Acquired Pneumonia(CAPNETZ) Study Group. Cardiovascular and inflammatory biomarkers topredict short- and long-term survival in community-acquired pneumonia:Results from the German Competence Network, CAPNETZ. Am J RespirCritCare Med. 2010;182:1426–34.
  • 27.Langleben D, Orfanos SE, Giovinazzo M, et al. Acute vasodilator responsiveness and microvascular recruitment in idiopathic pulmonary arterial hypertension.Ann Intern Med. 2015; 162:154–6.
  • 28. Gaggin HK, Januzzi JL. Cardiac Biomarkers and Heart Failure. Expert Analysis. Latest in Cardiology. American Colledge of Cardiology. Feb 10 2015: https://www.acc.org/%2Flatest-in cardiology%2Farticles%2F2015%2F02%2F09%2F13%2F00%2Fcardiac-biomarkers-and-heart-failure.
  • 29. Acher R, Chauvet J, Rouille Y. Dynamic processing of neuropeptides: sequential conformation shaping of neurohypophysial preprohormones during intraneuronal secretory transport". Journal of Molecular Neuroscience. 2002; 18(3): 223–8.
  • 30. D’Alonzo GE, Barst RJ, Ayres SM, et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry.Ann.Intern. Med. 1991; 115: 343–349.
  • 31. Shah SJ, Thenappan T, Rich S, et al. Association of serum creatinine with abnormalhemodynamics and mortality in pulmonary arterial hypertension. Circulation. 2008; 117: 2475–2483.
  • 33. Nickel NP, Lichtinghagen R, Golpon H, et al. Circulating levels of copeptin predict outcome in patients with pulmonary arterial hypertension. Respir.Res. 2013; 14, 130.
  • 34. Kociol RD, Horton JR, Fonarow GC, et al. Admission, discharge, or change in B-type natriuretic peptide and long-term outcomes: data from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF) linked to Medicare claims. Circ Heart Fail. 2011;4:628-36.
  • 35. Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of American College of Cardiology/American Heart Associaton Task Force on Practice Guidelines.J Am CollCardiol. 2013;62:e147-239
  • 36. Galie N, Humbert M, Vachiery JL, et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur. Respir. J. 2015; 46: 903–975.
  • 37. Benza RL, Miller DP, Barst RJ, et al. An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL Registry. Chest 2012; 142:448–456.
  • 38. Chin KM, Rubin LJ, Channick R, et al. Association of N-Terminal Pro Brain Natriuretic Peptide and Long-Term Outcome in Patients With Pulmonary Arterial Hypertension. Circulation 2019; 139: 2440–2450.
  • 39. Galie N, Jansa P, Pulido T, et al. SERAPHIN haemodynamic substudy: The effect of the dual endothelin receptor antagonist macitentan on haemodynamic parameters and NT-proBNP levels and their association with disease progression in patients with pulmonary arterial hypertension. Eur. Heart J. 2017; 38:1147–1155.
  • 40. Berghaus TM, Kutsch J, Faul C,et al. The association of N-terminal pro-brain-type natriuretic peptide with hemodynamics and functional capacity in therapy-naive precapillary pulmonary hypertension: Results from a cohort study. BMC Pulm. Med. 2017; 17:167.
  • 41. Souza R, Jardim C, FernandesCJC,et al. NT-proBNP as a tool to stratify disease severity in pulmonary arterial hypertension. Respir.Med. 2007; 101: 69–75.
  • 42. Fijalkowska A, Kurzyna M, Torbicki A, et al. Serum N-terminal brain natriuretic peptide as a prognostic parameter in patients with pulmonary hypertension. Chest 2006; 129:1313–1321.
  • 43. Benza RL, Gomberg-Maitland M, Elliott CG, et al. Predicting Survival in Patients With Pulmonary Arterial Hypertension: The REVEAL Risk Score Calculator 2.0 and ComparisonWith ESC/ERS-Based Risk Assessment Strategies. Chest 2019; 156:323–337.
  • 44. Nagaya N, Ando M, Oya H, et al. Plasma brain natriuretic peptide as a noninvasive marker for efficacy of pulmonary thromboendarterectomy. Ann. Thorac. Surg. 2002; 74:180–184.
  • 45. Surie S, Reesink HJ, van der Plas MN, et al. Plasma brain natriuretic peptide as a biomarker for haemodynamic outcome and mortality following pulmonary endarterectomyfor chronic thromboembolic pulmonary hypertension. Interact. Cardiovasc.Thorac.Surg. 2012; 15:973–978.
  • 46. Kriechbaum SD, Wiedenroth CB, Wolter JS, et al. N-terminal pro-B-type natriuretic peptide for monitoring after balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension. J. Heart Lung Transplant. 2018; 37:639–646.
  • 47.Collet JP, Thiele H, Barbato E, et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Rev. Esp. Cardiol. 2021; 74,544.
  • 48. Eggers KM, Lagerqvist B, Venge P, et al. Persistent cardiac troponin I elevation in stabilized patients after an episode of acute coronary syndrome predicts long-term mortality. Circulation 2007; 116:1907–1914.
  • 49. de Lemos JA, Drazner MH, Omland T, et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA.2010; 304:2503–2512.
  • 50. Apple FS, Murakami MM, Pearce LA, Herzog CA. Predictive value of cardiac troponin I and T for subsequent death in end-stage renal disease. Circulation 2002; 106:2941–2945.
  • 51. Horwich TB, Patel J, MacLellanWR,Fonarow GC. Cardiac troponin I is associated with impaired hemodynamics, progressive left ventricular dysfunction, and increased mortality rates in advanced heart failure. Circulation 2003; 108:833–838.
  • 52. Banaszkiewicz M, Gasecka A, Darocha S, et al. Circulating Blood-Based Biomarkers in Pulmonary Hypertension. J. Clin.Med. 2022; 11: 383. https://doi.org/10.3390/jcm11020383.
  • 53. Torbicki A, Kurzyna M, Kuca P, et al. Detectable serum cardiac troponin T as a marker of poor prognosis among patients with chronic precapillary pulmonary hypertension. Circulation 2003; 108:844–848.
  • 54. Velez-Martinez M, Ayers C, Mishkin JD, et al. Association of cardiac troponin I with disease severity and outcomes in patients with pulmonary hypertension. Am. J. Cardiol. 2013; 111:1812–1817.
  • 55. Heresi GA, Tang WH, Aytekin M, et al. Sensitive cardiac troponin I predicts poor outcomes in pulmonary arterial hypertension. Eur. Respir. J. 2012; 39:939–944.
  • 56. Kriechbaum SD, Wiedenroth CB, Keller T, et al. Dynamics of high-sensitivity cardiac troponin T during therapy with balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension.PLoS ONE 2018; 13: e0204683.
  • 57. Ozerol IH, Pac FA, Ozerol E, et al. Plasma endothelin-1, homocysteine and serum nitric oxide values in patients with left-to-right shunt. Indian Heart J. 2004;56:653–7.
  • 58. Sanli C, Oguz D, Olgunturk R, et al. Elevated homocysteine and asymmetric dimethyl arginine levels in pulmonary hypertension associated with congenital heart disease. Pediatr.Cardiol.2012; 33: 1323–1331.
  • 59. Hoffmann U, Espeter F, Weiss C, et al. Ischemicbiomarker heart-type fatty acid bindingprotein (hFABP) in acute heart failure- diagnostic and prognostic insights comparedto NT-proBNP and troponin I. BMCCardiovascDisord 2015;15:50. doi:10.1186/s12872-015-0026-0.
  • 60. Niizeki T, Takeishi Y, Arimoto T, et al. Persistently increasedserum concentration of heart-type fatty acid-binding protein predicts adverse clinicaloutcomes in patients with chronic heartfailure. Circ J2008;72:109–114.
  • 61. Carroll C, Al Khalaf M, Stevens JW, et al. Heart-type fatty acid binding protein asan early marker for myocardial infarction: Systematic review and meta-analysis. Emerg.Med. J. 2013; 30:280–286.
  • 62. Lankeit M, Dellas C, Panzenbock A, et al. Heart-type fatty acid-binding protein for risk assessment of chronic thromboembolic pulmonary hypertension. Eur.Respir. J. 2008; 31:1024–1029.
  • 63. Kanwar MK. Biomarkers in pulmonary arterial hypertension: Moving closer toward precision medicine? J Heart Lung Transplant. 2020; 39(4):287-288. doi: 10.1016/j.healun.2020.02.020. Epub 2020 Feb 29. PMID: 32199588.
There are 62 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Review Articles
Authors

Asparuh Nikolov 0000-0003-4289-5124

Pavlina Glogovska 0000-0003-2910-9707

Publication Date October 29, 2022
Submission Date August 7, 2022
Acceptance Date August 16, 2022
Published in Issue Year 2022 Volume: 39 Issue: 4

Cite

APA Nikolov, A., & Glogovska, P. (2022). Cardiovascular biomarkers in pulmonary hypertension- current applications and future directions. Journal of Experimental and Clinical Medicine, 39(4), 1249-1254.
AMA Nikolov A, Glogovska P. Cardiovascular biomarkers in pulmonary hypertension- current applications and future directions. J. Exp. Clin. Med. October 2022;39(4):1249-1254.
Chicago Nikolov, Asparuh, and Pavlina Glogovska. “Cardiovascular Biomarkers in Pulmonary Hypertension- Current Applications and Future Directions”. Journal of Experimental and Clinical Medicine 39, no. 4 (October 2022): 1249-54.
EndNote Nikolov A, Glogovska P (October 1, 2022) Cardiovascular biomarkers in pulmonary hypertension- current applications and future directions. Journal of Experimental and Clinical Medicine 39 4 1249–1254.
IEEE A. Nikolov and P. Glogovska, “Cardiovascular biomarkers in pulmonary hypertension- current applications and future directions”, J. Exp. Clin. Med., vol. 39, no. 4, pp. 1249–1254, 2022.
ISNAD Nikolov, Asparuh - Glogovska, Pavlina. “Cardiovascular Biomarkers in Pulmonary Hypertension- Current Applications and Future Directions”. Journal of Experimental and Clinical Medicine 39/4 (October 2022), 1249-1254.
JAMA Nikolov A, Glogovska P. Cardiovascular biomarkers in pulmonary hypertension- current applications and future directions. J. Exp. Clin. Med. 2022;39:1249–1254.
MLA Nikolov, Asparuh and Pavlina Glogovska. “Cardiovascular Biomarkers in Pulmonary Hypertension- Current Applications and Future Directions”. Journal of Experimental and Clinical Medicine, vol. 39, no. 4, 2022, pp. 1249-54.
Vancouver Nikolov A, Glogovska P. Cardiovascular biomarkers in pulmonary hypertension- current applications and future directions. J. Exp. Clin. Med. 2022;39(4):1249-54.