SCUBE-1 is a newly identified, secreted cell surface protein that is determined during early embryogenesis. This protein consists of cascading EGF-like repeats following the N-terminal signal peptide sequence, a spacer region, cysteine-rich repeat motifs, and a CUB domain at the C-terminus. These molecules are stored in alpha granules in inactivated platelets, translocated to the platelet surface after activation by thrombin, secreted as small soluble fragments, and incorporated into the thrombus.
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Letter to Editor |
| Authors | |
| Early Pub Date | March 18, 2023 |
| Publication Date | March 18, 2023 |
| Submission Date | December 7, 2022 |
| Acceptance Date | January 26, 2023 |
| Published in Issue | Year 2023 Volume: 40 Issue: 1 |

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