Effects of DASH dietary and exercise on metabolic parameters in prehypertensive patients

Year 2018, Volume: 10 Issue: 2, 167 - 173, 01.06.2018

Yasemin Kaya , Harun Düğeroğlu , Ahmet Karataş , Muhammet Özbilen

https://doi.org/10.21601/ortadogutipdergisi.315813

Abstract

Objective: The aim of this study is to investigate the effects of
exercise and DASH (Dietary Approaches to Stop Hypertension) diet that is
proposed in order to control blood pressure and to prevent hypertension on
biochemical parameters in prehypertensive patients.

Material Method: Fifty two prehypertensive individuals were
included in the study. Patients with secondary hypertension, diabetes mellitus
and thyroid disorders and receiving antihypertensive treatment were excluded
from the study. At the beginning of the study, the height, weight, waist
circumference (BW), systolic and diastolic blood pressures of the individuals
were measured. Body mass indexes (BMI) were calculated. Fasting blood glucose, fasting
lipid levels, fasting serum  insulin,
hs-CRP, creatinine, homocysteine were analyzed. Insulin resistance was calculated
with The HOMA-IR formula and the glomerular filtration rate (GFR) was
calculated with the Modification of Diet in Renal Disease (MDRD) Formula. Oral
glucose tolerance test was performed. Microalbumin and urine creatinine were
measured in the spot urine. DASH diet and exercise were suggested to patients
during six months. Initial parameters were repeated at 6 month later.

Results: The
mean age of fifty-two patients was 38 ± 7.6 years and 67% were female. Systolic and diastolic blood pressures, weight, BW, BMI, total
cholesterol, LDL cholesterol, triglyceride, fasting insulin level, insulin
resistance and homocysteine decreased significantly and GFR increased
significantly after diet and exercise treatment (respectively; p<0.001,
p=0.003, p<0.001, p<0.001, p<0.001, p= 0.006, p=0.009, p=0.039,
p<0.001, p=0.003, p=0.001, p<0.001).

Conclusion: It has been shown that DASH diet and exercise
have corrective effects on metabolic parameters in prehypertensive individuals.

Keywords

Prehypertension, metabolic disorder, DASH diet

Prehipertansif hastalarda DASH diyeti ve egzersizin metabolik parametreler üzerine etkisi

Abstract

Amaç: Prehipertansif hastalarda kan basıncını kontrol altına almak ve
hipertansiyona gidişi önlemek için önerilen DASH (Dietary Approaches to Stop
Hypertension) diyeti ve egzersizin biyokimyasal parametreler üzerine etkisinin
olup olmadığının araştırılması amaçlandı. Materyal
Metod: Çalışmamıza 52 prehipertansif birey alındı. Sekonder hipertansiyonu,
diabetes mellitusu ve tiroid bozuklukları olanlar ile antihipertansif ilaç
kullananlar çalışma dışı bırakıldı. Çalışmanın başında bireylerin boy, kilo,
bel çevresi (BÇ), sistolik ve diastolik kan basınçları ölçüldü. Vücut kitle
indeksleri (VKI) hesaplandı. Biyokimyasal parametrelerden açlık serum glukozu, lipid
düzeyleri, açlık serum insülini, hs-CRP, kreatinin, homosistein çalışıldı.
HOMA-IR formülü ile insülin direnci ve MDRD (Modification of Diet in
Renal Disease) formülü ile glomerüler filtrasyon hızı (GFR)  hesaplandı. Oral glukoz tolerans testleri
yapıldı. Spot idrarda mikroalbumin ve idrar kreatinin ölçümü yapıldı. Hastalara
6 ay DASH diyeti ve egzersiz önerildi. Hastaların 6 ay sonra yapılan
kontrollerinde başlangıçta yapılan parametreler tekrar analiz edildi.

Bulgular: Elli iki hastanın yaş ortalaması 38±7.6 yıl idi ve  % 67’si kadındı. Diyet ve egzersiz tedavisi
sonrası sistolik ve diastolik kan basınçlarında, kilo, BÇ, VKI, total
kolesterol, LDL kolesterol, trigliserid, açlık insülin düzeyi, insülin
direncinde ve homosisteinde istatistiksel olarak anlamlı düşme, GFR de yükselme
bulundu (sırasıyla; p<0.001, p=0.003, p<0.001, p<0.001, p<0.001, p=
0.006, p=0.009, p=0.039, p<0.001, p=0.003, p=0.001, p<0.001).Sonuç: DASH diyeti ve egzersizin
prehipertansif bireylerde metabolik parametreleri düzeltici etkisi
gösterilmiştir.

Keywords

Prehipertansiyon, metabolik bozukluk, DASH diyeti

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