Evaluation of Total Oxidant and Total Antioxidant Status in Patients with Acne Vulgaris

Öz

Acne vulgaris is a common skin disease and has a complex pathogenesis. There is no enough data related with oxidative stress in acne vulgaris. We purposed to assess total oxidant and total antioxidant status in acne vulgaris. We included 32 acne patients and 35 healthy controls in this study. Global Acne Grading System (GAGS) scores were calculated. Serum total oxidant status (TOS) and total antioxidant status (TAS) levels were evaluated and oxidative stress index (OSI) was calculated by proportion of the TOS to the TAS. Mean GAGS scores of acne patients were 14.08 ± 5.72. Mean disease duration of acne patients was 33.97 ± 25.99 months. TAS, TOS and OSI were significantly higher in acne patients (p=0.010, p=0.021, p=0.015, respectively). TAS, TOS and OSI were not correlated with disease duration and GAGS scores (p>0.05). Both oxidant and antioxidant status increased in acne patients. The study showed that oxidative stress may play a role in pathogenesis of acne but it isn’t exactly known that is a cause or a result of acne. Advanced studies especially comparing mild to moderate and severe acne patients are required. In addition we consider that antioxidant agents may be beneficial in the treatment of acne.

Anahtar Kelimeler

• Acne vulgaris
• total oxidant status
• total antioxidant status
• oxidative stress

Akne Vulgarisli Hastalarda Total Oksidan ve Total Antioksidan Durumun Değerlendirilmesi

Öz

Akne vulgaris sık görülen bir deri hastalığıdır ve karmaşık bir patogeneze sahiptir. Literatürde, akne vulgarisde oksidatif stresin durumu ile ilgili yeterli veri yoktur. Bu çalışmada akne vulgarisli hastalarda total oksidan ve total antioksidan seviyenin değerlendirilmesi amaçlandı. Bu çalışmaya 32 akne vulgarisli hasta ve 35 sağlıklı kontrol dahil edildi. Global akne skorlama sistemi (GASS) skorları hesaplandı. Serum total oksidan seviye (TOS), total antioksidan seviye (TAS) ölçüldü ve TOS, TAS’a bölünerek oksidatif stres indeksi (OSİ) hesaplandı. Akne hastalarının ortalama GASS skoru 14.08 ± 5.72 idi. Akne hastalarının ortalama hastalık süresi 33.97 ± 25.99 ay idi. Akne hastalarında TAS, TOS ve OSİ daha yüksekti (p=0.010, p=0.021, p=0.015, sırasıyla). TAS, TOS ve OSİ ile hastalık süresi ve GASS skoru arasında bir ilişki yoktu (p>0.05). Bu çalışmada akne hastalarında oksidan ve antioksidan seviye yüksekti. Bu sonuç oksidatif stresin akne patogenezinde bir rolü olabileciğini düşündürmektedir. Ancak oksidatif stres aknenin nedeni mi yoksa sonucu mu olduğu tam olarak bilinmemektedir. Özellikle hafif-orta ve şiddetli akne hastalarında oksidatif stres durumunu karşılaştıran ileri çalışmaların yapılmasına ihtiyaç vardır. Ayrıca akne tedavisinde antioksidan ajanların faydalı olabileceğini düşünmekteyiz.

Anahtar Kelimeler

• Akne vulgaris
• total oksidan durum
• total antioksidan durum
• oksidatif stres

Kaynakça

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