Meme Kanseri Tedavisinde Potansiyel Bir Antineoplastik Ajan: Gallik Asit

Öz

Meme kanseri, dünya çapında kadınlarda kansere bağlı ölümlerin önde gelen nedenidir. Meme kanserinin görülme sıklığı gün geçtikçe daha da artmaktadır. Kanser tedavisinde kullanılan kemoterapotik ilaçlar ve diğerleri hedef hücrelerde ve sağlıklı hücrelerde etkin olduğundan, araştırmacılar meme kanseri tedavisi için yeni ajanlar geliştirmeye çalışmaktadır. Bu ajanlardan biri de oldukça umut vadeden birçok meyve ve sebzede bulunan doğal polifenolik bir molekül olan gallik asittir. Gallik asit üzerine yapılan çalışmalarda, gallik asitin A549 (akciğer kanseri hücre hattı) EBC-1, HTB 35(rahim ağzı kanseri hücre hattı) K-562 (miyeloid lösemi hücre hattı) MCF-7, MDA-MB-231 (meme kanseri hücre hattı) gibi birçok kanser hücre hattında apoptoz indükleyici, hücre döngüsü durdurucu, kanser oluşumunda rol oynayan çeşitli sinyal yolaklarını inhibe edici, anjiyogenezi ya da metastazı önleyici etkilerinin olduğu gözlemlenmiştir. Yapılan çalışmalarda gallik asidin evrensel kanser tedavisi ajanı olma potansiyeli taşıdığı ve kanser başta olmak üzere birçok hastalık üzerine etkilerinin araştırılmaya devam ettiği görülmektedir. Yaptığımız bu derlemede gallik asidin meme kanseri üzerindeki etkilerinin ve anti-kanser mekanizmasının gözden geçirilmesi amaçlanmıştır.

Anahtar Kelimeler

• gallik asit
• meme kanseri
• kombine tedavi
• polifenolik asit

A Potential Antineoplastic Agent in Breast Cancer Treatment: Gallic Acid

Öz

Breast cancer is the leading cause of cancer-related deaths in women worldwide. The incidence of breast cancer is increasing day by day. Since chemotherapeutic drugs and others used in cancer treatment are active in target cells and healthy cells, researchers are trying to develop new agents for breast cancer treatment. One of these agents is gallic acid, a natural polyphenolic molecule found in many promising fruits and vegetables. In studies on gallic acid, it has been observed that gallic acid has apoptosis-inducing, cell cycle arresting, inhibitory effects on various signaling pathways involved in cancer formation, inhibitory effects on angiogenesis or metastasis in many cancer cell lines such as A549 (lung cancer cell line) EBC-1, HTB 35 (cervical cancer cell line) K-562 (myeloid leukemia cell line) MCF-7, MDA-MB-231 (breast cancer cell line). Studies show that gallic acid has the potential to be a universal cancer treatment agent and its effects on many diseases, especially cancer, continue to be investigated. In this review, we aimed to review the effects of gallic acid on breast cancer and its anti-cancer mechanism.

Anahtar Kelimeler

• Gallic acid
• breast cancer
• combined therapy
• polyphenolic acid

Kaynakça

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