EN
TR
Donor-related EDTA dependent pseudothrombocytopenia after allogeneic stem cell transplantation. Can it be real?
Öz
Hematopoietic stem cell transplantation (HSCT) may take place in the form of an autologous or allogeneic transplant depending on the indication for transplantation. Because of the myeloablative conditioning regimens preceding HSCT, deep thrombocytopenia is experienced by most of the stem cell recipients in whom replenishment of leukocytes and platelets is expected within the first month following the transplantation. Prolonged thrombocytopenia, on the other hand, usually develops as a delayed complication of allogeneic stem cell transplantation (allo-SCT) and is associated to the source of stem cells, quantity of the infused CD34+ cells, graft-versus-host-disease (GVHD), insufficient engraftment, relapse of the malignancy, microangiopathy, alloimmunisation, medications, or viral infections. In an attempt to explain pathogenesis leading to post-HSCT thrombocytopenia, two main theories have been proposed. First one is the peripheral destruction caused by anti-platelet antibodies, splenic sequestration, or other factors. The latter blames insufficient platelet generation due to impaired thrombopoiesis. Nevertheless, most of the clinical conditions arise with overlapping of both mechanisms.Here we present a pseudothrombocytopenia case induced by donor-related ethylene-diamine-tetra-acetic acid (EDTA) as an unanticipated cause of thrombocytopenia to which most recipients of allo-SCT are prone to.
Anahtar Kelimeler
Ayrıntılar
Birincil Dil
İngilizce
Konular
Tıp Eğitimi
Bölüm
Editöre Mektup
Yayımlanma Tarihi
24 Ekim 2023
Gönderilme Tarihi
11 Temmuz 2023
Kabul Tarihi
11 Eylül 2023
Yayımlandığı Sayı
Yıl 2023 Cilt: 45 Sayı: 6
APA
Üsküdar Teke, H., & Gunduz, E. (2023). Donor-related EDTA dependent pseudothrombocytopenia after allogeneic stem cell transplantation. Can it be real? Osmangazi Tıp Dergisi, 45(6), 1011-1014. https://doi.org/10.20515/otd.1326098
AMA
1.Üsküdar Teke H, Gunduz E. Donor-related EDTA dependent pseudothrombocytopenia after allogeneic stem cell transplantation. Can it be real? Osmangazi Tıp Dergisi. 2023;45(6):1011-1014. doi:10.20515/otd.1326098
Chicago
Üsküdar Teke, Hava, ve Eren Gunduz. 2023. “Donor-related EDTA dependent pseudothrombocytopenia after allogeneic stem cell transplantation. Can it be real?”. Osmangazi Tıp Dergisi 45 (6): 1011-14. https://doi.org/10.20515/otd.1326098.
EndNote
Üsküdar Teke H, Gunduz E (01 Ekim 2023) Donor-related EDTA dependent pseudothrombocytopenia after allogeneic stem cell transplantation. Can it be real? Osmangazi Tıp Dergisi 45 6 1011–1014.
IEEE
[1]H. Üsküdar Teke ve E. Gunduz, “Donor-related EDTA dependent pseudothrombocytopenia after allogeneic stem cell transplantation. Can it be real?”, Osmangazi Tıp Dergisi, c. 45, sy 6, ss. 1011–1014, Eki. 2023, doi: 10.20515/otd.1326098.
ISNAD
Üsküdar Teke, Hava - Gunduz, Eren. “Donor-related EDTA dependent pseudothrombocytopenia after allogeneic stem cell transplantation. Can it be real?”. Osmangazi Tıp Dergisi 45/6 (01 Ekim 2023): 1011-1014. https://doi.org/10.20515/otd.1326098.
JAMA
1.Üsküdar Teke H, Gunduz E. Donor-related EDTA dependent pseudothrombocytopenia after allogeneic stem cell transplantation. Can it be real? Osmangazi Tıp Dergisi. 2023;45:1011–1014.
MLA
Üsküdar Teke, Hava, ve Eren Gunduz. “Donor-related EDTA dependent pseudothrombocytopenia after allogeneic stem cell transplantation. Can it be real?”. Osmangazi Tıp Dergisi, c. 45, sy 6, Ekim 2023, ss. 1011-4, doi:10.20515/otd.1326098.
Vancouver
1.Hava Üsküdar Teke, Eren Gunduz. Donor-related EDTA dependent pseudothrombocytopenia after allogeneic stem cell transplantation. Can it be real? Osmangazi Tıp Dergisi. 01 Ekim 2023;45(6):1011-4. doi:10.20515/otd.1326098