Effect of GNRH Analogue Treatment on Anthropometric Measurements in Girls Diagnosed with Central Precocious Puberty: One-Year Follow-up Results

Öz

GnRH analogs(GNRHa) are the gold standard treatment for central precocious puberty(CPP).There are studies reporting that body-mass-index(BMI) increases, does not change and can decrease with GnRHa treatment. In this study; It was aimed to evaluate the changes in height, weight,BMI values, waist-circumference, waist-circumference/height ratio in girls with SPP in the first-year of GnRHa treatment. We included 63 female patients who were started on GnRHa treatment with the diagnosis of SPP in our hospital. Height, weight, BMI, waist-circumference were measured before treatment/in the first-year of treatment. Data were analyzed using SPSS25.0software. Results: The mean age was 8.41±0.92years. Mean height, body weight, BMI,predicted adult height(PAH),waist-circumference of the subjects increased statistically significantly in the first year compared to pre-treatment (p<0.001).The first-year waist-circumference percentile values of the cases were found to be higher than before the treatment(p=0.002).Percentage of those with BMI percentile≥85% before treatment and in the first year of treatment, respectively; were 50.8%,58.7%(p=0.180).When the pre-treatment BMI was evaluated in two groups as<85th percentile(n=31) and ≥85th percentile(n=32);There was no significant change in waist-circumference/height ratio, waist/hip circumference ratio, BMI sds, height sds values of both groups in the first year of treatment. Height,weight,BMI,PAH,waist-circumferences, waist-circumference percentiles increased with GnRHa treatment. In subjects with BMI <85th percentile and BMI ≥85th percentile at baseline, no change was observed in BMI sds, height sds values, waist-circumference/height ratio, waist/hip-circumference ratios in the first year of treatment. Further studies are needed to investigate the long-term effects of GnRHa therapy in girls with SPP,with longer duration and in larger groups.

Anahtar Kelimeler

• GNRH Analogue Treatment
• Central Precocious Puberty
• bady mass index
• waist circumference

Santral Puberte Prekoks Tanılı Kızlarda GNRH Analog Tedavisinin Antropometrik Ölçüm Değerlerine etkisi: Bir Yıllık Takip Sonuçları

Öz

GnRH analogları (GNRHa) santral puberte prekoksta(SPP) altın standart tedavi yöntemidir. GnRHa tedavisi ile vücut kitle indeksinde (VKİ) artış olduğunu, değişmediğini ve azalabileceğini bildiren çalışmalar mevcuttur. Bu çalışmada; SPP’li kızlarda GnRHa tedavisinin birinci yılında boy, ağırlık, VKİ değerleri ile bel çevresi, bel çevresi/boy oranındaki değişimin değerlendirmesi amaçlanmıştır. Hastanemizde SPP tanısıyla GnRHa tedavisi başlanan 63 kız olgu dahil edildi. Tedavi öncesi/tedavinin birinci yılında boy, ağırlık, VKİ, bel çevresi ölçümleri yapıldı. Veriler SPSS 25.0 yazılımı kullanılarak analiz edildi. Yaş ortalaması 8,41±0,92 yıl idi. Olguların boy, vücut ağırlığı, VKİ, öngörülen son boy (ÖSB), bel çevreleri ölçüm ortalamaları tedavi öncesine göre birinci yılda istatistiksel olarak çok önemli artış gösterdi (p<0,001). Olguların birinci yıl bel çevresi persentil değerleri tedavi öncesine göre artmış bulundu (p=0,002). VKİ persentili ≥%85 olanların yüzdesi tedavi öncesi ve tedavinin birinci yılında sırasıyla; %50,8 ve %58,7 idi (p=0,180). Tedavi öncesi VKİ <85 persentil(n=31) ve ≥85 persentil(n=32) olarak iki grupta değerlendirildiğinde; tedavinin birinci yılında her iki grubun bel çevresi/boy oranı, bel/kalça çevresi oranı, VKİ sds, boy sds değerlerinde anlamlı değişim görülmedi. GnRHa tedavisiyle boy, vücut ağırlığı, VKİ, ÖSB, bel çevreleri, bel çevresi persentilleri artmıştır. Başlangıçta VKİ<85 persentil ve VKİ ≥85 persentil olgularda, tedavinin birinci yılında VKİ sds, boy sds değerleri ile bel çevresi/boy oranı, bel/kalça çevresi oranları açısından değişiklik gözlenmemiştir. SPP’li kızlarda GnRHa tedavisinin uzun dönem etkilerini daha uzun süreli ve daha büyük gruplarda araştıran ileri çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• GNRH analog tedavisi
• Santral puberte prekoks
• Vücut kitle indeksi
• bel çevresi

Kaynakça

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