Investigation of HSV-1, HSV-2, VZV, EBV, CMV, HHV-6 and HHV-7 Agents in Patients with Pre-diagnosis of Meningitis in a University Hospital

Öz

Meningitis is one of the most important causes of morbidity and mortality in underdeveloped and developing countries. The distribution of meningitis agents varies depending on many factors such as age, season, geographical region and socioeconomic level. The aim of this study was to investigate the distribution of viral meningitis agents in patients with pre-diagnosed meningitis in a university hospital. Between 01.04.2019-01.04.2024, 1588 patients with a prediagnosis of meningitis admitted to various outpatient clinics and wards were included in the study. Cerebrospinal fluid (CSF) obtained from the patients was analyzed for viral agents by polymerase chain reaction (PCR) method. In our study, 17 (1.07%) patients were positive for HHV-7, 13 (0.81%) for EBV, 10 (0.60%) for HHV-6, 8 (0.50%) for HSV-1, 7 (0.44%) for CMV, 6 (0.37%) for VZV and 3 (0.18%) for HSV-2. Knowing the frequency and distribution of meningitis agents that vary according to geographical regions is important for appropriate empirical treatment. With the multiplex PZR method, many pathogens can be investigated simultaneously and the causative agents can be identified. It is very important to have information about the distribution of meningitis agents in our country by increasing the number of molecular epidemiologic studies.

Anahtar Kelimeler

• Viral Meningitis
• Multiplex PCR
• Epidemiology

Bir Üniversite Hastanesinde Menenjit Ön Tanılı Hastalarda HSV-1, HSV-2, VZV, EBV, CMV, HHV-6 ve HHV-7 Etkenlerinin Araştırılması

Öz

Menenjit gelişmemiş ve gelişmekte olan ülkelerdeki en önemli morbidite ve mortalite nedenlerinden biridir. Menenjit etkenlerinin dağılımı yaş, mevsim, coğrafi bölge, sosyoekonomik düzey gibi birçok faktöre bağlı olarak değişmektedir. Bu çalışmanın amacı, bir üniversite hastanesindeki menenjit ön tanılı hastalarda viral menenjit etkenlerinin dağılımının araştırılmasıdır. Çalışmaya 01.04.2019-01.04.2024 tarihleri arasında çeşitli poliklinik ve servislere başvuran menenjit ön tanılı 1588 hasta dahil edildi. Hastalardan alınan beyin omurilik sıvısında (BOS), polimeraz zincir reaksiyonu (PZR) metoduyla viral etkenler araştırıldı. Çalışmamızda 17 (%1,07) hastada HHV-7, 13 (%0,81) hastada EBV, 10 hastada HHV-6 (%0,60), 8 (%0,50) hastada HSV-1, 7 (%0,44) hastada CMV, 6 (%0,37) hastada VZV, 3 (%0,18) hastada HSV-2 pozitif saptandı. Coğrafi bölgelere göre değişiklik gösteren menenjit etkenlerin sıklığını ve dağılımını bilmek uygun ampirik tedavi açısından önem arz etmektedir. Multipleks PZR metoduyla birçok patojen aynı anda araştırılarak etkenler tespit edilebilmektedir. Moleküler epidemiyolojik çalışmaların sayısı arttırılarak ülkemizdeki menenjit etkenlerinin dağılımı hakkında bilgi sahibi olabilmek oldukça önemlidir.

Anahtar Kelimeler

• Viral Menenjit
• Multipleks PCR
• Epidemiyoloji

Kaynakça

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