Evaluating Inflammatory Markers in Sudden Sensorineural Hearing Loss: The Neutrophil-To-Lymphocyte Ratio, The Systemic Immune Inflammation Index, and The Pan Immune Inflammation Value as Prognostic Tools

Yıl 2025, Cilt: 47 Sayı: 3, 386 - 394, 02.05.2025

Sevinç Hepkarşı , Aynur Aliyeva , Gülce Kirazlı , Tayfun Kirazlı

https://doi.org/10.20515/otd.1612452

Cited By: 1

Öz

This research sought to explore the association between sudden sensorineural hearing loss and inflammation by analyzing key inflammatory indicators, such as the neutrophil-to-lymphocyte ratio, the systemic immune inflammation index , and the pan-immune-inflammation value .This retrospective study was conducted at a tertiary medical center's otolaryngology department between 2016 and 2021, involving sudden sensorineural hearing loss patients diagnosed and treated during the specified period. Two hundred sudden sensorineural hearing loss patients and 200 healthy controls were included. Inflammatory markers were calculated from complete blood count data. Audiological evaluations categorized patients based on hearing loss severity. Patients with sudden sensorineural hearing loss demonstrated significantly elevated levels of inflammatory markers compared to the control group: NLR: 3.43 ± 2.99 vs. 2.10 ± 1.28, p < 0.001; SII: 953.72 ± 855.02 vs. 561.74 ± 355.60, p < 0.001; and PIV: 523.84 ± 455.48 vs. 342.48 ± 245.47, p < 0.001. ROC analysis revealed superior diagnostic performance for the systemic immune inflammation index, and the pan-immune-inflammation value, with AUC values of 0.693 and 0.648, respectively, compared to NLR (AUC = 0.692). This study provides novel insights into the relationship between inflammation and sudden sensorineural hearing loss. Elevated neutrophil-to-lymphocyte ratio, the systemic immune inflammation index, and the pan-immune-inflammation value levels in sudden sensorineural hearing loss patients suggest their potential as valuable indicators for understanding the etiology and predicting outcomes of sudden sensorineural hearing loss . The study underscores the need for further research to validate these findings and explore the underlying mechanisms connecting inflammation to sudden sensorineural hearing loss.

Anahtar Kelimeler

Sudden sensorineural hearing loss , Inflammatory markers , SII , PIV , Hearing assessments

Etik Beyan

This study adhered to the Declaration of Helsinki's highest ethical standards and principles. Informed consent was secured from all participants, ensuring anonymity and confidentiality. Izmir Bakıircay University Local Ethics Committee approved (approved number : 24082023/1141/1121; No 1141, Research No 1121 at 24.08.2023) this study. There are no conflicts of interest, and the manuscript respects participant privacy and aligns with relevant ethical guidelines.

Destekleyen Kurum

The authors declared that this study has received no financial support.

Ani Sensörinöral İşitme Kaybında İnflamatuar Belirteçlerin Değerlendirilmesi: Nötrofil-Lenfosit Oranı, Sistemik İmmün İnflamasyon İndeksi ve Pan İmmün İnflamasyon Değerinin Prognostik Rolü

Öz

Bu araştırma, nötrofil lenfosit oranını , sistemik immün-inflamasyon indeksi ve panimmun inflamasyon değeri gibi temel enflamatuar göstergeleri analiz ederek ani işitme kaybı ve enflamasyon arasındaki ilişkiyi araştırmayı amaçlamıştır.Bu retrospektif çalışma, 2016-2021 yılları arasında üçüncü basamak bir tıp merkezinin kulak burun boğaz bölümünde, belirtilen dönemde tanı konulan ve tedavi edilen ani işitme kaybı hastalarını içerecek şekilde yürütülmüştür. 200 ani işitme kaybı tanılı hasta ve 200 sağlıklı kontrol dahil edilmiştir. Enflamatuvar belirteçler tam kan sayımı verilerinden hesaplanmıştır. Odyolojik değerlendirmeler hastaları işitme kaybı şiddetine göre kategorize edilmiştir. Ani işitme kaybı hastalar kontrol grubuna kıyasla anlamlı derecede yüksek enflamatuar belirteç seviyeleri göstermiştir: NLR: 3.43 ± 2.99 vs. 2.10 ± 1.28, p < 0.001; SII: 953.72 ± 855.02 vs. 561.74 ± 355.60, p < 0.001; ve PIV: 523.84 ± 455.48 vs. 342.48 ± 245.47, p < 0.001. ROC analizi, NLR (AUC = 0,692) ile karşılaştırıldığında sırasıyla 0,693 ve 0,648 AUC değerleri ile sistemik immün-inflamasyon indeksi ve panimmun inflamasyon değeri için üstün tanısal performans ortaya koymuştur.Bu çalışma enflamasyon ve ani işitme kaybı arasındaki ilişkiye dair yeni bilgiler sunmaktadır. Ani işitme kaybı hastalarında yüksek nötrofil lenfosit oranını sistemik immün-inflamasyon indeksi ve panimmun inflamasyon değeri düzeyleri, ani işitme kaybının etiyolojisini anlamak ve sonuçlarını öngörmek için değerli göstergeler olarak potansiyellerini göstermektedir. Çalışma, bu bulguları doğrulamak ve enflamasyonu ani işitme kaybına bağlayan altta yatan mekanizmaları keşfetmek için daha fazla araştırma yapılması gerektiğinin altını çizmektedir.

Anahtar Kelimeler

Ani sensörinöral işitme kaybı , Enflamatuar belirteçler , SII , PIV , İşitme değerlendirmeleri

Kaynakça

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