Vitamin D ile İrritabl Bağırsak Sendromu Arasındaki İlişki: Randomize Kontrollü Çalışmalar ve Gözlemsel Araştırmaların Meta-Analizi

Öz

Bu meta-analiz, randomize kontrollü çalışmalardan elde edilen verileri sentezleyerek D vitamini takviyesinin irritabl bağırsak sendromu (IBS) semptomları ve serum 25-hidroksi D vitamini 25(OH)D düzeyleri üzerindeki etkilerini değerlendirmeyi amaçlamıştır. Ek olarak, sağlıklı bireyler ve IBS hastaları arasındaki bazal serum 25(OH)D düzeylerini karşılaştırmayı amaçlamıştır. Çalışma, gözlemsel ve randomize kontrollü çalışmaların (RCT) bir meta-analizidir. PRISMA kılavuzlarına uygun olarak yürütülen çalışmada, 11 çalışma değerlendirilmiş ve IBS-SSS, IBS-QoL ve serum 25(OH)D düzeyleri incelenmiştir. Veriler, heterojenliği değerlendirmek için I² testi kullanılarak analiz edilmiştir. Meta-analiz sonuçları, D vitamini takviyesinin IBS hastalarının yaşam kalitesini iyileştirdiğini göstermiştir (IBS-QoL için ortalama fark [MD]: 6,48, %95 GA: 1,14-11,83, p=0,02). Ancak IBS semptom şiddeti (IBS-SSS) üzerinde anlamlı bir etkisi olmadı (MD: 3.91, %95 GA: -60.99-68.81, p=0.91). Serum 25(OH)D düzeyleri D vitamini takviyesi ile anlamlı şekilde arttı (MD: 17.13, %95 GA: 8.09-26.17, p<0.0002). Serum 25(OH)D düzeyleri sağlıklı bireyler ve IBS hastaları arasında karşılaştırıldığında, IBS hastalarında anlamlı bir azalma gözlendi (standart ortalama fark [SMD]: -10.17, %95 GA: -15.57 ila -4.77, p=0.0005). D vitamini takviyesi IBS hastalarında yaşam kalitesini iyileştirmede ve serum D vitamini düzeylerini artırmada etkili olabilir. Ancak semptom şiddeti üzerindeki etkisini açıklığa kavuşturmak için daha homojen ve geniş ölçekli çalışmalara ihtiyaç vardır. Bu sonuçlar IBS yönetiminde D vitamini takviyesinin rolü hakkında değerli bir bakış açısı sağlar.

Anahtar Kelimeler

• D vitamini
• İrritabl Bağırsak Sendromu
• Meta-analiz
• Randomize Kontrollü Çalışmalar

The Association Between Vitamin D and Irritable Bowel Syndrome: A Meta-Analysis of Randomized Controlled Trials and Observational Studies

Öz

This meta-analysis aimed to evaluate the effects of vitamin D supplementation on irritable bowel syndrome (IBS) symptoms and serum 25-hydroxy vitamin D 25(OH)D levels by synthesizing data from randomized controlled trials. Additionally, it aimed to compare baseline serum 25(OH)D levels between healthy individuals and IBS patients. The study is a meta-analysis of randomized controlled trials (RCTs) and observational studies. In the study conducted in accordance with PRISMA guidelines, 11 studies were evaluated and IBS-SSS, IBS-QoL and serum 25(OH)D levels were examined. Data were analyzed using the I² test to assess heterogeneity. The meta-analysis results showed that vitamin D supplementation improved the quality of life of IBS patients (mean difference [MD] for IBS-QoL: 6.48, 95% CI: 1.14-11.83, p=0.02). However, it had no significant effect on IBS symptom severity (IBS-SSS) (MD: 3.91, 95% CI: -60.99-68.81, p=0.91). Serum 25(OH)D levels were significantly increased by vitamin D supplementation (MD: 17.13, 95% CI: 8.09-26.17, p<0.0002). When serum 25(OH)D levels were compared between healthy individuals and IBS patients, a significant decrease was observed in IBS patients (standard mean difference [SMD]: -10.17, 95% CI: -15.57 to -4.77, p=0.0005). Vitamin D supplementation may be effective in improving quality of life and increasing serum vitamin D levels in IBS patients. However, more homogeneous and large-scale studies are needed to clarify its effect on symptom severity. These results provide a valuable perspective on the role of vitamin D supplementation in the management of IBS.

Anahtar Kelimeler

• Vitamin D
• Irritable Bowel Syndrome
• Meta-analysis
• Randomized Controlled Trials

Kaynakça

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