2005-2024 Yılları Arasında Serebral Palsi’de Botulinum Toksinin Bibliyometrik Analizi

Öz

Bu çalışma, 2005–2024 yılları arasında serebral palside (SP) botulinum toksin A (BoNT‑A) uygulamalarıyla ilgili literatürü değerlendiren kapsamlı bir bibliyometrik analiz sunmaktadır. Web of Science Core Collection veri tabanında yapılan tarama sonucunda 690 yayın (550 araştırma makalesi, 140 derleme) incelenmiştir. Yayın sayısında yıllar içinde genel bir artış gözlenmiş, 2018’de en yüksek üretim gerçekleşmiş, 2020–2021’de geçici bir düşüş yaşanmıştır. Araştırmalara en fazla katkı sağlayan ülkeler ABD, Avustralya ve İtalya olurken, Avustralya en yüksek ortalama atıf oranına ulaşmıştır. En üretken yazar Desloovere K, en çok atıf alan yazar ise Graham HK olarak belirlenmiştir. Anahtar kelime analizinde “cerebral palsy”, “botulinum toxin”, “spasticity” merkezde yer almış; “rehabilitation”, “gait analysis” ve “quality of life” gibi kavramlar ön plana çıkmıştır. Son yıllarda “ultrasound” ve “electromyography” gibi teknolojik kavramların kullanımı artmıştır. Ayrıca “sialorrhea” tedavisine yönelik intraglandüler BoNT‑A uygulamaları vurgulanmıştır. Çalışmada, üst ekstremitede BoNT‑A’nın fonksiyonel kazanımlar için rehabilitasyonla birlikte uygulanmasının önerildiği belirtilmiştir. Literatürde uzun dönem etkinlik verilerinin sınırlı olduğu ve çok merkezli, prospektif çalışmalara ihtiyaç duyulduğu vurgulanmıştır.

Anahtar Kelimeler

• bibliyometrik analiz
• botulinum toksin
• serebral palsi
• spastisite

A Bibliometric Analysis of Botulinum Toxin in Cerebral Palsy from 2005 to 2024

Öz

This study presents a comprehensive bibliometric analysis of the literature on botulinum toxin A (BoNT‑A) applications in cerebral palsy (CP) between 2005 and 2024. A search conducted in the Web of Science Core Collection identified 690 publications (550 original research articles and 140 reviews). An overall increase in publication output was observed over the years, peaking in 2018, with a temporary decline noted in 2020–2021. The United States, Australia, and Italy were the leading contributors, with Australia achieving the highest average citation rate. Desloovere K was identified as the most productive author, while Graham HK received the highest number of citations. Keyword analysis revealed that “cerebral palsy,” “botulinum toxin,” and “spasticity” were central themes, while concepts such as “rehabilitation,” “gait analysis,” and “quality of life” also stood out. In recent years, the use of technological terms such as “ultrasound” and “electromyography” has increased. In addition, intraglandular BoNT‑A applications for the treatment of “sialorrhea” have been highlighted. The study also noted that BoNT‑A in the upper limb is recommended to be combined with rehabilitation in order to achieve functional gains. The literature emphasizes that data on long‑term efficacy remain limited and that there is a need for multicenter, prospective studies.

Anahtar Kelimeler

• bibliometric analysis
• botulinum toxin
• cerebral palsy
• spasticty

Kaynakça

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