Lökomoid Reaksiyon ve Konglemere Lenfadenopatiler İle Prezente Olan Granülositik Sarkom Olgusu

Year 2018, , 70 - 74, 12.03.2018

Hava Üsküdar Teke , Hamide Eda Tatlıpınar Neslihan Andıç Eren Gündüz , Funda Canaz , Olga Meltem Akay

https://doi.org/10.20515/otd.349655

Abstract

Granülositik
sarkom, myeloid seri progenitör hücrelerini içeren ekstrameduller alanlarda yer
alan tümöral bir kitledir. Genellikle kemik, periost, yumuşak dokuda lokalize
olurlar. Granülositik sarkom, çok yaygın olarak, akut myeloid löseminin klinik
bir başlangıç bulgusu olarak kendini gösterebilir. 42 yaşında olan ve boğaz
ağrısı nedenli kliniğimize başvuran olgumuzun fizik muayenesinde tonsiller
hipertrofik, hepatosplenomegali ve multipl konglemere özellikte
lenfadenopatileri mevcuttu. Laboratuvar incelemesinde, hemoglobin 7.2 gr/dl,
lökosit 144x109/L platelet 36x109/L saptandı. Periferik yayma ve kemik iliği
aspirasyon bulguları ile akut veya kronik myeloid lösemi düşünülmeyen hastaya
lenfoma ön tanısı ile eksizyonel lenf nodu biyopisi yapıldı ve biyopsi sonucu
granulositik sarkom ile uyumlu saptanarak 7+3 remisyon-indüksiyon kemoterapisi
başlandı. Hasta progresyon ve sepsis nedenle ex oldu. Sonuç olarak; lökomoid
reaksiyonla gelen ve patolojik lenfadenopatileri olan hastalarda tabloya
granülositik sarkomun eşlik edebileceği düşünülmeli ve doku tanısı ile ön tanı
desteklenmelidir.

Keywords

Lenfadenopati, granulositik sarkom

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