Tübülointerstisyel Nefrit ve Üveit (TİNU) Sendromu: Literatür Eşliğinde Bir Olgu

Öz

Tubulointerstisyel nefrit ve üveit (TINU) sendromu, akut tubulointerstisyel nefrit ve üveit birlikteliği ile karakterizedir. Bu sendrom akut tubulointerstisyel nefritin nadir bir nedeni olup diğer sebeplerin dışlanmasıyla tanı alır. Bu olgu sunumunda böbrek tutulumundan önce üveit gelişen ve nüks nedeniyle TINU sendromu tanısı konan 56 yaşında bir kadın hasta sunuldu. Ayrıca literatür ışığında oküler tutulum tipini kısaca gözden geçirdik.

Anahtar Kelimeler

• Akut tubulointerstisyel nefrit,tubulointerstisyel nefrit ve üveit (TINU) sendromu,uveit

Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome: A Case Report and Review of Literatüre

Öz

Tubulointerstitial nephritis and uveitis (TINU) syndrome is characterized by the association of acute tubulointerstitial nephritis and uveitis. This syndrome is a rare cause of acute tubulointerstitial nephritis and is a diagnosis of exclusion.  In this case report, we presented a 56-year-old female patient, who developed uveitis before kidney involvement and was diagnosed with TINU syndrome due to recurrences. We also briefly reviewed the type of ocular involvement in light of literature. 

Anahtar Kelimeler

• Acute tubulointerstitial nephritis,tubulointerstitial nephritis and uveitis (TINU) syndrome,uveitis

Kaynakça

1. Dobrin RS, Vernier RL, Fish AJ. Acute eosinophilic interstitial nephritis and renal failure with bone marrow lymph node granulomas and anterior uveitis. Am J Med 1975; 59: 325-33.
2. Vanhaesebrouck P, Carton D, De Bel C, Praet M, Proesmans W. Acute tubulo-interstitial nephritis and uveitis syndrome (TINU syndrome). Nephron 1985; 40:418-22
3. Gafter U, Kalechman Y, Zevin D, Korzets A, Livni E,Klein T, Sredni B, Levi J. Tubulointerstitial nephritis and uveitis: association with suppressed cellular immunity. Nephrol Dial Transplant 1993; 8: 821-6.
4. Wakaki H, Sakamoto H, Awazu M. Tubulointerstitial nephritis and uveitis syndrome with autoantibody directed to renal tubular cells. Pediatrics 2001; 107: 1443-6.
5. Tan Y, Yu F, Zhao M-H. Autoimmunity of patients with TINU syndrome. Hong Kong J Nephrol 2011; 13:46–50.
6. Levinson RD. Tubulointerstitial nephritis and uveitis syndrome. Int Ophthalmol Clin 2008;48:51-9
7. Mandeville, John TH, Ralph D. Levinson, and Gary N. Holland. "The tubulointerstitial nephritis and uveitis syndrome." Survey of ophthalmology 46.3 (2001): 195- 208.