Atypically Located Basal Cell Carcinoma: Three Case Reports

Öz

Bazal hücreli karsinom (BHK)  insanda en sık görülen malign tümördür. Deride herhangi bir yerde görülebilmekle birlikte, %80’den fazlası baş ve boyun gibi güneşe maruz kalan alanlarda ortaya çıkmaktadır. Gelişiminde kronik güneş ışığına maruziyet, ana etyolojik faktör olarak düşünülmektedir. Biz burada; bel bölgesinde, femur lateral bölgede ve perine bölgesinde olağan dışı yerleşim gösteren BHK’lı üç olgu sunduk. Hastaların öykülerinde bu bölgelerde BHK gelişimi açısından etyolojik herhangi bir predizpozan faktöre rastlanmamıştır. BHK’da metastaz riski çok nadir olmasına rağmen, tümör lokal agresif seyredebilir ve doku destrüksiyonuna neden olabilir. Bu nedenle; atipik lokalizyonlarda  yerleşim gösteren lezyonlarda da BHK akla gelmesini vurgulamak amacıyla vakalarımız literatür eşliğinde tartışılarak sunulmaktadır.

Anahtar Kelimeler

• Basal cell carcinoma,clinical variants,atypical involvement

Atypically Located Basal Cell Carcinoma: Three Case Reports

Öz

Basal cell carcinoma (BCC) is the most common malignant tumor in humans. It can be seen anywhere in the skin, although more than 80% occurs in areas exposed to the sun, such as the head and neck. Chronic exposure to sunlight is thought to be the main etiological factor. Although the risk of metastasis in BCC is very low, the tumor may be locally aggressive and cause tissue destruction. We present three cases of BCC in atypical locations, the waist region, the lateral femoral region, and the perineal region. No predisposing factor in terms of etiology of BCC was encountered in these patients’ histories. We are presenting our cases, together with a discussion of the current literature, to emphasize that BCC should be considered even in atypically located lesions.

Anahtar Kelimeler

• Basal cell carcinoma,clinical variants,atypical involvement

Kaynakça

1. Referans1. Mohan SV, Chang AL. Advanced Basal Cell Carcinoma: Epidemiology and Therapeutic Innovations. Curr Dermatol Rep. 2014;3(1):40-5
2. Referans2. Chang JM, Gao XM. Clinical and histopathological characteristics of basal cell carcinoma in Chinese patients. Chin Med J (Engl). 2013;126(2):211-4.
3. Referans3. Aldana PC, Yfantis HG, John PR. Perianal Basal Cell Carcinoma Successfully Managed with Excisional Biopsy. Case Rep Dermatol Med. 2019;2019: 6268354.
4. Referans4. Cameron MC, Lee E, Hibler BP, Barker CA, Mori S, Cordova M, Nehal KS, Rossi AM. Basal cell carcinoma: Epidemiology; pathophysiology; clinical and histological subtypes; and disease associations. J. Am. Acad. Dermatol. 2019 ; 80(2):303-17.
5. Referans5. Dourmishev LA, Rusinova D, Botev I. Clinical variants, stages, and management of basal cell carcinoma. Indian Dermatol Online J. 2013; 4(1):12-7.
6. Referans6. Schlessinger DI, Iyengar S, Yanes AF, Lazaroff JM, Godinez-Puig V, Chen BR. Development of a core outcome set for clinical trials in basal cell carcinoma: study protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey. Trials. 2017;18(1):490.
7. Referans7. Cohen PR. Basal cell carcinoma of the axilla: review of the world literature. Am J Clin Dermatol. 2014;15(2):95-100.
8. Referans8. Kim JYS, Kozlow JH, Mittal B, Moyer J, Olencki T, Rodgers P. Guidelines of care for the management of basal cell carcinoma. J Am Acad Dermatol. 2018;78(3):540-59.

9. Referans9. Pranteda G, Grimaldi M, Lombardi M, Pranteda G, Arcese A, Cortesi G, Muscianese M, Bottoni U.Basal cell carcinoma: differences according to anatomic location and clinical-pathological subtypes.G Ital Dermatol Venereol. 2014 Aug;149(4):423-6.
10. Referans10. Narala S, Cohen PR.Basal Cell Carcinoma of the Umbilicus: A Comprehensive Literature Review.Cureus. 2016 ;8(9):770.
11. Referans11. Carr AV, Feller E, Zakka FR, Griffith RC, Schechter S. A Case Report of Basal Cell Carcinoma in a Non-Sun-Exposed Area: A Rare Presentation Mimicking Recurrent Perianal Abscess.Case Rep Surg. 2018;2018:9021289.