TEK BEYİN METASTAZLI HASTALARDA TÜM BEYİN + SİMÜLTANE ENTEGRE BOOST RADYOTERAPİSİ

Year 2016, Volume: 38 Issue: 3, 40 - 45, 06.06.2016

Alaattin Özen Suzan Şaylısoy Evrim Metcalfe Durmuş Etiz

Abstract

ÖZET: Bu çalışmanın amacı tek beyin metastazına sahip küçük
hücreli dışı akciğer kanseri (KHDAK) tanılı hastalarda yoğunluk ayarlı
radyoterapi (YART) planlama yöntemi ile tüm beyin radyoterapisi + simültane
entegre boost (TBRT + SEB) tekniğini
kullanarak hedef dokuda doz yükseltilmesinin erken dönem sonuçlarının
değerlendirmesidir. Tek beyin metastazına sahip ve TBRT + SEB tedavisi
uygulanan KHDAK tanılı hastalar geriye dönük olarak değerlendirildi. Temmuz
2015 - Ocak 2016 arasında toplamda 11 hastaya ulaşıldı. Hasta ve tümöre ait
özellikler, demografik veriler, tedavi bilgisi ve özellikleri incelendi. Tedavi
süresince tüm hastalara antiödem tedavi rutin başlandı. Hastalarda grade III-IV
toksisite gözlemlenmedi. Hastaların radyoterapiden 1 ay sonra çekilen beyin MR
görüntüleri değerlendirildi ve tedavi öncesi beyin MR görüntüleri ile
karşılaştırılarak 7 (%63) hastada tam yanıt, 4 (%37) hastada ise kısmi yanıt
elde tespit edildi. Sonuç olarak TBRT + SEB tekniği radyocerrahi uygulamasına
göre teknik olarak daha basit uygulanabilir, oldukça etkin ve hastalar
tarafından tolere edilebilir bir yöntemdir.

ANAHTAR KELİMELER: tüm beyin
radyoterapisi (TBRT), simültane entegre boost
(SEB), akciğer kanseri, tek beyin metastazı

WHOLE BRAIN RADIOTHERAPY (WBRT) WITH
SIMULTANEOUS INTEGRATED BOOST (SIB) IN PATIENTS WITH SINGLE BRAIN METASTASIS

ABSTRACT: The aim of
this study is to evaluate the early phase treatment results of dose escalation
using by whole brain radiotherapy (WBRT) with simultaneous integrated boost
(SIB) in non-small cell lung cancer patients with single brain metastasis. We
evaluated retrospectively non-small cell lung cancer patients treated with WBRT
+ SIB. We achieved the data of 11 non-small cell lung cancer patients who were
treated between July 2015 and January 2016. Patient and tumor characteristics,
demographic data and treatment features have been evaluated. We prescribed
antiedema treatment to all patients in whole duration of radiotherapy. We did
not observe any grade III-IV toxicity. Cranial MRI images in the first month
after radiotherapy has been evaluated and compared with preradiotherapy images.
Complete response was identified in 7 (63%) patients and partial response was
identified in 4 (37%) patients. In conclusion, WBRT + SIB technique is easier
to apply when compared with radiosurgery, an effective and tolerable method for
patients.

KEYWORDS: Whole
brain radiotherapy (WBRT), simultaneous integrated boost (SIB), lung cancer,
single brain metastasis

Keywords

Tüm beyin radyoterapisi (TBRT), Simültane entegre boost (SEB), akciğer kanseri

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