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Güneydoğu Bölgesinde Erişkinlerde D Vitamini Eksikliği/Vitamin D Deficiency In Adult Residents of Southern Turkey

Yıl 2017, Cilt: 39 Sayı: 1, 13 - 20, 07.01.2017
https://doi.org/10.20515/otd.52389

Öz

Özet: D
vitamini eksikliği gelişmekte olan ülkelerde daha belirgin olmak üzere tüm
dünyada yaygın bir sağlık sorunudur. D vitamini pek çok fizyolojik süreçte
görev alır. Türkiye’de güneydoğu bölgesinde sıcak ve kuru bir iklime sahip
Diyarbakır şehrinde yaşayan kişilerde kış aylarında D vitamini eksikliğini
incelemeyi amaçladık. 215 kadın ve 49 erkek katılımcının geçmiş tıbbi kayıtları
değerlendirildi. Serum 25(OH)D3 düzeyleri elektrokemiluminisans (ECLIA) yöntemi
(Elecsys assay on Roche Modular E170 analyzer, Roche Diagnostics, Germany) ile
ölçüldü. Katılımcıların ortalama yaşı 41 (standart sapma 15 yaş) idi. Kesim
değeri 20 ng/ml alındığında, D vitamini eksikliği oranı %94 bulundu. D vitamini
düzeyi kadınlarda erkeklere göre daha düşük belirlendi (9.6±5.2 ve 14.6±5.4
ng/ml, p=0.0001). Örtünme, vücut kitle indeksi ve gelir düzeyine göre D
vitamini düzeyleri farklı değildi. Ancak sedanter olanlarda D vitamini düzeyi
aktif kişilere göre daha düşük idi (9.6±5.2 ve 13.3±5.7 ng/ml, p=0.0001). D
vitamini eksikliği endemik bir sağlık sorunu olmakla birlikte kadın cinsiyet,
sedanter yaşam ve düşük gelir grupları riskli gruplardır.



Anahtar
Kelimeler:
D
vitamini eksikliği, 25-hidroksi D vitamini, iklim, örtünme


Abstract: Vitamin
D insufficiency is a widespread public health problem in the world especially
in developing countries. Vitamin D operates in various physiological processes.
We aimed to evaluate deficiency of vitamin D in winter in residents of
Diyarbakır city, which is located at southern region of Turkey.Past medical
records of 215 female and 49 male subjects were retrospectively evaluated for
vitamin D insufficiency. Serum concentrations of 25(OH)D3 was measured by
electrochemiluminescence immunassay (ECLIA) method (Elecsys assay on Roche
Modular E170 analyzer, Roche Diagnostics, Germany). The mean age of all subjects
was 41.0 years (SD 15.0). The frequency of vitamin D deficiency using cut-off
point below 20 ng/ml was 94%. Vitamin D level was lower in women compared to
men (9.6±5.2 vs 14.6±5.4 ng/ml, p=0.0001). Vitamin D level was not
significantly different regarding veiling, BMI, and monthly income. However,
the subjects leading a sedentary lifestyle had significantly lower vitamin D
level compared to the active ones (9.6±5.2 vs 13.3±5.7 ng/ml, p=0.0001).
Despite the fact that vitamin D is a worldwide endemic health issue, female
gender, sedentary lifestyle, and low income constitute risky groups.



Keywords: vitamin D deficiency, 25-hydroxy vitamin
D, climate, veiling

Kaynakça

  • 1. Binkley, N., Ramamurthy, R., & Krueger, D. (2012). Low vitamin D status: definition, prevalence, consequences, and correction. Rheumatic Disease Clinics of North America, 38(1), 45-59.
  • 2. Holick, M. F., & Chen, T. C. (2008). Vitamin D deficiency: a worldwide problem with health consequences. The American journal of clinical nutrition, 87(4), 1080S-1086S.
  • 3. Stechschulte, S. A., Kirsner, R. S., & Federman, D. G. (2009). Vitamin D: bone and beyond, rationale and recommendations for supplementation. The American journal of medicine, 122(9), 793-802.
  • 4. Hollis, B. W. (2010). Assessment and interpretation of circulating 25-hydroxyvitamin D and 1, 25-dihydroxyvitamin D in the clinical environment.Endocrinology and metabolism clinics of North America, 39(2), 271-286.
  • 5. Bischoff-Ferrari, H. A., Giovannucci, E., Willett, W. C., Dietrich, T., & Dawson-Hughes, B. (2006). Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. The American journal of clinical nutrition, 84(1), 18-28.
  • 6. Leino, A., Turpeinen, U., & Koskinen, P. (2008). Automated measurement of 25-OH vitamin D3 on the Roche Modular E170 analyzer. Clinical chemistry, 54(12), 2059-2062.
  • 7. Van der Meer, I. M., Middelkoop, B. J. C., Boeke, A. J. P., & Lips, P. T. A. M. (2011). Prevalence of vitamin D deficiency among Turkish, Moroccan, Indian and sub-Sahara African populations in Europe and their countries of origin: an overview. Osteoporosis International, 22(4), 1009-1021.
  • 8. Moreno-Reyes, R., Carpentier, Y. A., Boelaert, M., El Moumni, K., Dufourny, G., Bazelmans, C., ... & Goldman, S. (2009). Vitamin D deficiency and hyperparathyroidism in relation to ethnicity: a cross-sectional survey in healthy adults. European journal of nutrition, 48(1), 31-37.
  • 9. Erkal, M. Z., Wilde, J., Bilgin, Y., Akinci, A., Demir, E., Bödeker, R. H., ... & Holick, M. F. (2006). High prevalence of vitamin D deficiency, secondary hyperparathyroidism and generalized bone pain in Turkish immigrants in Germany: identification of risk factors. Osteoporosis international, 17(8), 1133-1140.
  • 10. van der Meer, I. M., Karamali, N. S., Boeke, A. J., Lips, P., Middelkoop, B. J., Verhoeven, I., & Wuister, J. D. (2006). High prevalence of vitamin.
  • 11. Holvik, K., Meyer, H. E., Haug, E., & Brunvand, L. (2005). Prevalence and predictors of vitamin D deficiency in five immigrant groups living in Oslo, Norway: the Oslo Immigrant Health Study. European journal of clinical nutrition,59(1), 57-63.
  • 12. Satman, I., Ozbey, N. C., Boztepe, H., Kalaca, S., Omer, B., Tanakol, R., ... & Alagol, F. (2012). Prevalence and of vitamin D deficiency and associated factors in Turkey. Diabetes, 1(9.0), 6-9.
  • 13. Atli, T., Gullu, S., Uysal, A. R., & Erdogan, G. (2005). The prevalence of vitamin D deficiency and effects of ultraviolet light on vitamin D levels in elderly Turkish population. Archives of gerontology and geriatrics, 40(1), 53-60.
  • 14. Guzel, R., Kozanoglu, E., Guler-Uysal, F., Soyupak, S., & Sarpel, T. (2001). Vitamin D status and bone mineral density of veiled and unveiled Turkish women. Journal of women's health & gender-based medicine, 10(8), 765-770.
  • 15. Basaran, S., Guzel, R., Coskun-Benlidayi, I., & Guler-Uysal, F. (2007). Vitamin D status: effects on quality of life in osteoporosis among Turkish women. Quality of Life Research, 16(9), 1491-1499.
  • 16. Güler, T., Sivas, F., Başkan, B. M., Günesen, Ö., Alemdaroğlu, E., & Özoran, K. (2007). The effect of outfitting style on bone mineral density. Rheumatology international, 27(8), 723-727.
  • 17. Kokino S, Pekindil Y, Hakguder A, Yildiz M. (2004). Postmenopozal kadınlarda kemik mineral yoğunluğu ile D vitamini ve diğer laboratuvar değerlerin karşılaştırılması. Osteoporoz Dunyasindan, 10(2), 70-73.
  • 18. Yener, M., & Akkuş, S. (2006). Fibromyalji'li hastalarda serum 25-hidroksi D vitamini ve parathormon düzeyleri. SDÜ Tıp Fakültesi Dergisi, 13(2).
  • 19. Alagöl, F., Shihadeh, Y., Boztepe, H., Tanakol, R., Yarman, S., Azizlerli, H., & Sandalci, Ö. (2000). Sunlight exposure and vitamin D deficiency in Turkish women. Journal of endocrinological investigation, 23(3), 173-177.
  • 20. Toker A, Cigerli S, Eren N, Turgay F, Kuran B. (2003). Correlation between the bone mineral density and the circulating bone metabolism markers in NIDDM male patients. SEH Tip Bulteni; 37(4), 52-60.
  • 21. Buyukuslu, N., Esin, K., Hizli, H., Sunal, N., Yigit, P., & Garipagaoglu, M. (2014). Clothing preference affects vitamin D status of young women. Nutrition Research, 34(8), 688-693.
  • 22. Baroncelli, G. I., Bereket, A., El Kholy, M., Audi, L., Cesur, Y., Ozkan, B., ... & Hochberg, Z. E. (2008). Rickets in the Middle East: role of environment and genetic predisposition. The Journal of Clinical Endocrinology & Metabolism, 93(5), 1743-1750.
  • 23. Cinar, N., Harmanci, A., Yildiz, B. O., & Bayraktar, M. (2014). Vitamin D status and seasonal changes in plasma concentrations of 25-hydroxyvitamin D in office workers in Ankara, Turkey. European journal of internal medicine, 25(2), 197-201.
  • 24. Cigerli, O., Parildar, H., Unal, A. D., Tarcin, O., Erdal, R., & Demirag, N. G. (2013). Vitamin D deficiency is a problem for adult out-patients? A university hospital sample in Istanbul, Turkey. Public health nutrition, 16(07), 1306-1313.
  • 25. Hekimsoy, Z., Dinç, G., Kafesçiler, S., Onur, E., Güvenç, Y., Pala, T., ... & Özmen, B. (2010). Vitamin D status among adults in the Aegean region of Turkey. BMC Public Health, 10(1), 782.
  • 26. Bolland, M. J., Chiu, W. W., Davidson, J. S., Grey, A., Bacon, C., Gamble, G. D., & Reid, I. R. (2008). The effects of seasonal variation of 25-hydroxyvitamin D on diagnosis of vitamin D insufficiency. The New Zealand Medical Journal (Online), 121(1286).
  • 27. Levis, S., Gomez, A., Jimenez, C., Veras, L., Ma, F., Lai, S., ... & Roos, B. A. (2005). Vitamin D deficiency and seasonal variation in an adult South Florida population. The Journal of Clinical Endocrinology & Metabolism, 90(3), 1557-1562.
  • 28. Binkley, N., Krueger, D., Gemar, D., & Drezner, M. K. (2008). Correlation among 25-hydroxy-vitamin D assays. The Journal of Clinical Endocrinology & Metabolism, 93(5), 1804-1808.
  • 29. Hunter, D., De Lange, M., Snieder, H., MacGregor, A. J., Swaminathan, R., Thakker, R. V., & Spector, T. D. (2001). Genetic contribution to bone metabolism, calcium excretion, and vitamin D and parathyroid hormone regulation. Journal of Bone and Mineral Research, 16(2), 371-378.
  • 30. Glass, D., Lens, M., Swaminathan, R., Spector, T. D., & Bataille, V. (2009). Pigmentation and vitamin D metabolism in Caucasians: low vitamin D serum levels in fair skin types in the UK. PLoS One, 4(8), e6477.
  • 31. Ramos‐Lopez, E., Brück, P., Jansen, T., Herwig, J., & Badenhoop, K. (2007). CYP2R1 (vitamin D 25‐hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Diabetes/metabolism research and reviews, 23(8), 631-636.
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm ORİJİNAL MAKALELER / ORIGINAL ARTICLES
Yazarlar

Bengür Taşkıran

Güven Barış Cansu Bu kişi benim

Yayımlanma Tarihi 7 Ocak 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 39 Sayı: 1

Kaynak Göster

Vancouver Taşkıran B, Cansu GB. Güneydoğu Bölgesinde Erişkinlerde D Vitamini Eksikliği/Vitamin D Deficiency In Adult Residents of Southern Turkey. Osmangazi Tıp Dergisi. 2017;39(1):13-20.


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