Çocuklardaki Alerjik Rinit, Astım ve Atopik Dermatitle Adipokinlerin İlişkisi

Year 2018, Volume: 40 Issue: 2, 1 - 5, 27.02.2018

Fatma Aydın Hülya Anıl Abdülkadir Koçak Koray Harmancı Gürkan Bozan

https://doi.org/10.20515/otd.323807

Abstract

Adipokinler ile
alerjik hastalıklar arasında giderek artan oranda bir ilişki saptanmasına
rağmen, altta yatan mekanizmalar hakkında elimizde çok az veri bulunmaktadır.
Bu çalışmada plazma leptin ve adiponektin konsantrasyonlarının astım ve diğer
alerjik hastalıklarla olan ilişkisinin incelenmesi amaçlanmıştır. Astım,
alerjik rinit ve atopik dermatitli 71 hasta ve 54 sağlam çocuk çalışmaya
alınmıştır. Vücut kitle indeksleri, solunum fonksiyon testleri ve deri prick
testleri yapılan hastalardan total eozinofil sayısı, total serum Immunglobulin
E, spesifik Immunglobulin E (phadiotop), leptin ve adiponektin düzeyleri için
kan alınmıştır. Plazma leptin konsantrasyonu ile vücut kitle indeksi arasında
pozitif korelasyon saptanırken, plazma adiponektin düzeyleri ile vücut kitle
indeksi arasında negatif korelasyon saptanmıştır. Atopik dermatitli çocuklar
diğer hasta ve sağlıklı çocuklara göre daha yüksek leptin düzeylerine
sahiplerdi. Fakat adiponektin düzeyleri açısından böyle bir yüksekliğe
rastlanmadı. Serum leptin düzeyleri ile vücut kitle indeksi arasında güçlü
bir  pozitif korelasyon saptandı. Bu
sonuçlara göre serum leptin düzeyleri çocuklarda atopik dermatit riskiyle
ilişkilendirilebilirken, adiponektin düzeyleriyle böyle bir ilişki
saptanmamıştır.

Keywords

Astım, leptin, adiponektin, alerjik rinit

Associatıons of Adipokines with Allergic Rhinitis, Asthma and Atopic Dermatitis in Children

Abstract

There
is growing evidence for an association between adipokines and allergic
disorders but little is known about the underlying mechanisms. We hypothesized
that high plasma leptin and adiponectin concentrations might be related to
asthma and the other allergic diseases. We studied 71 children with allergic
diseases (asthma, allergic rhinitis, atopic dermatitis) and 54 healthy
children. Body mass indexes, pulmonary function tests and skin prick test were
performed.  Total eosinophil count, total
serum immunoglobulin E (IgE), serum spesific IgE (phadiotop)  leptin and adiponectin were measured in all
subjects. There was a strong positive correlation for plasma leptin
concentrations with body mass index BMI, Adiponectin, however, was negatively
correlated with BMI. Children with atopic dermatitis had higher leptin levels
compared with the other allergic diseases and control groups, but adiponectin
did not show any difference among these three groups. Serum leptin levels are
strongly correlated with measures of 
BMI. These results suggest that leptin may contribute to increased
atopic dermatitis risk in children. but no correlation was found with plasma
adiponectin concentrations

Keywords

Asthma, leptin, adiponectin, allergic rhinitis

References

• 1.Spergel JM (2005). Atopic march: link to upper airways. Curr Opin Allergy Clin Immunol 5:17-21
• 2. Kalyoncu AF,Demir AU,Özçakar B,Bozkurt B,Artvinli M (2001)Asthma and allergy in Turkish university students:Two cross-sectional surveys 5 years apart .Allergol Immunopathol 29:264-71
• 3.Viinanen A, Munhbayarlah S,Zevgee T,Narantsetseg L, Naidansuren TS,Koskenvuo M,Helenius H, Terho EO (2005). Prevalence os asthma, allergic rhinoconjunctivitis and allergic sensitization in Mongolia.Allergy 60:1370-7
• 4.Global Initiative for Asthma(GINA) (2014): Global Strategy for Asthma Management and Prevention.
• 5. Ford ES (2005). The epidemiology of obesity and asthma. J Allergy Clin Immunol 115:897–909.
• 6. Shore SA (2008). Obesity and asthma: possible mechanisms. J Allergy Clin Immunol 121:1087–1093.
• 7. Litonjua AA, Gold DR (2008) Asthma and obesity: common early-life influences in the inception of disease. J Allergy Clin Immunol. 121:1075–1084.
• 8. Van Veen IH, Ten Brinke A, Sterk PJ, Rabe KF, Bel EH (2008). Airway inflammationin obese and nonobese patients with difficult-to-treat asthma. Allergy 63:570–574. 9. Husemoen LL, Glumer C, Lau C, Pisinger C, Morch LS, Linneberg A (2008). Association of obesity and insulin resistance with asthma and aeroallergen sensitization. Allergy. 63:575–582.
• 10. Marcos L, Arnedo Pena A, Busquets-Monge R, Morales Sua´rez-Varela M, Garcı´a de Andoin N, Batlles- Garrido J et al (2008). How the presence ofrhinoconjunctivitis and the severity of asthma modify the relationship betweenobesity and asthma in children 6–7 years old. Clin Exp Allergy 38:1174-1178
• 11. Beuther DA, Weiss ST, Sutherland ER (2006). Obesity and asthma. Am J Respir Crit Care Med 174:112-9.
• 12. Sutherland ER, Goleva E, Strand M, Beuther DA, Leung DY (2008). Body mass and glucocorticoid response in asthma. Am J Respir Crit Care Med. 178:682-7.
• 13. Rosenbaum M, Nicolson M, Hirsch J, Heymsfield SB, Gallagher D, Chu F, et al (1996) Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 81:3424-7.
• 14. Meyer K, Rajesk K, Gordon R, Herman E, Agustin C, Peter J, Carolyn M, Cynthia M, Elizabeth C, Suzanna F, Stanley J, Christine A, Wayne JM (2010). Asthma control, adiposity, and adipokines among iner-city adolescents. Asthma & Immunology. 584-92.
• 15. Jartti T, Saarikoski L, Jartti L, Lisinen I, Jula A, Huupponen R, Viikari J, Raitakari OT. Obesity, adipokines and asthma (2009). Allergy 64:770–777
• 16. Kim KW, Shin YH, Lee KE, Kim ES, Sohn MH, Kim KE. Relationshipbetween adipokines and manifestations of childhood asthma. PediatrAllergy Immunol 19: 535–540, 2008
• 17. Nagel G, Koenig W, Rapp K, Wabitsch M, Zoellner I, Weiland SK (2009). Associations of adipokines with asthma, rhinoconjunctivitis, and eczemain German school children. Pediatr Allergy Immunol 20: 81–88, 2009
• 18. Kai-Chung Hsueh,Ying-Ju Lin, Hsiao Chuan Lin, Ching-Yuang Lin (2010). Serum leptin and adiponectin leves correlate with severity of allergic rhinitis. Pediatric Allergy And Immunology 21:155-159
• 19. Nagy TR, Gower BA, Trowbridge CA, Dezenberg C, Shewchuk RM, Goran MI (1997). Effects of gender ethnicity, body composition, and fat distribution on serum leptin concentrations in children. J Clin Endocrinol Metab. 82: 2148-52
• 20. Guler N, Kirerleri E, Ones U, Tamay Z, Salmayenli N, Darendeliler F (2004). Leptin: does it have any role in childhood asthma? J Allergy ClinImmunol 114: 254–259, 2004.
• 21. Mai XM, Bottcher MF, Leijon I (2004). Leptin and asthma in overweight children at 12 years of age. Pediatr Allergy Immunol 15: 523-30
• 22. Sood A, Cui X, Qualls C, Beckett WS, Gross MD, Steffes MW, Smith LJ, Jacobs DR Jr (2008). Association between asthma and serum adiponectinconcentration in women. Thorax 63: 877–882.
• 23.Ajuwon KM, Spurlock ME (2005). Adiponectin inhibits LPS-induced NF-kappa_B activation and IL-6 production and increases PPAR_2 expression in adipocytes. Am J Physiol Regul Integr Comp Physiol 288: 1220– 1225.
• 24. D.Rothenbacher, M.Weyerman, G.Fantuzzi, H Brenner (2007)Adipokines in cord blood and risk of wheezing disorders within the first two years of life. Clnical and Experimental Allergy 37,1143-49
• 25. Shore SA, Terry RD, Flynt L, Xu A, Hug C (2006) Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 118: 389–95.
• 26. Herbert Tilg and Alexander R (2006). Moschen Nature Reviews Immunology 6, 772-783.
• 27.Saijo S, Nagata K, Nakano Y, Tobe T, Kobyashi Y (2005). Inhibition by adiponectin ofIL-8 production by human macrophages upon coculturing with late apoptoticcells. Biochem Biophys Res Commun. 334: 1180-3.
• 28. Yamaguchi N (2005). Adiponectin inhibits Toll-like receptor family-induced signaling. FEBS Lett 579: 6821–6.
• 29.Blum WF, Englaro P, Hanitsch S, Juul A, Hertel NT, Müller J (1997). Plasma leptin levels in healty children and adolescent: dependence on body mass index, body fat mass, gender, pubertal stage and testosterone. J.Clin Endocrinol Metab 82:2904-10