Çocuklardaki Alerjik Rinit, Astım ve Atopik Dermatitle Adipokinlerin İlişkisi

Yıl 2018, Cilt: 40 Sayı: 2, 1 - 5, 27.02.2018

Fatma Aydın Hülya Anıl , Abdülkadir Koçak , Koray Harmancı , Gürkan Bozan

https://doi.org/10.20515/otd.323807

Öz

Adipokinler ile
alerjik hastalıklar arasında giderek artan oranda bir ilişki saptanmasına
rağmen, altta yatan mekanizmalar hakkında elimizde çok az veri bulunmaktadır.
Bu çalışmada plazma leptin ve adiponektin konsantrasyonlarının astım ve diğer
alerjik hastalıklarla olan ilişkisinin incelenmesi amaçlanmıştır. Astım,
alerjik rinit ve atopik dermatitli 71 hasta ve 54 sağlam çocuk çalışmaya
alınmıştır. Vücut kitle indeksleri, solunum fonksiyon testleri ve deri prick
testleri yapılan hastalardan total eozinofil sayısı, total serum Immunglobulin
E, spesifik Immunglobulin E (phadiotop), leptin ve adiponektin düzeyleri için
kan alınmıştır. Plazma leptin konsantrasyonu ile vücut kitle indeksi arasında
pozitif korelasyon saptanırken, plazma adiponektin düzeyleri ile vücut kitle
indeksi arasında negatif korelasyon saptanmıştır. Atopik dermatitli çocuklar
diğer hasta ve sağlıklı çocuklara göre daha yüksek leptin düzeylerine
sahiplerdi. Fakat adiponektin düzeyleri açısından böyle bir yüksekliğe
rastlanmadı. Serum leptin düzeyleri ile vücut kitle indeksi arasında güçlü
bir  pozitif korelasyon saptandı. Bu
sonuçlara göre serum leptin düzeyleri çocuklarda atopik dermatit riskiyle
ilişkilendirilebilirken, adiponektin düzeyleriyle böyle bir ilişki
saptanmamıştır.

Anahtar Kelimeler

Astım, leptin, adiponektin, alerjik rinit

Associatıons of Adipokines with Allergic Rhinitis, Asthma and Atopic Dermatitis in Children

Öz

There
is growing evidence for an association between adipokines and allergic
disorders but little is known about the underlying mechanisms. We hypothesized
that high plasma leptin and adiponectin concentrations might be related to
asthma and the other allergic diseases. We studied 71 children with allergic
diseases (asthma, allergic rhinitis, atopic dermatitis) and 54 healthy
children. Body mass indexes, pulmonary function tests and skin prick test were
performed.  Total eosinophil count, total
serum immunoglobulin E (IgE), serum spesific IgE (phadiotop)  leptin and adiponectin were measured in all
subjects. There was a strong positive correlation for plasma leptin
concentrations with body mass index BMI, Adiponectin, however, was negatively
correlated with BMI. Children with atopic dermatitis had higher leptin levels
compared with the other allergic diseases and control groups, but adiponectin
did not show any difference among these three groups. Serum leptin levels are
strongly correlated with measures of 
BMI. These results suggest that leptin may contribute to increased
atopic dermatitis risk in children. but no correlation was found with plasma
adiponectin concentrations

Anahtar Kelimeler

Asthma, leptin, adiponectin, allergic rhinitis

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