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Evaluation of D Vitamın Levels in Fibromyalgia Syndrome

Yıl 2019, Cilt: 41 Sayı: 2, 161 - 165, 01.04.2019
https://doi.org/10.20515/otd.459018

Öz

The aim of this study
was to evaluate 25(OH)D levels in patients with fibromyalgia syndrome and to
investigate the relationship between tender point count and 25(OH)D levels.
Sixty
one patients with a diagnosis of fibromyalgia were included in this
retrospective study between 2016-2017. Demographic data of patients,
25(OH)D levels, number
of tender points were evaluated. Patients were classified as vitamin D
deficiency (<20 ng/ml), vitamin D insufficient (20-30 ng/ml) and normal
vitamin D level (> 30 ng /ml) according to 25(OH)D levels. The mean 25(OH)D
levels of 61 patients with firomyalgia was 18.08±11.72. When vitamin D levels
were examined, vitamin D deficiency was found in 40 patients with fibromyalgia
and vitamin D deficiency in 14 patients with fibromyalgia. Only 7 (11,48%) of
the patients with fibromyalgia had normal vitamin D levels. There was no
significant correlation between 25(OH)D levels and tender point counts of
patients.
It was concluded that the vitamin D
levels were low in the majority of patients with fibromyalgia, however the
number of tender point detected in
patients with fibromyalgia was not related to 25(OH)D values. 

Kaynakça

  • 1) Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014;311(15):1547–1555.
  • 2) Wolfe F1, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. report of the Multicenter Criteria Committee. Arthritis Rheum. 1990 Feb;33(2):160-72.
  • 3) Bhatty SA, Shaikh NA, Irfan M, Kashif SM, Vaswani AS, Sumbhai A, et al. Vitamin D deficiency in fibromyalgia. J Pak Med Assoc 2010;60: 949-51.
  • 4) Altindag O, Ögüt E, Gur A, Gursoy S, Gunay M. Serum vitamin D level and its relation with clinical parameters in fibromyalgia as a neuropathic pain. Orthop Muscular Syst 2014;3: 171.
  • 5) Okyay R, Koçyigit B, Gürsoy S. Vitamin D levels in women with fibromyalgia and relationship between pain, tender point count and disease activity. Acta Med Mediterr 2016; 32: 243-7.
  • 6) Makrani AH, Afshari M, Ghajar M, Forooghi Z, Moosazadeh M. Vitamin D and fibromyalgia: a meta-analysis. Korean J Pain. 2017 Oct;30(4):250-257.
  • 7) Olama SM, Senna MK, Elarman MM, Elhawary G. Serum vitamin D level and bone mineral density in premenopausal Egyptian women with fibromyalgia. Rheumatol Int 2013; 33: 185-92.
  • 8) Tandeter H, Grynbaum M, Zuili I, Shany S, Shvartzman P. Serum 25-OH vitamin D levels in patients with fibromyalgia. Isr Med Assoc J 2009; 11: 339-42.
  • 9) Matthana MH. The relation between vitamin d deficiency and fibromyalgia syndrome in women. Saudi Med J. 2011;32:925–9.
  • 10) Armstrong DJ, Meenagh GK, Bickle I, et al. Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol. 2007;26:551–4.
  • 11) Warner AE, Arnspiger SA. Diffuse musculoskeletal pain is not associated with low vitamin D levels or improved by treatment with vitamin D. J Clin Rheumatol 2008;14(1): 12-16.
  • 12) Dogru A, Balkarli A, Cobankara V, Tunc SE, Sahin M. Effects of Vitamin D Therapy on Quality of Life in Patients with Fibromyalgia Eurasian J Med. 2017;49(2):113-117.
  • 13) Makrani AH, Afshari M, Ghajar M, Forooghi Z, Moosazadeh M. Vitamin D and fibromyalgia: a meta-analysis. Korean J Pain.. 2017;30(4):250-257.
  • 14) De Rezende Pena C, Grillo LP, Das Chagas Medeiros MM. Evaluation of 25-hydroxivitamin D serum levels in patients with fibromyalgia.J Clin Rheumatol. 2010;16:365–9.
  • 15) Hauser W, Walitt B, Fitzcharles MA, et al. Review of pharmacological therapies in fibromyalgia syndrome. Arthritis Res Ther 2014;16:201.
  • 16) Hauser W, Bernardy K, Uc¸eyler N, Sommer C. Treatment of fibromyalgia syndrome with gabapentin and pregabalin–a meta-analysis of randomized controlled trials. Pain 2009;145:69–81.
  • 17) Sultan A, Gaskell H, Derry S, Moore RA. Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials. BMC Neurol 20081;8:29.
  • 18) Goldenberg DL, Burckhardt C, Crofford L. Management of fibromyalgia syndrome. JAMA 2004;292:2388–95.
  • 19) Robinson RL, Kroenke K, Mease P, Williams DA, Chen Y, D’Souza D, Wohlreich M, McCarberg B. Burden of illness and treatment patterns for patients with fibromyalgia. Pain Med 2012;13:1366–76.
  • 20) Silverman S, Dukes EM, Johnston SS, Brandenburg NA, Sadosky A, Huse DM. The economic burden of fibromyalgia: comparative analysis with rheumatoid arthritis. Curr Med Res Opin 2009;25: 829–40.
  • 21) Thorpe J, Shum B, Moore RA, Wiffen PJ, Gilron I. Combination pharmacotherapy for the treatment of fibromyalgia in adults. Cochrane Database Syst Rev. 2018 Feb 19;2:CD010585.
  • 22) Gilron I, Chaparro LE, Tu D, Holden RR, Milev R, Towheed T, DuMerton-Shore D, Walker S. Combination of pregabalin with duloxetine for fibromyalgia: a randomized controlled trial. Pain. 2016 Jul;157(7):1532-40.

Fibromiyalji Sendromunda D Vitamin Düzeylerinin Değerlendirilmesi

Yıl 2019, Cilt: 41 Sayı: 2, 161 - 165, 01.04.2019
https://doi.org/10.20515/otd.459018

Öz

Bu çalışmanın amacı, fibromiyalji
sendromu olan hastalarda 25(OH)D düzeyini değerlendirmek ve hassas nokta sayısı ile 25(OH)D düzeyi arasındaki
ilişkiyi araştırmaktı. Bu retrospektif çalışmaya, 2016-2017 yılları arasında
fibromiyalji tanısı almış 61 hasta dahil edildi. Hastaların demografik
verileri, 25(OH)D düzeyleri, hassas nokta sayıları değerlendirildi. Hastalar 25(OH)D
düzeyleri göre;  D vitamini eksikliği
(<20 ng/ml), D vitamini yetersizliği (20-30 ng/ml) ve normal D vitamini
düzeyi olarak (>30 ng/ml)  sınıflandırıldı.
Fibromiyalji tanısı olan 61 hastanın 25(OH)D düzeyleri ortalaması 18,08±11,72
idi. D vitamin düzeyleri incelendiğinde, 40 fibromiyalji hastasında D vitamini
eksikliği, 14 fibromiyalji hastasında D vitamini yetersizliği olduğu saptandı. Fibromiyalji
tanısı olan hastaların sadece 7’sinde (%11,48) 
D vitamin düzeyleri normal seviyede bulunmuştur. Hastaların 25(OH)D düzeyleri
ve hassas nokta sayıları arasında anlamlı bir korelasyon gözlemlenmedi. Fibromiyaljili
 hastaların büyük çoğunluğunda vitamin D
düzeylerinin düşük olduğu, bununla birlikte fibromiyaljili hastalarda saptanan
hassas nokta sayısının 25(OH)D değerleriyle
ilişkili olmadığı sonucuna varılmıştır.  

Kaynakça

  • 1) Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014;311(15):1547–1555.
  • 2) Wolfe F1, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. report of the Multicenter Criteria Committee. Arthritis Rheum. 1990 Feb;33(2):160-72.
  • 3) Bhatty SA, Shaikh NA, Irfan M, Kashif SM, Vaswani AS, Sumbhai A, et al. Vitamin D deficiency in fibromyalgia. J Pak Med Assoc 2010;60: 949-51.
  • 4) Altindag O, Ögüt E, Gur A, Gursoy S, Gunay M. Serum vitamin D level and its relation with clinical parameters in fibromyalgia as a neuropathic pain. Orthop Muscular Syst 2014;3: 171.
  • 5) Okyay R, Koçyigit B, Gürsoy S. Vitamin D levels in women with fibromyalgia and relationship between pain, tender point count and disease activity. Acta Med Mediterr 2016; 32: 243-7.
  • 6) Makrani AH, Afshari M, Ghajar M, Forooghi Z, Moosazadeh M. Vitamin D and fibromyalgia: a meta-analysis. Korean J Pain. 2017 Oct;30(4):250-257.
  • 7) Olama SM, Senna MK, Elarman MM, Elhawary G. Serum vitamin D level and bone mineral density in premenopausal Egyptian women with fibromyalgia. Rheumatol Int 2013; 33: 185-92.
  • 8) Tandeter H, Grynbaum M, Zuili I, Shany S, Shvartzman P. Serum 25-OH vitamin D levels in patients with fibromyalgia. Isr Med Assoc J 2009; 11: 339-42.
  • 9) Matthana MH. The relation between vitamin d deficiency and fibromyalgia syndrome in women. Saudi Med J. 2011;32:925–9.
  • 10) Armstrong DJ, Meenagh GK, Bickle I, et al. Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol. 2007;26:551–4.
  • 11) Warner AE, Arnspiger SA. Diffuse musculoskeletal pain is not associated with low vitamin D levels or improved by treatment with vitamin D. J Clin Rheumatol 2008;14(1): 12-16.
  • 12) Dogru A, Balkarli A, Cobankara V, Tunc SE, Sahin M. Effects of Vitamin D Therapy on Quality of Life in Patients with Fibromyalgia Eurasian J Med. 2017;49(2):113-117.
  • 13) Makrani AH, Afshari M, Ghajar M, Forooghi Z, Moosazadeh M. Vitamin D and fibromyalgia: a meta-analysis. Korean J Pain.. 2017;30(4):250-257.
  • 14) De Rezende Pena C, Grillo LP, Das Chagas Medeiros MM. Evaluation of 25-hydroxivitamin D serum levels in patients with fibromyalgia.J Clin Rheumatol. 2010;16:365–9.
  • 15) Hauser W, Walitt B, Fitzcharles MA, et al. Review of pharmacological therapies in fibromyalgia syndrome. Arthritis Res Ther 2014;16:201.
  • 16) Hauser W, Bernardy K, Uc¸eyler N, Sommer C. Treatment of fibromyalgia syndrome with gabapentin and pregabalin–a meta-analysis of randomized controlled trials. Pain 2009;145:69–81.
  • 17) Sultan A, Gaskell H, Derry S, Moore RA. Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials. BMC Neurol 20081;8:29.
  • 18) Goldenberg DL, Burckhardt C, Crofford L. Management of fibromyalgia syndrome. JAMA 2004;292:2388–95.
  • 19) Robinson RL, Kroenke K, Mease P, Williams DA, Chen Y, D’Souza D, Wohlreich M, McCarberg B. Burden of illness and treatment patterns for patients with fibromyalgia. Pain Med 2012;13:1366–76.
  • 20) Silverman S, Dukes EM, Johnston SS, Brandenburg NA, Sadosky A, Huse DM. The economic burden of fibromyalgia: comparative analysis with rheumatoid arthritis. Curr Med Res Opin 2009;25: 829–40.
  • 21) Thorpe J, Shum B, Moore RA, Wiffen PJ, Gilron I. Combination pharmacotherapy for the treatment of fibromyalgia in adults. Cochrane Database Syst Rev. 2018 Feb 19;2:CD010585.
  • 22) Gilron I, Chaparro LE, Tu D, Holden RR, Milev R, Towheed T, DuMerton-Shore D, Walker S. Combination of pregabalin with duloxetine for fibromyalgia: a randomized controlled trial. Pain. 2016 Jul;157(7):1532-40.
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm ORİJİNAL MAKALELER / ORIGINAL ARTICLES
Yazarlar

Merih Özgen 0000-0002-8919-968X

Ayşe Merve Aydoğan Bu kişi benim 0000-0002-0223-6354

Ali Uygur Bu kişi benim 0000-0003-0673-5668

Onur Armağan 0000-0002-5917-5839

Funda Berkan 0000-0001-7531-3704

Fezan Mutlu 0000-0002-9339-4031

Yayımlanma Tarihi 1 Nisan 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 41 Sayı: 2

Kaynak Göster

Vancouver Özgen M, Aydoğan AM, Uygur A, Armağan O, Berkan F, Mutlu F. Evaluation of D Vitamın Levels in Fibromyalgia Syndrome. Osmangazi Tıp Dergisi. 2019;41(2):161-5.


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