Pregabalinin Gastrik Ülser Oluşumu ve Antioksidan Parametreler Üzerine Etkileri

Year 2020, Volume: 42 Issue: 1, 27 - 33, 01.01.2020

Bilgin Kaygisiz Sule Aydin Cafer Yildirim Hadi Karimkhani Setenay Oner Fatma Sultan Kilic

https://doi.org/10.20515/otd.475139

Cited By: 1

Abstract

Pregabalin epilepsi, ankisiyete
ve nöropatik ağrıda kullanılan analjezik etkiye sahip antiinflamatuvar bir
ajandır. Biz çalışmamızda pregabalinin sıçanlarda mide üzerine yan etkilerinin
olup olmadığını ve bir non-steridal antiinflamatuvar bir ajan ile etkisini
karşılaştırmayı amaçladık. Pregabalinin gastrik mukozal hasara karşı koruyucu
olduğu düşünülen antioksidan seviyeleri üzerine olan etkilerini de araştırdık.
Pregabalin 30, 50, 100 mg/kg, indometasin 5 mg/kg (referans-NSAID), salin
(kontrol grubu) 10 gün boyunca oral olarak uygulandı. 10 günlük tedavinin
sonunda, sıçanlar sakrifiye edildi, mide dokuları çıkarıldı, mukus salgılanması
spektrofotometrik olarak belirlendi, ülser indeksi 0'dan (no-peteşi) skor 3'e
(peteşi> 5mm) kadar skorlandı. Ayrıca pregabalinin mide dokusundaki
antioksidan etkilerini değerlendirmek üzere malondialdehid (MDA), katalaz ve
süperoksit dismutaz (SOD) aktiviteleri çalışıldı. Pregabalin 50 mg/kg ve 100
mg/kg dozları kontrol grubu ile karşılaştırıldığında indometazine benzer
şekilde anlamlı olarak mukus salgılanmasını azalttı ve ülser indeksini artırdı.
Pregabalin 30 mg/kg dozunda bu etki görülmedi. Pregabalin 30 mg/kg ve 100 mg/kg
SOD ve katalaz seviyelerini düşürüyorken pregabalin 100  mg/kg dozunda MDA seviyeleri artmıştır. 50
mg/kg and 100 mg/kg pregabalin mukus salgılanmasını ve ülser oluşumu
indometazin 30 mg/kg dozuna benzer şekilde azaltarak gastrik yan etkiler
göstermiştir. Pregabalin 30 mg/kg dozu ise gastrik yan etkilerin ortaya çıkmadığı
uygun doz olabilir. Pregabalin 50 mg/kg dozunun ise antioksidan seviyelerini
artırıcı etkiye sahip olduğu görülmüştür.

Keywords

pregabalin, malondialdehyde, superoxide dismutase, catalase, gastric mucus secretion

The Effects of Pregabalin on Gastric Ulcer Formation and Antioxidant Parameters

Abstract

Pregabalin, a drug used in
epilepsy, anxiety, neuropathic pain is reported to have analgesic effects in
inflammatory pain.  We aimed to
investigate whether pregabalin have gastric side effects and to compare with a
non steroidal antiinflammatory drug (NSAID) in rats. The effects of pregabalin
on antioxidant levels, which are suggested to protect against gastric mucosal
damage were also studied. Pregabalin 30, 50, 100 mg/kg, indomethacin 5 mg/kg
(reference-NSAID), saline (control group) were administered orally for 10 days.
At the end of 10 day treatment, rats were sacrificed,  gastric tissues were removed out,  mucus secretion was determined
spectrophotometrically, ulcer index was scored from score 0:(no-petechia) to
score 3:(petechia>5mm). Also, to evaluate the antioxidant effects of
pregabalin, malondialdehyde (MDA) levels, catalase and superoxide dismutase
(SOD) activities  in gastric tissue were
studied. Pregabalin 50 mg/kg and 100 mg/kg similar to indomethacin
significantly reduced mucus secretion and increased ulcer index compared to
control while pregabalin 30 mg/kg did not. Pregabalin 30 mg/kg and 100 mg/kg
decreased SOD and catalase levels. Pregabalin 100 mg/kg dose increased MDA
levels. 50 mg/kg and 100 mg/kg pregabalin showed gastric side effects as
reduced mucus secretion and ulcer formation similar to indomethacin and 30
mg/kg pregabalin may be reasonable dose without showing gastric side effects.
Pregabalin 50 mg/kg seems to have enhancing effects on antioxidant levels.

Keywords

pregabalin, malondialdehyde, superoxide dismutase

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