Hidroksiklorokinin tetiklediği akut generalize ekzantematöz püstülozis: Literatür eşliğinde bir olgu

Year 2020, Volume: 42 Issue: 2, 249 - 253, 17.03.2020

Erdal Bodakçi Nazife Şule Yaşar Bilge Ersoy Acer Deniz Arık Timuçin Kaşifoğlu

https://doi.org/10.20515/otd.573188

Abstract

Akut
generalize ekzantematöz püstülozis (AGEP), genel olarak ilaç ilişkili bir
reaksiyon olup, ödemli eritem zemininde akut gelişen, folliküler olmayan, steril
püstüller ile karakterize bir tablodur. Hidroksiklorokin
(HCQ), antimalaryal bir ilaç olup romatizmal ve dermatolojik hastalıkların
tedavisinde yaygın olarak kullanılmaktadır ve AGEP’in nadir nedenlerinden
biridir. 44 yaşında kadın hasta romatoid artrit nedenli hidroksiklorokin
alırken gelişen AGEP, HCQ’nin kesilmesi ve steroid tedavisinin başlanması ile düzeldi.
Bu olgudaki amacımız romatoloji pratiğinde sık kullanılan bir ilaç olan HCQ kullanımı
sonrası gelişebilecek oldukça nadir istenmeyen bir durum olan AGEP ile ilişkili
farkındalığı arttırmak ve bu istenmeyen etkinin yönetimini belirlemek.

Keywords

Akut generalize ekzantematöz püstülozis

Acute Generalized Exanthematous Pustulosis Induced by Hydroxychloroquine: Case Report and a Review of the Literature

Abstract

Acute generalized exanthematous pustulosis (AGEP)
is a clinical reaction pattern that is generally drug induced and characterized
by acute, nonfollicular sterile pustules on a background of edematous erythema.
Hydroxychloroquine (HCQ) is an
antimalarial drug which is widely used in dermatologic and rheumatologic
diseases and reported as a rare cause of AGEP. A
44 years old female patient developed AGEP while recieving HCQ for rheumatoid
arthritis and resolved after cessation of HCQ and starting steroid therapy. The
aim of this case is to raise the awareness about AGEP which is an uncommon and
undesired effect of HCQ; a widely used drug in rheumatology practice.  

Keywords

Acute generalized exanthematous pustulosis

References

• 1. Chaabane A, Aouam K, Gassab L, Njim L, Boughattas NA. Acute generalized exanthematous pustulosis (AGEP) indu¬ced by cefotaxime. Fundam Clin Pharmacol 2010;24(4):429-32.
• 2. Sidoroff A, Halevy S, Bouwes Bavinck JN, Vaillant L, Roujeau JC. Acute generalized exanthematous pustulosis (AGEP)-a clinical reactin pattern. J Cutan Pathol 2001;28:113-9.
• 3. Beylot C, Bioulac P, Doutre MS. Acute generalized exanthematic pustuloses (four cases). Ann Dermatol Venereol 1980;107:37-48.
• 4. Sidoroff A, Dunant A, Viboud C, et al. Risk factors for acute generalized exhanthematous pustulosis(AGEP)—results of amultinational case-control study (EuroSCAR). Br J Dermatol. 2007;157:989‐996.
• 5. Halevy S, Kardaun SH, Davidovici B, Wechsler J; EuroSCAR and RegiSCAR study group. The spectrum of histopathologi¬cal features in acute generalized exanthematous pustulosis: a study of 102 cases. Br J Dermatol 2010;163(6):1245-52.
• 6. Roujeau JC1, Bioulac-Sage P, Bourseau C, Guillaume JC, Bernard P, Lok C, et al. Acute generalized exanthematous pustulosis. Analysis of 63 cases. Arch Dermatol 1991;127:1333-1338.
• 7. Paradisi A, Bugatti L, Sisto T, et al. Acute generalized exanthematous pustulosis induced by hydroxychloroquine: three cases and a review of the literature. Clin Ther. 2008;30:930‐940.
• 8. Mohaghegh, F, Jelvan, M, Rajabı, P. A case of prolonged generalized exanthematous pustulosis caused by hydroxychloroquine—Literature review. Clinical case reports, 2018, 6.12: 2391.
• 9. Duman H, Topal IO, Kocaturk E, Cure K, Mansuroglu I. Acute generalized exanthematous pustulosis induced by hydroxychloroquine: a case with atypical clinical presentation. An Bras Dermatol. 2017;92(3):404‐406.
• 10. Bilge Şule Yaşar, Erdoğan Tuba. A Rare Side Effect Of Hydroxycholoroqine: Acute Generalised Exanthematous Pustulosis Hydroxycholoroqine Induced Cutaneous Lesions/Hidroksiklorokinin Nadir Bir Yan Etkisi: Akut Jeneralize Egzantamatöz Pustulozis. Osmangazi Tıp Dergisi, 2016, 39.1: 78-80.