Evaluation of Continuous and Pulsed Ultrasound Treatments on Knee Osteoarthritis: A Randomized and Placebo-Controlled Study

Year 2020, Volume: 42 Issue: 5, 482 - 488, 15.09.2020

Seda Öncel Merih Özgen Fulya Bakılan Ayşe Merve Aydoğan Ali Uygur Özkan Alataş Onur Armağan Funda Berkan Fezan Mutlu

https://doi.org/10.20515/otd.583926

Abstract

This study evaluates effects of therapeutic ultrasound (continue, pulsed, placebo) treatment on the clinical and biochemical parameters in knee osteoarthritis. 30 patients (30-70 aged) diagnosed with knee osteoarthritis were randomly separated into three groups. The 1st group includes 10 patients given continue ultrasound treatment (1 MHz, 2W/cm2), the 2nd group consists of 10 patients given pulsed ultrasound treatment (1MHz, 2 W/cm2, 1:4) and 3th group includes 10 patients given placebo ultrasound treatment (switch off). The patients were assessed before and one month after the treatment with WOMAC, COMP, Hs CRP, MMP-1, MMP-3 levels in serum and CTX-II levels in urine. When the demographic characteristics were compared, no statistically significant difference was found between the three groups in terms of age, body mass index and radiological staging ( p > 0.05). In terms of clinical parameters, there was an improvement in all three groups in the first month after treatment except WOMAC stiffness in pulsed and placebo groups, although no statistically significant difference was observed between the groups ( p > 0.05). In the evaluation of biochemical parameters, there was no significant difference between the groups in terms of pre-treatment and post-treatment 1 month, whereas there was a statistically significant difference between the group 1 and group 3 in favor of group 3 ( p = 0.019). The efficacy of therapeutic US (continuous / pulsed) which was applied short term and alone, on clinical and biochemical markers in knee osteoartrithis, has not been demonstrated.

Keywords

knee osteoarthritis, therapeutic ultrasound, biochemical marker

Supporting Institution

ESOGÜ BAP

Project Number

201211A203

Diz Osteoartritinde Sürekli ve Kesikli Ultrason Tedavilerinin Değerlendirilmesi: Randomize ve Plasebo Kontrollü Bir Klinik Çalışma

Abstract

Bu çalışma, diz osteoartritinde, terapotik sürekli, kesikli ve plasebo ultrason uygulamasının, klinik ve biyokimyasal etkinliğini karşılatırmak amacıyla yapılmıştır. Diz osteoartriti tanısı alan 30 hasta üç gruba ayrıldı. 1. gruba sürekli ultrason (1 MHz, 2 W / cm2); 2. gruba kesikli ultrason (1MHz,2W/cm2,1:4); 3. gruba ise plasebo ultrason tedavisi uygulandı. Tüm gruplar 10 gün (5 dakika/seans) tedavi aldı. Hastalar tedavi öncesi ve tedavi sonrası 1. ayda WOMAC, serum hs - CRP, COMP, MMP - 1, MMP - 3 ve idrar CTX - II düzeyleri ile değerlendirildi. Demografik özellikler karşılaştırıldığında, üç grup arasında yaş, vücut kitle indeksi ve radyolojik evreleme açısından istatistiksel olarak anlamlı bir fark bulunmadı ( p > 0.05 ). Klinik parametreler açısından, tedaviden sonraki ilk ayda, plasebo grubunda WOMAC sertlik dışında, her üç grupta iyileşme saptandı, ancak gruplar arasında istatistiksel olarak anlamlı bir fark gözlenmedi ( p > 0.05 ). Biyokimyasal parametrelerin 1. ay değerlendirilmesinde tedavi öncesi ve tedavi sonrası gruplar arasında anlamlı fark bulunmazken, grup 1 ve grup 3 arasında grup 3 lehine istatistiksel olarak anlamlı bir fark vardı ( p = 0.019 ). Diz OA’de tek başına ve kısa süreli uygulanan terapötik ultrasonun (sürekli/kesikli) klinik ve biyokimyasal belirteçler üzerine etkinliği gösterilememiştir.

Keywords

diz osteoartriti, terapotik ultrason, biyokimyasal belirteç

Project Number

201211A203

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