In our study, patients diagnosed with Hodgkin lymphoma (HL) between January 2008 and December 2018 in our clinic; We aimed to determine demographic, histopathological and prognostic features and to reveal the relationship of these markers on survival. In our study, the data of 130 patients who were diagnosed with Hodgkin lymphoma in Eskişehir Osmangazi University Faculty of Medicine Hematology Department between 2008-2018 according to the World Health Organization (WHO) 2008 classification were analyzed retrospectively. 61.5% (n = 80) of the 130 patients included in the study were male, the mean age was 46.5 ± 15.8 (20-89) years. At the time of diagnosis, 37.7% of the patients were in the early stage and 62.3% were in the advanced stage. The most common diagnosis was made in stage (34.6%). 93.1% of the patients were diagnosed with classical HL and 6.9% with nodular lymphocyte predominant HL. Of the patients with classic HL, 49.6% were diagnosed with nodular sclerosing HL (NSHL), 15.7% with mixed cellular HL, 7.4% with lymphocyte-rich HL, 3.3% with lymphocyte-poor HL, 24% with classic HL but no subtype specified. NSHL was the most common histological subgroup in all patients, women, and men. Looking at overall survival (OS) and relapse-free survival (RFS) by stages, it was highest in stage Ⅰ and lowest in stage Ⅳ. Considering all patients, 5-year OS was 88.7%, 5-year RFS was 83.9%, 10-year OS was 82.2%, 10-year RFS was 82.4%. In the evaluation of prognostic factors, age (p = 0.001), extranodal involvement (p = 0.007), bone marrow involvement (p = 0.05), ECOG performance score (p <0.001), presence of B symptoms (p = 0.049), hemoglobin (p <0.0001) ), albumin (p <0.0001), alkaline phosphatase (ALP) (p = 0.0001) were found to have a significant effect on mortality in univariate analysis. In multivariate analysis, age (p <0.001), albumin (p = 0.041), ALP (p = 0.005), leukocyte count (p = 0.028) were determined as prognostic factors. Most of the patients are at advanced stage at diagnosis, and their overall and relapse-free survival of 5 and 10 years decreases as the stage increases. Age, extranodal involvement, bone marrow involvement, ECOG performance, presence of B symptoms, anemia, hypoalbuminemia, ALP and leukocyte count are prognostic factors that affect overall survival.
|Subjects||Health Care Administration|
|Journal Section||ORİJİNAL MAKALE|
|Publication Date||September 24, 2021|
|Published in Issue||Year 2021 Volume: 43 Issue: 6|