Kan Grubu Farklılıkları Larinks Kanseri Gelişiminde Belirleyici Bir Faktör Olabilir Mi?

Year 2022, Volume: 44 Issue: 2, 204 - 210, 28.02.2022

Hasan Çanakcı

https://doi.org/10.20515/otd.951140

Abstract

Literatürde larinks kanseri ve kan grupları arasındaki ilişkinin araştırıldığı çalışmalarda tartışmalı sonuçlar mevcuttur. Çalışmamızın amacı kan grubu farklılıkları ve larinks kanser gelişim evreleri arasındaki olası ilişkinin incelenmesidir. Çalışmamıza 3. Basamak bir sağlık kuruluşunda Kulak Burun Boğaz Hastalıkları ve Baş Boyun Cerrahisi Kliniği’nde 01 Ocak 2014- 31 Ekim 2020 yılları arasında, larinks patolojisi ön tanısı ile direkt laringoskopi altında biyopsi operasyonu geçirmiş olan 251 hastanın dosyaları geriye dönük olarak incelenmiştir. Hastaların yaş, cinsiyet, kan grubu verileri ve histopatolojik tanıları değerlendirilmiştir. Hastalar histopatolojik tanılarına göre % 32,65 oranında benign (n:64), %38,78 oranında premalign (n:76) ve %28,57 oranında malign (n:56) laringeal lezyon olarak gruplandırılmıştır. Gruplar yaş açısından karşılaştırıldığında yaş ortalaması malign laringeal lezyon grubunda premalign laringeal lezyon grubundan, premalign laringeal lezyon grubunda da benign laringeal lezyon grubundan anlamlı şekilde yüksektir (p<0,001). Cinsiyet dağılımına bakıldığında erkek cinsiyet oranı malign laringeal lezyon grubunda premalign laringeal lezyon grubundan, premalign lezyon grubunda da benign laringeal lezyon grubundan anlamlı şekilde yüksektir (p<0,001). Gruplar arasında kan grupları açısından kıyaslama yapıldığında A kan grubu taşıyan hasta oranı malign laringeal lezyon ve premalign laringeal lezyon gruplarında benign laringeal lezyon grubuna göre anlamlı bir şekilde yüksek bulunmuştur (sırasıyla p=0,005, p=0,025). Diğer kan grupları dağılımında istatistiksel açsından anlamlı bir fark saptanmamıştır. Bu bulgularla larinks kanseri gelişimi sürecinde ya da tanılı hastaların takiplerinde A kan grubuna sahip bireylerin malignleşme potansiyellerinin daha fazla olabilme ihtimali sebebiyle yakın takip edilmesinin faydalı olacağını düşünmekteyiz.

Keywords

Larinks kanseri, Kan grubu, Displazi, Risk faktörü

Supporting Institution

Destekleyen kurum bulunmamaktadır.

Can Abo Blood Groupıng Be A Rısk Factor For Laryngeal Cancer?

Abstract

There are controversial results in studies investigating the relationship between laryngeal cancer and blood group in the literature. The aim of our study is to examine the possible relationship between blood group and laryngeal cancer. 251 cases who had undergone direct laryngoscopy and biopsy with the diagnosis of laryngeal pathology, in the Department of Otorhinolaryngology and Head and Neck Surgery of a 3rd level healthcare institution in the period between January 01,2014 and October 31,2020 were analyzed. The age, gender, blood group and histopathological diagnosis of the cases were evaluated. According to their histopathological diagnosis, the cases were grouped as benign (32,65%, n:64), premalignant (38.78%, n:76) and malignant laryngeal lesion (28.57%, n:56). When the groups were compared in terms of age, the mean age was significantly higher in the malignant laryngeal lesion group than in the premalignant group and in the premalignant laryngeal lesion group than in the benign group (p<0.001). Considering the gender distribution, male sex ratio was significantly higher in the malignant laryngeal lesion group than in the premalignant group, and in the premalignant lesion group compared to the benign group (p<0.001). When the blood groups were compared between the groups, the rate of te cases with blood group A was found to be significantly higher in the malignant laryngeal lesion and premalignant laryngeal lesion groups compared to the benign laryngeal lesion group (p=0.005, p=0.025, respectively). No statistically significant difference was found in the distribution of other blood groups. As a result, we think that the close follow up of the cases diagnosed premalign laryngeal lesions or laryngeal cancer with blood group A would be useful because of the high potential of the canserization of the cases wth the blood group A suffer from the laryngeal lesions.

Keywords

Larynx cancer; blood group; dysplasia; risc factors.

References

• Kum RO, Ozcan M, Baklaci D, Kum NY, Yilmaz YF, Gungor V, et al. Elevated neutrophil-to-lymphocyte ratio in squamous cell carcinoma of larynx compared to benign and precancerous laryngeal lesions. Asian Pac J Cancer Prev 2014;15:7351-5.
• Kara F, Keskinkılıç B, Türkiye Kanser isatistikleri 2016, Halk Sağlığı Genel Müdürlüğü, Sağlık Bakanlığı, Ankara, 2019.
• Jin T, Li PJ, Chen XZ, Hu WH. ABO blood group is a predictor of survival in patients with laryngeal cancer. Chin J Cancer. 2016; 35: 90.
• Adam SI, Wılson KM, Overholser SM, et al. Are laryngeal squamous cell carcinoma incidence and patient mortality a function of ABO blood grouping? A retrospective study. J Laryngol Otol. 2012 ;126(2):180-4
• Li X, Gao L, Li H, Gao J, et al. Human papillomavirus infec‑ tion and laryngeal cancer risk: a systematic review and meta‑analysis. J Infect Dis. 2013;207:479–88.
• Edgren G, Hjalgrim H Rostgaard K, et al. Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. Am J Epidemiol. 2010;172(11):1280‐5.
• Zhang BL, He N, Huang YB, Song FJ, Chen KX. ABO blood groups and risk of cancer: a systematic review and meta‐analysis. Asian Pac J Cancer Prev. 2014;15(11):4643‐50
• Celestino D, Silvagni C. On the distribution of blood groups of ABO system in individuals with laryngeal carcinoma. Valsalva 1964;40:211–6
• Abd El Aal MS., Mohammed Roushdy MM., Mohamed El-Naggar, MS. Abd Allah Hussein, AA. ABO grouping as a risk factor for cancer larynx. EJNSO. 2020; 6(2): 20-6.
• Gale N, Poljak M, Zidar N. Update from the 4th edition of the World Health Organization Classification of head and neck tumours: what is new in the 2017 WHO blue book for tumours of the Hypopharynx, Larynx, Trachea and Parapharyngeal Space. Head Neck Pathol. 2017; 11(1):23–32
• Haddad RI, Shin DM. Recent advances in head and neck cancer. N Engl J Med, 2008;359: 1143-54
• Nocini R, Molteni G, Mattiuzzi C, Lippi G.Updates on larynx cancer epidemiology.Chin J Cancer Res. 2020 ;32(1):18-25.
• Koyanagi YN, Matsuo K, Ito H, et al. Cigarette smoking and the risk of head and neck cancer in the Japanese population: a systematic review and meta-analysis. Jpn J Clin Oncol. 2016;46(6):580-95.
• Licitra L, Bernier J, Grandi C, et al. Cancer of the larynx. Crit Rev Oncol Hematol. 2003;47(1):65-80.
• Altieri A, Bosetti C, Talamini R, et al. Cessation of smoking and drinking and the risk of laryngeal cancer. Br J Cancer. 2002;87(11):1227.
• Reid ME, Mohandas N. Red blood cell blood group antigens: structure and function. Semin Hematol. 2004;41:93–117.
• Mansour AH, Mohammed AM, Anwar R, et al. ABO blood group and risk of malignancies in Egyptians. International J of Cancer Research 2014;10(2):81-95.
• Ozkasap S, Dereci S, Sahin K, et al. Analysis of ABO and Rh blood groups distribution in East Karadeniz region of Turkey. Dicle Med. 2013; 40 (1): 100-4.
• Garratty G, SA, McEntire R ABO and Rh(D) phenotype frequencies of different racial/ethnic groups in the United States. Transfusion. 2004 May;44(5):703-6.
• Ravn V, Dabelsteen E. Tissue distribution of histo- blood group antigens. APIMS 2000;108(1):1-28.
• Strrauchen JA, Bergman SM, Hanson TA. Expression of A and B tissue isoantigens in benign and malignant lesions of the breast. Cancer. 1980;45:2149–55.
• Schuessler MH, Pintado S, Welt S, Real FX, Xu M, Melamed MR, et al. Blood group and blood‑group‑related antigens in normal pancreas and pancreas cancer: enhanced expression of precursor type 1, Tn and sialyl‑Tn in pancreas cancer. Int J Cancer. 1991;47:180–7.
• Kumar T, Puri G, Laller S, Bansal T, Malik M. Association of ABO blood grouping with oral lichen planus. Univ Res J Dent. 2014;4:93‑6.
• Guleria K, Singh HP, Kaur H, et al. ABO blood groups in gastrointestinal tract and breast carcinoma patients. Anthropologist 2005;7(3):189-92.
• Dabelsteen E. Cell surface carbohydrates as prognostic markers in human carcinomas. J Pathol 1996;179:358–69.
• Nowinska E, Namyslowski G, Scierski W, Kocierz S. ABO blood groups in patients with laryngeal cancer (in Polish). Otolaryngol Pol 2000;54(31):209–11.
• Rao MSS, Abraham TT. A retrospective study of blood groups in head and neck malignancies. J. Evid. Based Med. Healthc. 2018; 5(10), 908-12.
• Singh K, Kote S, Patthi B, et al. Relative Risk of various head and neck cancers among different blood groups: an analytical study. J Clin Diagn Res 2014;8(4):ZC25-8.
• Sadri M, McMahon J, Parker A. Management of laryngeal dysplasia: a review. Eur Arch Otorhinolaryngol. 2006;263:843–52.
• Marionneau S, Moullac-Vaidye LM, Pendu JL. Expression of histo-blood group A antigen increases resistance to apoptosis and facilitates escape from immune control of art colon carcinoma cells. Glycobiology 2002;12(12):851-56.