Prediyabet Durumunda Kardiyovasküler Riskin Öngörülmesi: Bozulmuş Açlık Glukozu Olan Bireylerde Aterojenik Plazma İndeksinin Rolü

Year 2023, Volume: 45 Issue: 5, 796 - 804, 27.09.2023

Hakan Şıvgın

https://doi.org/10.20515/otd.1345956

Abstract

Aterojenik plazma indeksi (API), kardiyovasküler hastalık riskini tahmin etmek için kullanılan nispeten yeni bir indekstir. API’nin metabolik sendrom, yüksek açlık plazma glukoz (FPG) ve diabetes mellitus ile ilişkili olduğu gösterilmiştir. Bununla birlikte, açlık plazma glukozu oral glukoz tolerans testi (OGTT) 2. saat plazma glukozu ve hemoglobin A1c (HbA1c) kombinasyon testleri kullanılarak API ile bozulmuş açlık glukozu arasındaki ilişkiyi araştıran bir çalışma yapılmamıştır. API, trigliseritin yüksek yoğunluklu lipoprotein kolesterole molar oranının logaritmasını içeren formül kullanılarak hesaplandı. Glikoz metabolizması parametreleri ve saptanan diyabet durumları ile API arasındaki ilişki analiz edildi.: Çalışma katılımcıları arasında prediyabet ve diyabet sıklığı sırasıyla %35,3 (n=58) ve %25,3 (n=40) idi. Katılımcıların %28,1’i düşük risk grubunda (API<0,11), %18,2’si orta risk grubunda (API 0,11-0,21) ve %53,6’sı yüksek risk grubunda (API>0,21) idi. Yüksek AIP (yüksek risk grubu), prediyabet ve diyabet ile önemli ölçüde ilişkiliydi. HbA1c, FPG ve OGTT 2.saat plazma glukoz seviyeleri ile API önemli ölçüde ilişkiliydi. AIP, bozulmuş açlık glukozu ve metabolik sendrom parametreleri ile önemli ölçüde ilişkiliydi. API gibi lipid panelli basit hesaplamalar, prediyabet ve diyabetli hastalarda kardiyovasküler hastalık riskini değerlendirmek için bilgi sağlayabilir.

Keywords

Aterojenik Plazma İndexi, Prediyabet, Diabetes mellitus, Dislipidem

Predicting Cardiovascular Risk In Prediabetes Status: The Role Of Atherogenic Plasma Index In Individuals With Impaired Fasting Glucose

Abstract

Atherogenic plasma index (API) is a relatively new index used in the general population for predicting the risk of cardiovascular disease. High fasting plasma glucose (FPG) levels have been shown to be associated with diabetes mellitus and metabolic syndrome, and API. However, no study has been conducted on the relationship between impaired fasting glucose identified using fasting and 2-hour plasma glucose in the oral glucose tolerance test, hemoglobin A1c (HbA1c) levels, and API. API was calculated using the logarithm of the molar ratio of triglycerides to high-density lipoprotein cholesterol. The relationship between glucose metabolism parameters with diabetes status and API was analyzed. The frequency of prediabetes and diabetes in the study participants was 35.3% (n=58) and 25.3% (n=40), respectively. 40 individuals were identified as Type 2 diabetes (fasting glucose >125 mg/dl, OGTT 2nd hour >200 mg/dl), 58 as impaired fasting glucose (IFG) prediabetes (fasting glucose: 100-125 mg/dl, OGTT 2nd hour <140mg/dl), and 66 individuals as a non-diabetic control group (glucose <100 mg/dL). 28.1% of participants were in the low-risk group (API<0.11), 18.2% were in the medium-risk group (API 0.11-0.21), and 53.6% were in the high-risk group (API>0.21). High API (high-risk group) was found to be significantly associated with prediabetes and diabetes status. API was also significantly associated with HbA1c, FPG, and 2-hour plasma glucose levels in the OGTT. AIP was significantly associated with the param¬eters of diabetes and prediabetes. Simple calculations made from fasting lipid panel results can be provide more information in assessing the risk of cardiovascular disease with IFG patients in prediabetes status.

Keywords

Atherogenic plasma index, Prediabetes, Diabetes mellitus, Dyslipidemia

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