Warthin tumor: Assessment of association with salivary gland and non-salivary gland malignant tumors via clinicopathological and radiological data

Year 2024, Volume: 46 Issue: 3, 404 - 412, 27.05.2024

Fatih Yılmaz Fuat Açıkalın Mehmet Özgür Pınarbaşlı Ercan Kaya İlknur Ak

https://doi.org/10.20515/otd.1402983

Abstract

This study aims to find out the incidence of malignant tumors originating from the salivary gland or other organs in patients with Warthin tumor (WT) and compare the clinicopathological, radiological, and demographic data of WT patients with or without malignant tumors. The study population consisted of 170 patients diagnosed with WT from cytology, surgery, and consultation materials between 2010 and 2021 in our hospital. Patient files were reviewed in terms of demographic data, smoking status, presence of malignant tumor, radiological findings, symptom duration, and operation procedure. A total of 40 malignant tumors were detected in 36 (21.2%) of 170 patients with WT. The most common localizations of malignant tumors were lung (35.0%), head and neck (35.0%), and genitourinary (12.5%) regions. The mean age of the patients with malignant tumor diagnosis (62.1±9.2) was higher than the patients without (56.5±9.8) (p=0.002). There was no significant difference between cases with and without malignant tumors in terms of gender, multifocality, bilaterality, amount of smoking, and pain complaints (p>0.05). The SUVmax of WTs ranged from 3 to 17.7 (median: 6.8, IQR: 5.5-11.0), and that of malignant tumors ranged from 2.7 to 16.2 (median: 8, IQR: 5.1-10.3) (p=0.756). This study demonstrates that WT can be seen with malignant tumors synchronously but also encountered before and after the malignant tumor diagnosis. This possibility should be considered, especially in the head and neck region, in patients diagnosed with malignant tumors or being investigated.

Keywords

Warthin tumor, Malignant tumor, Incidence, PET-CT

Warthin tümörü: Tükürük bezi ve tükürük bezi dışı malign tümörler ile ilişkisinin klinikopatolojik ve radyolojik veriler ile değerlendirilmesi

Abstract

Bu çalışmanın amacı, Warthin tümörü (WT) olan hastalarda tükürük bezi veya diğer organlardan kaynaklanan malign tümörlerin görülme sıklığını bulmayı ve malign tümörü olan ve olmayan WT hastalarının klinikopatolojik, radyolojik ve demografik verilerini karşılaştırmayı amaçlamaktadır. Çalışma popülasyonunu 2010-2021 yılları arasında hastanemizde sitoloji, cerrahi ve konsültasyon materyallerinden WT tanısı alan 170 hasta oluşturmuştur. Hasta dosyaları demografik veriler, sigara içme durumu, malign tümör varlığı, radyolojik bulgular, semptom süresi ve operasyon şekli açısından incelendi. WT'li 170 hastanın 36'sında (%21.2) toplam 40 malign tümör tespit edildi. Malign tümörlerin en sık lokalizasyonları akciğer (%35.0), baş-boyun (%35.0) ve genitoüriner (%12.5) bölge idi. Malign tümör tanısı olan hastaların ortalama yaşı (62.1±9.2), olmayan hastalara göre (56.5±9.8) daha yüksekti (p=0.002). Malign tümörü olan ve olmayan olgular arasında cinsiyet, multifokalite, bilateralite, sigara içme miktarı ve ağrı şikayeti açısından anlamlı fark yoktu (p>0.05). WT'lerin SUVmaks'ı 3 ila 17.7 (medyan: 6.8, IQR: 5.5-11.0) arasında, malign tümörlerin SUVmaks'ı ise 2.7 ila 16.2 (medyan: 8, IQR: 5.1-10.3) arasında değişmekte idi (p=0.756). Bu çalışma, WT'nin malign tümörlerle eş zamanlı olarak görülebildiği gibi, malign tümör tanısı öncesinde ve sonrasında da karşılaşılabileceğini göstermektedir. Özellikle baş-boyun bölgesinde, malign tümör tanısı olan ya da araştırılan hastalarda bu olasılık göz önünde bulundurulmalıdır.

Keywords

Warthin tümörü, Malign tümör, İnsidans, PET-CT

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