The Dual Burden of Obesity and Asthma: Implications for Respiratory Health and Asthma Control in Adults with Asthma

Yıl 2025, Cilt: 47 Sayı: 5, 694 - 705, 04.09.2025

Esra Nur Arslan , Turgut Öztutgan , Meltem Kaya

https://doi.org/10.20515/otd.1667506

Öz

Asthma and obesity are both highly prevalent conditions with significant public health implications, and obesity has been identified as an aggravating factor in the pathogenesis of asthma. The present study aims to investigate differences in pulmonary function, lung diffusion capacity, functional exercise capacity, and asthma control between obese and non-obese adults with asthma. Fifty asthma patients were divided equally into obese and non-obese groups. Participants performed pulmonary function test (PFT), lung diffusion capacity, six-minute walk test (6MWT), and Asthma Control Test (ACT). No significant differences were found among groups in terms of PFT, lung diffusion capacity, and ACT (p>0.05). Significant differences were observed between groups in end-test SpO₂ (p = 0.045), baseline and end-test systolic blood pressure (p = 0.017 and p = 0.002), end-test respiratory rate (p = 0.002), perceptions of dyspnea and fatigue at both baseline and end-test (all p < 0.05), end-test leg pain (p = 0.045), and total walking distance (p = 0.038). A moderate and statistically significant negative correlation was found between body mass index (BMI) and the 6MWT distance (r = –0.592, p = 0.028). This study reveals that functional capacity is significantly impaired in patients with mild asthma, and obesity further aggravates this limitation. These results highlight the need for early functional evaluation and reinforce the importance of incorporating structured exercise and weight control into comprehensive asthma rehabilitation programs.

Anahtar Kelimeler

Asthma , Asthma control , Functional exercise capacity , Lung diffusion capacity , Obesity , Pulmonary function test

Etik Beyan

The study was approved by the ethics committee of Istanbul Atlas University (date: 09.10.2023 protocol number: 08.07). The study was conducted in accordance with the Declaration of Helsinki

Destekleyen Kurum

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Teşekkür

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Obezite ve Astımın İkili Yükü: Astımlı Yetişkinlerde Solunum Sağlığı ve Astım Kontrolü Üzerindeki Etkileri

Öz

Astım ve obezite, her ikisi de önemli halk sağlığı sorunları olan yaygın durumlardır ve obezitenin astımın patogenezinde kötüleştirici bir faktör olduğu belirlenmiştir. Bu çalışma, astımı olan obez ve obez olmayan yetişkinler arasında akciğer fonksiyonları, akciğer diffüzyon kapasitesi, fonksiyonel egzersiz kapasitesi ve astım kontrolü açısından farklılıkları araştırmayı amaçlamaktadır. Elli astım hastası eşit şekilde obez ve obez olmayan iki gruba ayrılmıştır. Katılımcılara solunum fonksiyon testi (SFT), akciğer diffüzyon kapasitesi testi, altı dakikalık yürüme testi (6DYT) ve Astım Kontrol Testi (AKT) uygulanmıştır. Gruplar arasında SFT, akciğer diffüzyon kapasitesi ve AKT açısından anlamlı bir fark bulunmamıştır (p>0.05). Gruplar arasında test sonu SpO₂ (p = 0.045), başlangıç ve test sonu sistolik kan basıncı (p = 0.017 ve p = 0.002), test sonu solunum hızı (p = 0.002), hem başlangıç hem de test sonunda nefes darlığı ve yorgunluk algısı (tüm p < 0.05), test sonu bacak ağrısı (p = 0.045) ve toplam yürüme mesafesi (p = 0.038) açısından anlamlı farklar gözlemlenmiştir. Vücut kitle indeksi (VKİ) ile 6DYT mesafesi arasında orta düzeyde ve istatistiksel olarak anlamlı negatif bir korelasyon bulunmuştur (r = –0.592, p = 0.028). Bu çalışma, hafif astımı olan hastalarda fonksiyonel kapasitenin belirgin şekilde bozulduğunu ve obezitenin bu kısıtlamayı daha da kötüleştirdiğini ortaya koymaktadır. Bu sonuçlar, erken fonksiyonel değerlendirme gerekliliğini vurgulamakta ve yapılandırılmış egzersiz ile kilo kontrolünü içeren kapsamlı astım rehabilitasyon programlarının önemini pekiştirmektedir.

Anahtar Kelimeler

Akciğer Difüzyon Kapasitesi , Astım , Astım kontrolü , Fonksiyonel egzersiz kapasitesi , Obezite , Solunum Fonksiyon Testi

Kaynakça

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