Intrahepatic Cholestasis of Pregnancy and Maternal-Fetal Results

Abstract

Objective: Occurring frequently after the late second trimester intrahepatic cholestasis of pregnancy (ICP) is a widespread liver disease in the period of pregnancy. The general incidence of IC depending on the geographic variations, is probably to vary from 1% to 27.6%. In the study, it was aimed to report the maternal and fetal outcomes of women with ICP at our university hospital center.
Materials and Methods: The study was performed retrospectively on 44 pregnancies complicated by ICP between June 2018 and December 2020, at our Education and Research Hospital. Demographic characteristics, liver enzymes, a gestational week at diagnosis, type and time of delivery, APGAR scores at birth, and newborn weight and information about the patients included in the study were obtained from hospital records.
Results: The number of primiparous women was 27 (61%). In 4 (9.1%) women had preeclampsia and 4 (9.1%) women had gestational diabetes mellitus (GDM). Only one of the neonates had Apgar at the birth 1/5, 0 and 0 respectively.
Conclusion: In our study one perinatal death was observed, although no adverse maternal outcomes were observed. We recommend that ICP be managed individually. Close monitoring and active management are required in the prevention of complications. 

Keywords

• Intrahepatic cholestasis
• pregnancy
• perinatal outcomes

Gebeliğin Intrahepatik Kolestazı ve Maternal-Fetal Sonuçları

Öz

Amaç: Sıklıkla ikinci trimesterin sonlarından itibaren ortaya çıkan intrahepatik gebelik kolestazı, gebelik döneminde görülen yaygın bir karaciğer hastalığıdır. Coğrafi varyasyonlara bağlı olarak genel insidansı %1 -%27,6 arasında değişmektedir. Bu çalışma, üniversite hastanemizde Gebeliğin İntrahepatik Kolestazı tanılı kadınların maternal ve fetal sonuçlarını bildirmeyi amaçladı.
Materyal ve Metot: Çalışma Eğitim ve Araştırma Hastanemizde, Haziran 2018-Aralık 2020 tarihleri ​​arasında Gebeliğin İntrahepatik Kolestazı (GİK) ile komplike olan 44 gebede retrospektif olarak yapıldı. Çalışmaya dahil edilen olguların (n=44) demografik özellikleri, karaciğer enzimleri, tanı aldığı gebelik haftası, doğum şekli ve zamanı, doğumda APGAR skorları, yenidoğanın kilosu ve hasta bilgileri hastane kayıtlarından alındı.
Bulgular: Primipar kadın sayısı 27 (%61) idi. 4 (%9,1) kadında preeklampsi ve 4 (%9,1) kadında gestasyonel diabetes mellitus (GDM) izlendi. Yenidoğanlardan sadece birinde doğumda 1. ve 5. dakika APGAR scorları sırasıyla 0 ve 0 idi.
Sonuç: Çalışmamızda herhangi bir olumsuz maternal sonuç gözlenmemesine rağmen, bir perinatal ölüm izlendi. GİK'nin bireysel olarak yönetilmesini öneririz. Komplikasyonların önlenmesinde yakın takip ve aktif yönetim gereklidir. 

Anahtar Kelimeler

• İntrahepatik kolestaz
• gebelik
• perinatal sonuçlar

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