Evaluation of Oxidative Stress Marker and Ischemia Modified Albumin Levels in Patients with Psoriasis Vulgaris

Abstract

Objective: As a systemic inflammatory skin disease, psoriasis vulgaris (PS) is associated with cellular immune mechanisms. We aimed to evaluate oxidative stress markers and ischemia modified albumin levels in patients with PS and controls.

Materials and Methods: The participants (over age of 18) who applied to the dermatology outpatient clinic between September 2020 - May 2021 and diagnosed with PS (n=50) were enrolled into the study. Oxidative stress markers such as nitric oxide (NO), malondialdehyde (MDA), 8-hydroxy 2-deoxy guanosine (8-OHdG), superoxide dismutase (SOD), glutathione peroxidase (GPx) parameters and ischemia modified albumin (IMA) levels in patients with PS and controls were evaluated.

Results: A total of 100 volunteers, 50 with PS and 50 healthy controls were enrolled in the study. In the measurements of oxidative stress markers, GPX, 8-OHdG, MDA, IMA, IMA/Albumin and NO parameters were found to be statistically as significant between the patient and control groups. Also, SOD, 8-OHdG, IMA and NO were found to be statistically as significant between two psoriasis severity index (PASI) groups.

Conclusion: Elevated levels of 8-OHdG, MDA, IMA, IMA/Albumin, NO and decreased levels of GPx were observed in patients with PS. To clarify this topic, further and comprehensive studies are needed.

Keywords

• Oxidative stress
• ischemia modified albumin
• psoriasis vulgaris

Psoriazis Vulgaris' li Hastalarda Oksidatif Stres Belirteci ve İskemi Modifiye Albümin Düzeylerinin Değerlendirilmesi

Öz

Amaç: Sistemik inflamatuar bir deri hastalığı olan psoriazis vulgaris (PS), hücresel immün mekanizmalarıyla ilişkilidir. Çalışmamızın amacı PS' li hastalarda ve kontrollerde oksidatif stres belirteçleri ve iskemi modifiye albümin düzeylerini değerlendirmektir.

Materyal ve Metot: Eylül 2020 - Mayıs 2021 tarihleri ​​arasında dermatoloji polikliniğine başvuran ve PS tanısı konan (18 yaş üstü) katılımcılar (n=50) çalışmaya alındı. PS hastalarında nitrik oksit (NO), malondialdehit (MDA), 8-hidroksi 2-deoksi guanozin (8-OHdG), süperoksit dismutaz (SOD), glutatyon peroksidaz (GPx) parametreleri ve iskemi modifiye albümin (IMA) seviyeleri gibi oksidatif stres belirteçleri ve kontroller belirlenerek aralarındaki ilişkiler değerlendirildi.

Bulgular: Çalışmaya 50 PS' li ve 50 sağlıklı kontrol olmak üzere toplam 100 gönüllü alındı. Oksidatif stres belirteçlerinin ölçümlerinde GPX, 8-OHdG, MDA, IMA, IMA/Albumin ve NO parametreleri hasta ve kontrol grupları arasında istatistiksel olarak anlamlı bulundu. Ayrıca iki psoriazis alanı ve şiddet indeksi (PASI) grubu arasında SOD, 8-OHdG, IMA ve NO istatistiksel olarak anlamlı bulundu.

Sonuç: PS' li hastalarda 8-OHdG, MDA, IMA, IMA/Albumin, NO düzeylerinde yükselme ve GPx düzeylerinde azalma gözlendi. Bu konuyu netleştirmek için daha fazla ve kapsamlı çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• Oksidatif stres
• iskemi modifiye albumin
• psoriazis vulgaris

References

1. Sikar Aktürk A, Ozdoğan HK, Bayramgürler D, Cekmen MB, Bilen N, Kıran R. Nitric oxide and malondialdehyde levels in plasma and tissue of psoriasis patients. J Eur Acad Dermatol Venereol. 2012;26(7):833-837. doi:10.1111/j.1468-3083.2011.04164.x
2. Karaca S, Guder H. Antioxidant system in dermatology. Turk J Dermatol. 2009;3(2):32-39.
3. Attwa E, Swelam E. Relationship between smoking-induced oxidative stress and the clinical severity of psoriasis. J Eur Acad Dermatol Venereol. 2011;25(7):782-787. doi:10.1111/j.1468-3083.2010.03860.x
4. Tekin NS, Ilter N, Sancak B, Ozden MG, Gurer MA. Nitric oxide levels in patients with psoriasis treated with methotrexate. Mediators Inflamm. 2006;2006(3):16043. doi:10.1155/MI/2006/16043
5. Gisondi P, Bellinato F, Girolomoni G, Albanesi C. Pathogenesis of chronic plaque psoriasis and ıts ıntersection with cardio-metabolic comorbidities. Front Pharmacol. 2020;11:117. doi:10.3389/fphar.2020.00117
6. Geale K, Henriksson M, Jokinen J, Schmitt-Egenolf M. Association of skin psoriasis and somatic comorbidity with the development of psychiatric illness in a Nationwide SwedishStudy. JAMADermatol. 2020;156(7):795-804.
7. Kimmel GW, Lebwohl M. Psoriasis: Overview and diagnosis. Evidence-Based Psoriasis. 2018:1-16. doi:10.1007/978-3-319-90107-7
8. Badri T, Kumar P, Oakley AM. Plaque psoriasis. [Updated 2021 Aug 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430879/. Accessed Jan 27, 2022.

9. Parisi R, Iskandar IYK, Kontopantelis E, et al. National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study. BMJ. 2020;369:m1590. doi:10.1136/bmj.m1590
10. Ayala-Fontánez N, Soler DC, McCormick TS. Current knowledge on psoriasis and autoimmune diseases. Psoriasis (Auckl). 2016;6:7-32. doi:10.2147/PTT.S64950
11. Ferreira C, Azevedo A, Nogueira M, Torres T. Management of psoriasis in pregnancy - a review of the evidence to date. Drugs Context. 2020;9:2019-11-6. doi:10.7573/dic.2019-11-6
12. Vičić M, Kaštelan M, Brajac I, Sotošek V, Massari LP. Current concepts of psoriasis ımmunopathogenesis. Int J Mol Sci. 2021;22(21):11574. doi:10.3390/ijms222111574
13. Kurutas EB. The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state. Nutr J. 2016;15(1):71. doi:10.1186/s12937-016-0186-5
14. Pleńkowska J, Gabig-Cimińska M, Mozolewski P. Oxidative stress as an ımportant contributor to the pathogenesis of psoriasis. Int J Mol Sci. 2020;21(17):6206. doi:10.3390/ijms21176206
15. Lin X, Huang T. Oxidative stress in psoriasis and potential therapeutic use of antioxidants. Free Radic Res. 2016;50(6):585-95. doi:10.3109/10715762.2016.1162301
16. Asha K, Singal A, Sharma SB, Arora VK, Aggarwal A. Dyslipidaemia & oxidative stress in patients of psoriasis: Emerging cardiovascular risk factors. Indian J Med Res. 2017;146(6):708-713. doi:10.4103/ijmr.IJMR-717-16
17. Paul S, Sen S, Nath I, Kumar A, Biswas UK. Psoriasis, an inflammatory condition associated with oxidative stress. Asian Journal of Medical Sciences, 2021;12(4):24-30. doi:10.3126/ajms.v12i4.33343
18. Kaur M, Sharma S, Kukreja S, Kaur J, Bassi R. Study of oxidative stress in patients of psoriasis. Int J Res Dermatol. 2016;2:95-8. doi:10.18203/issn.2455-4529
19. Srinivas US, Tan BWQ, Vellayappan BA, Jeyasekharan AD. ROS and the DNA damage response in cancer. Redox Biol. 2019;25:101084. doi: 10.1016/j.redox.2018.101084
20. Qing X, Shi D, Lv X, et al. Prognostic significance of 8-hydroxy-2′-deoxyguanosine in solid tumors: A meta-analysis. BMC Cancer. 2019;19:997. doi:10.1186/s12885-019-6189-9
21. Kızılyel O, Akdeniz N, Metin MS, Elmas ÖF. Investigation of oxidant and antioxidant levels in patients with psoriasis. Turk J Med Sci. 2019;49(4):1085-1088. doi:10.3906/sag-1807-257
22. Pektas SD, Pektas G, Oztekin A, et al. Investigation of adropin and IMA levels in psoriasis and their relation to duration and severity of disease. Our Dermatol Online. 2018;9(4):363-368.
23. Kaur M, Sharma S, Kukreja S, Kaur J, Bassi R. Study of oxidative stress in patients of psoriasis. Int J Res Dermatol. 2016;2(4):95-98.
24. Mahmouda A, Abo-Elmaged R , Fahmy H , Nada H. Estimation of nitric oxide level in psoriatic patients and its correlation with disease severity. Egypt J Dermatol Venereol. 2013;33(2):71-75.