The General Characteristics of Hospitalized Patients with the Diagnosis of COVID-19, and the Relationship between Presenting Symptoms and Clinical Course: A Single Center Experience

Abstract

Objective: In this study, it was aimed to reveal the relationship between the clinical features, presenting symptoms, and prognosis of COVID-19 patients who were hospitalized in our center.

Materials and Methods: 499 patients with the diagnosis of COVID-19 followed in the service and intensive care units of Sakarya University Training and Research Hospital between March 2020 and January 2021 were included in the study. The clinical and demographical data of the patients were obtained from the patient files and hospital automation system. The obtained data were analyzed statistically.

Results: Of 499 patients, 171 were followed up in the ward and 328 in the intensive care unit. Follow-up of 230 patients resulted in death, while 269 patients were discharged. Comorbid diseases were found to be more frequently seen in the mortal group (p<0.05). Mean leukocyte, neutrophil, c-reactive protein (CRP), procalcitonin (PCT), lactate dehydrogenase (LDH), ferritin, d-dimer, and troponin values ​​were higher in the mortal group; whereas mean lymphocyte value was found to be lower (p<0.05). While fever, cough, and other less common symptoms (diarrhea, nausea, muscle weakness, etc.) were more frequently seen in the non-mortal group ( p=0.022, p=0.038, and p=0.000 respectively), shortness of breath was significantly more common in the mortal group (p=0.000). The frequency of symptoms such as sputum, fatigue, sore throat, and the headache were found to be similar in both groups (p>0.05).

Conclusion: It was concluded that the clinical course of patients with dyspnea at admission may be more severe and these patients should be followed more closely.

Keywords

• COVID-19
• PROGNOSIS
• mortality
• symptoms

COVID-19 Tanısıyla Hastaneye Yatan Hastaların Genel Karakteristik Özellikleri ve Başvuru Semptomları ile Klinik Seyirleri Arasındaki İlişki: Tek Merkez Deneyimi

Öz

Amaç: Bu çalışmada merkezimizde yatarak tedavi edilmiş hastaların klinik özellikleri ve başvuru semptomları ile prognozları arasındaki ilişkinin ortaya konulması amaçlanmıştır.

Materyal ve Metot: Mart 2020- Ocak 2021 arasında Sakarya Üniversitesi Eğitim ve Araştırma Hastanesi’nde servis ve yoğun bakımlarda COVID-19 tanısıyla takip edilen 499 hasta çalışmaya dahil edildi. Hastaların klinik ve demografik verileri hasta dosyaları ve hastane otomasyon sisteminden elde edildi. Elde edilen veriler istatistiksel olarak değerlendirildi.

Bulgular: 499 hastanın 171’i serviste, 328’i yoğun bakımda takip edilmiştir. 230 hastanın takibi ölümle sonuçlanırken 269 hasta taburcu edilmiştir. Komorbid hastalıklar mortal grupta anlamlı ölçüde daha sık rastlanmıştır (p<0,5). Mortal grupta, ortalama lökosit, nötrofil, c-reaktif protein (CRP), prokalsitonin (PCT), laktat dehidrogenaz (LDH), ferritin, d-dimer ve troponin değerleri daha yüksek; ortalama lenfosit değeri daha düşük saptandı (p<0,05). Başvuru semptomlarından ateş, öksürük ve daha nadir görülen diğer semptomlar (ishal,bulantı, kas güçsüzlüğü vs.) non-mortal grupta daha sık saptanırken (sırasıyla p=0,022, p=0,038 ve p=0,000) nefes darlığı mortal grupta anlamlı ölçüde daha sık saptandı (p=0,000). Balgam, halsizlik, boğaz ağrısı ve baş ağrısı semptomlarının sıklığı her iki grupta benzer olarak bulundu (p>0,05).

Sonuç: Başvuru esnasında nefes darlığı şikayeti olan hastaların klinik seyrinin daha şiddetli olabileceği ve bu hastaların daha yakından takip edilmesi gerektiği sonucuna varılmıştır. 

Anahtar Kelimeler

• COVID-19
• SEMPTOM
• PROGNOZ
• MORTALİTE
• mortality
• symptoms

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