Evaluation of Bone Mineral Density with DEXA in Hyperthyroid Patients Treated with Radioactive Iodine Treatment

Abstract

Objective: In this study, it was aimed to investigate bone mineral density (BMD) and radioactive iodine (RAI) treatment in patients with hyperthyroidism and to evaluate the effects of RAI treatment on BMD. The results were reviewed with current literature. Materials and Methods: Thyroid scintigraphy, thyroid functions, DEXA results of patients were evaluated before and after RAI. Results: Forty-six patients (31 female, 15 male) with a mean age of 58.4±11.1 were studied. Three (7%) patients had Graves' disease (GH), 24 (52%) toxic adenomas (TA), 19 (41%) toxic multinodular goiters (TMNG). Mean values before RAI; TSH 0.005 IU/mL, fT3 12.33 pmol/L, fT4 17.38 pmol/L, vertebral T score (-)1.15, Z score 0.33, BMD 0.99g/cm2, femur T-Score (-)1.30, Z-Score 0, BMD 0.83 was g/cm2. Mean values after RAI; TSH 1.19 IU/mL, fT3 3.44 pmol/L, fT4 11.33 pmol/mL, vertebral T score (-) 0.85, Z score 0.04, BMD 1.03g/cm2, femur T-Score (-)1.0, Z-Score 0.30, BMD 0.87 was g/cm2. Conclusion: RAI can be successfully used in selected patients with hyperthyroidism. The decrease in BMD improves after RAI. The results are consistent with current literature.

Keywords

• Bone mineral density
• hyperthyroidism
• radioactive iodine

Radyoaktif İyot Tedavisi Uygulanan Hipertiroidili Hastalarda Kemik Mineral Yoğunluğunun DEXA ile Değerlendirilmesi

Öz

Amaç: Bu çalışmada hipertiroidili hastalarda kemik mineral yoğunluğu (KMY) ve radyoaktifiyot (RAI) tedavisinin araştırılması ve RAI tedavisinin KMY üzerine etkilerinin değerlendirilmesi amaçlanmıştır. Sonuçlar güncel literatürle gözden geçirildi.

Materyal ve Metot: Hipertiroidi nedeniyle RAİ uygulanan hastaların tedavi öncesi ve sonrası, tiroid sintigrafileri, tiroid fonksiyonları ve kemik dansitometresi sonuçları değerlendirildi.

Bulgular: Yaş ortalaması 58,4±11,1 olan 46 hasta (31 kadın, 15 erkek) incelendi. Hastaların 3’ü (%7) Graves’ hastalığı (GH), 24’ü (%52) toksik adenom (TA), 19’u (%41) toksik multi nodüler guatr (TMNG) idi. RAİ öncesi ortalama değerler; TSH 0.005 IU/mL, sT3 12.33 pmol/L, sT4 17.38 pmol/L, vertebra T skoru (-)1.15, Z skoru 0.33, KMY 0.99g/cm2, femur T Skoru (-)1.30, Z Skoru 0, KMY 0.83g/cm2 idi. RAİ tedavisinden bir yıl sonra ortalama değerler; TSH 1.19 IU/mL, sT3 3.44 pmol/L, sT4 11.33 pmol/mL, vertebra T skoru (-) 0.85, Z skoru 0.04, KMY 1.03g/cm2, femur T Skoru (-)1.0, Z Skoru 0.30, KMY 0.87 g/cm2 idi.

Sonuç: Seçilmiş hipertiroidili hastalarda RAİ başarı ile uygulanabilir. Hipertiroidi sırasında oluşan KMY’deki azalma RAİ sonrası düzelmektedir. Sonuçlar güncel literatürle uyumludur.

Anahtar Kelimeler

• Hipertiroidi
• kemik mineral yoğunluğu
• radyoaktif iyot

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