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The Relationship between Cloninger’s Temperament and Character Dimensions, and Depression Treatment Outcome

Year 2022, , 486 - 492, 01.09.2022
https://doi.org/10.26453/otjhs.1121857

Abstract

Objective: The aim of our study is to investigate the relationship between Temperament and Character Inventory (TCI) dimensions and treatment response in Major Depressive Disorder (MDD) patients.
Materials and Methods: 88 patients diagnosed with MDD were included in the study. Patients were given Sociodemographic Data Form, Beck Depression Inventory (BDI) and TCI before the treatment. According to the BDI, which was applied 8 weeks after the treatment, the patients were divided into two groups as those who responded to the treatment and those who did not (responders and non-responders).
Results: The education level of the patients was statistically higher in the responders. The number of unemployed (92.3%) patients in the non-responders was statistically higher than the number of unemployed (41.3%) patients in the responders. The number of patients with severe depression was statistically significantly higher in the non-responders. The mean harm avoidence score of the patients in the non-responders were found to be statistically higher than in the responders. The mean persistence score of the patients in the responders was found to be statistically higher than the non-responders.
Conclusion: Our study shows that some sociodemographic characteristics and TCI dimensions may be associated with early treatment response in MDD patients.

References

  • World Health Organization WHO. Depression and Other Common Mental Disorders, Global Health Estimates 2017. http://apps.who.int/iris/bitstream/10665/254610/1/WHO-MSD-MER-2017.2-eng.pdf. Accessed March 3,2022.
  • Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, WalterS EE. Lifetime prevalence and age-of-onset distributions of DSM-IVdisorders in the Natioanal Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62(6):593-602. doi:10.1001/archpsyc.62.6.593
  • Dilbaz N, Çavuş SY. Depresyon tedavisinde yetersiz yanıt durumunda güçlendirme tedavileri. Klinik Psikofarmakoloji Bülteni. 2010;20(Suppl. 1):4-14.
  • Cloninger CR, Svrakic DM, Przybeck TR. A psychobiological model of temperament and character. Arch Gen Psychiatry. 1993;50(12):975-990. doi:10.1001/archpsyc.1993.01820240059008
  • Kose S, Yalcin M, Akin E, Turkcapar H. Normative data and factorial structure of the Turkish version of the temperament and character inventory-revised (Turkish TCI-R). Psychiatr Clin Psychopharmacol. 2019;29(2):189-196. doi:10.1080/24750573.2019.1610144
  • Noll R. Styles of Psychiatric Practice, 1906-1925: Clinical evaluations of the same patient by James Jackson Putnam, Adolph Meyer, August Hoch, Emil Kraepelin and Smith Ely Jelliffe. Hist Psychiatry. 1999;10(38Pt2):145-189. doi:10.1177/0957154X9901003801
  • Kampman O, Poutanen O. Can onset and recovery indepression be predicted by temperament? A systematic review and meta-analysis. J Affect Disord. 2011;135(1-3):20-27. doi:10.1016/j.jad.2010.12.021
  • de Winter RFP, Wolterbeek RS, Philip ZFG, Goekoop JG. Character and temperament in major depressive disorder and highly anxious-retarded subtype derived from melancholia. Compr Psychiatry. 2007;48(5):426-435. doi:10.1016/j.comppsych.2007.04.002
  • Balestri M, Porcelli S, Souery D, et al. Temperament and character influence on depression treatment outcome. J Affect Disord. 2019; 252:464-474. doi:10.1016/j.jad.2019.04.031
  • Kampman O, Poutanen O, Illi A, et al. Temperament profiles, major depression, and response to treatment with SSRIs in psychiatric outpatients. Eur Psychiatry. 2012;27(4):245-249. doi:10.1016/j.eurpsy.2010.07.006
  • Paavonen V, Luoto K, Koivukangas A, Lassila A, Leinonen E, Kampman O. Temperament and character profiles associated with depression and treatment response in patients with or without comorbid substance abuse. Psychiatry Res. 2016;245:250-258. doi:10.1016/j.psychres.2016.08.043
  • Akdeniz F. Depresyonda optimal ilaç kullanımı. In: Yazıcı O, Oral ET, Vahip S, Özer Ş, ed. Türkiye Psikiyatri Derneği Depresyon Sağaltım Kılavuzu Kaynak Kitabı. 1st edition. Inc; 2008:71-79.
  • Frank E, Prien R, Jarrett B, et al. Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Arch Gen Psychiatry,1991;48(9):851-855. doi:10.1001/archpsyc.1991.01810330075011
  • Keller MB. Past, present, and future directions for defining optimal treatment outcome in depression: Remission and beyond. JAMA. 2003;289(23):3152-3160. doi:10.1001/jama.289.23.3152
  • Köse S, Sayar K, Ak İ, et al. Mizaç ve karakter envanteri (Türkçe TCI): Geçerlik, güvenirliği ve faktör yapısı. Klinik Psikofarmakoloji Bulteni. 2004;14(3):107-131.
  • Arkar H, Sorias O, Tunca Z, et al. Mizaç ve karakter envanteri’nin Türkçe formunun faktör yapısı, geçerlik ve güvenirliği. Türk Psikiyatri Dergisi. 2015;16(3):190-204.
  • Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561-571. doi:10.1001/archpsyc.1961.01710120031004
  • Hisli N. Beck Depresyon Envanterinin geçerliliği üzerine bir çalışma. Psikoloji Dergisi. 1988;6:118-121.
  • Prasko J, Ociskova M, Grambal A, et al. Personality features, dissociation, self-stigma, hope, and the complex treatment of depressive disorder. Neuropsychiatr Dis Treat. 2016;12:2539–2552. doi:10.2147/NDT.S117037
  • Gronemann FH, Jorgensen MB, Nordentoft M, Andersen PK, Osler M. Socio-demographic and clinical risk factors of treatment-resistant depression: A Danish population-based cohort study. J Affect Disord. 2020;261:221-229. doi:10.1016/j.jad.2019.10.005
  • Tüfekçi B, Karaca S. Examining loneliness, depression and burnout among employees at a factory. Online Turkish Journal of Health Sciences. 2021;6(4):514-520. doi:10.26453/otjhs.882828
  • Kraus C, Kadriu B, Lanzenberger R. Zarate Jr CA, Kasper S. Prognosis and improved outcomes in major depression: A review. Transl Psychiatry. 2019;9(1):127. doi:10.1038/s41398-019-0460-3
  • De Carlo V, Calati R, Serretti A. Socio-demographic and clinical predictors of non-response/non-remission in treatment resistant depressed patients: A systematic review. Psychiatry Res. 2016;240:421-430. doi:10.1016/j.psychres.2016.04.034
  • Perlman K, Benrimoh D, Israel S, et al. A systematic meta-review of predictors of antidepressant treatment outcome in major depressive disorder. J Affect Disord. 2019;243:503-515. doi:10.1016/j.jad.2018.09.067
  • Paavonen V, Kampan O, Illi A, Viikki M, Setala-Soikkeli E, Leinonen E. A cluster model of temperament as an indicator of antidepressant response and symptom severity in major depression. Psychiatry Investig. 2014;11(1):18-23. doi:10.4306/pi.2014.11.1.18
  • Bajraktarov S, Novotni A, Arsova S, Gudeva-Nikovska D, Vujovik V. Character and temperament dimensions in subjects with depressive disorder: Impact of the affective state on their expression. Open Access Maced J Med Sci. 2017;5(1):64–67. doi:10.3889/oamjms.2017.012
  • Zaninotto L, Solmi M, Toffanin T, Veronese N, Cloninger CR, Correll CU. A meta-analysis of temperament and character dimensions in patients with mood disorders: Comparison to healthy controls and unaffected siblings. J Affect Disord. 2016;194:84-97. doi:10.1016/j.jad.2015.12.077
  • Murphy JA, Sarris J, Byrne GJ. A Review of the conceptualisation and risk factors associated with treatment-resistant depression. Depress Res Treat. 2017;2017:4176825. doi:10.1155/2017/4176825
  • Takahashi M, Shirayama Y, Muneoka K, Suzuki M, Sato K, Hashimoto K. Personality traits as risk factors for treatment-resistant depression. PLoS One. 2013;8(5):e63756. doi:10.1371/journal.pone.0063756

Cloninger’in Mizaç ve Karakter Boyutları’nın Depresyon Tedavisi ile İlişkisi

Year 2022, , 486 - 492, 01.09.2022
https://doi.org/10.26453/otjhs.1121857

Abstract

Amaç: Bu çalışmada Majör Depresif Bozukluk hastalarında mizaç ve karakter özelliklerinin, 8 haftalık süreçte tedavi yanıtı üzerine etkileri araştırılması, tedaviye yanıt veren ve vermeyen hasta gruplarında mizaç ve karakter özelliklerinin karşılaştırılması amaçlanmıştır.
Materyal ve Metot: Çalışmaya Majör Depresif Bozukluk tanısı konmuş 88 hasta alınmıştır. Hastalara tedaviye başlamadan önce Sosyodemografik Veri Formu, Mizaç ve Karakter Envanteri ve Beck Depresyon Envanteri uygulanmıştır. Tedavinin başlangıcından 8 hafta sonra uygulanan Beck Depresyon Envanteri’ne göre hastalar tedaviye yanıt veren ve vermeyen hastalar şeklinde iki gruba ayrılarak bu iki grubun mizaç ve karakter özellikleri karşılaştırılmıştır.
Bulgular: Hastaların eğitim düzeyi tedaviye yanıt veren grupta daha yüksektir. 2. gruptaki işsiz ve ev hanımı (92,3) hasta sayısı tedaviye yanıt veren gruptaki işsiz ve ev hanımı (%41,3) hasta sayısından daha fazla bulunmuştur. Şiddetli depresyonu olan hasta sayısı tedaviye yanıt vermeyen grupta istatistiksel olarak anlamlı düzeyde daha yüksektir. Tedaviye yanıt vermeyen gruptaki hastaların zarardan kaçınma puanı ortalaması tedaviye yanıt veren gruba göre istatistiksel olarak daha yüksek bulunmuştur. Tedaviye yanıt veren gruptaki hastaların sebat etme puanı ortalaması tedaviye yanıt vermeyen gruba göre istatistiksel olarak daha yüksek bulunmuştur.
Sonuç: Çalışmamız Majör Depresif Bozukluk hastalarında bazı sosyodemografik özelliklerin ve mizaç ve karakter özelliklerinin erken tedavi yanıtı ile ilişkili olabileceğini göstermektedir.

References

  • World Health Organization WHO. Depression and Other Common Mental Disorders, Global Health Estimates 2017. http://apps.who.int/iris/bitstream/10665/254610/1/WHO-MSD-MER-2017.2-eng.pdf. Accessed March 3,2022.
  • Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, WalterS EE. Lifetime prevalence and age-of-onset distributions of DSM-IVdisorders in the Natioanal Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62(6):593-602. doi:10.1001/archpsyc.62.6.593
  • Dilbaz N, Çavuş SY. Depresyon tedavisinde yetersiz yanıt durumunda güçlendirme tedavileri. Klinik Psikofarmakoloji Bülteni. 2010;20(Suppl. 1):4-14.
  • Cloninger CR, Svrakic DM, Przybeck TR. A psychobiological model of temperament and character. Arch Gen Psychiatry. 1993;50(12):975-990. doi:10.1001/archpsyc.1993.01820240059008
  • Kose S, Yalcin M, Akin E, Turkcapar H. Normative data and factorial structure of the Turkish version of the temperament and character inventory-revised (Turkish TCI-R). Psychiatr Clin Psychopharmacol. 2019;29(2):189-196. doi:10.1080/24750573.2019.1610144
  • Noll R. Styles of Psychiatric Practice, 1906-1925: Clinical evaluations of the same patient by James Jackson Putnam, Adolph Meyer, August Hoch, Emil Kraepelin and Smith Ely Jelliffe. Hist Psychiatry. 1999;10(38Pt2):145-189. doi:10.1177/0957154X9901003801
  • Kampman O, Poutanen O. Can onset and recovery indepression be predicted by temperament? A systematic review and meta-analysis. J Affect Disord. 2011;135(1-3):20-27. doi:10.1016/j.jad.2010.12.021
  • de Winter RFP, Wolterbeek RS, Philip ZFG, Goekoop JG. Character and temperament in major depressive disorder and highly anxious-retarded subtype derived from melancholia. Compr Psychiatry. 2007;48(5):426-435. doi:10.1016/j.comppsych.2007.04.002
  • Balestri M, Porcelli S, Souery D, et al. Temperament and character influence on depression treatment outcome. J Affect Disord. 2019; 252:464-474. doi:10.1016/j.jad.2019.04.031
  • Kampman O, Poutanen O, Illi A, et al. Temperament profiles, major depression, and response to treatment with SSRIs in psychiatric outpatients. Eur Psychiatry. 2012;27(4):245-249. doi:10.1016/j.eurpsy.2010.07.006
  • Paavonen V, Luoto K, Koivukangas A, Lassila A, Leinonen E, Kampman O. Temperament and character profiles associated with depression and treatment response in patients with or without comorbid substance abuse. Psychiatry Res. 2016;245:250-258. doi:10.1016/j.psychres.2016.08.043
  • Akdeniz F. Depresyonda optimal ilaç kullanımı. In: Yazıcı O, Oral ET, Vahip S, Özer Ş, ed. Türkiye Psikiyatri Derneği Depresyon Sağaltım Kılavuzu Kaynak Kitabı. 1st edition. Inc; 2008:71-79.
  • Frank E, Prien R, Jarrett B, et al. Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Arch Gen Psychiatry,1991;48(9):851-855. doi:10.1001/archpsyc.1991.01810330075011
  • Keller MB. Past, present, and future directions for defining optimal treatment outcome in depression: Remission and beyond. JAMA. 2003;289(23):3152-3160. doi:10.1001/jama.289.23.3152
  • Köse S, Sayar K, Ak İ, et al. Mizaç ve karakter envanteri (Türkçe TCI): Geçerlik, güvenirliği ve faktör yapısı. Klinik Psikofarmakoloji Bulteni. 2004;14(3):107-131.
  • Arkar H, Sorias O, Tunca Z, et al. Mizaç ve karakter envanteri’nin Türkçe formunun faktör yapısı, geçerlik ve güvenirliği. Türk Psikiyatri Dergisi. 2015;16(3):190-204.
  • Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561-571. doi:10.1001/archpsyc.1961.01710120031004
  • Hisli N. Beck Depresyon Envanterinin geçerliliği üzerine bir çalışma. Psikoloji Dergisi. 1988;6:118-121.
  • Prasko J, Ociskova M, Grambal A, et al. Personality features, dissociation, self-stigma, hope, and the complex treatment of depressive disorder. Neuropsychiatr Dis Treat. 2016;12:2539–2552. doi:10.2147/NDT.S117037
  • Gronemann FH, Jorgensen MB, Nordentoft M, Andersen PK, Osler M. Socio-demographic and clinical risk factors of treatment-resistant depression: A Danish population-based cohort study. J Affect Disord. 2020;261:221-229. doi:10.1016/j.jad.2019.10.005
  • Tüfekçi B, Karaca S. Examining loneliness, depression and burnout among employees at a factory. Online Turkish Journal of Health Sciences. 2021;6(4):514-520. doi:10.26453/otjhs.882828
  • Kraus C, Kadriu B, Lanzenberger R. Zarate Jr CA, Kasper S. Prognosis and improved outcomes in major depression: A review. Transl Psychiatry. 2019;9(1):127. doi:10.1038/s41398-019-0460-3
  • De Carlo V, Calati R, Serretti A. Socio-demographic and clinical predictors of non-response/non-remission in treatment resistant depressed patients: A systematic review. Psychiatry Res. 2016;240:421-430. doi:10.1016/j.psychres.2016.04.034
  • Perlman K, Benrimoh D, Israel S, et al. A systematic meta-review of predictors of antidepressant treatment outcome in major depressive disorder. J Affect Disord. 2019;243:503-515. doi:10.1016/j.jad.2018.09.067
  • Paavonen V, Kampan O, Illi A, Viikki M, Setala-Soikkeli E, Leinonen E. A cluster model of temperament as an indicator of antidepressant response and symptom severity in major depression. Psychiatry Investig. 2014;11(1):18-23. doi:10.4306/pi.2014.11.1.18
  • Bajraktarov S, Novotni A, Arsova S, Gudeva-Nikovska D, Vujovik V. Character and temperament dimensions in subjects with depressive disorder: Impact of the affective state on their expression. Open Access Maced J Med Sci. 2017;5(1):64–67. doi:10.3889/oamjms.2017.012
  • Zaninotto L, Solmi M, Toffanin T, Veronese N, Cloninger CR, Correll CU. A meta-analysis of temperament and character dimensions in patients with mood disorders: Comparison to healthy controls and unaffected siblings. J Affect Disord. 2016;194:84-97. doi:10.1016/j.jad.2015.12.077
  • Murphy JA, Sarris J, Byrne GJ. A Review of the conceptualisation and risk factors associated with treatment-resistant depression. Depress Res Treat. 2017;2017:4176825. doi:10.1155/2017/4176825
  • Takahashi M, Shirayama Y, Muneoka K, Suzuki M, Sato K, Hashimoto K. Personality traits as risk factors for treatment-resistant depression. PLoS One. 2013;8(5):e63756. doi:10.1371/journal.pone.0063756
There are 29 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research article
Authors

Meltem Gürü 0000-0001-8751-6453

Gül Ferda Cengiz 0000-0003-0919-5708

Sibel Örsel 0000-0003-0184-7038

Publication Date September 1, 2022
Submission Date May 27, 2022
Acceptance Date June 24, 2022
Published in Issue Year 2022

Cite

AMA Gürü M, Cengiz GF, Örsel S. The Relationship between Cloninger’s Temperament and Character Dimensions, and Depression Treatment Outcome. OTSBD. September 2022;7(3):486-492. doi:10.26453/otjhs.1121857

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