Meme Karsinomlarında ER, PR, c-erbB2, Ki67, E-Cadherin Ekspresyonları, Nottingham Histolojik Grade ve Bazı Klinik Parametreler Arasındaki İlişkilerin Değerlendirilmesi

Öz

Amaç: Bu çalışmada meme karsinomlarında Östrojen (ER), Progesteron (PR), c-erbB2 (HER2), Ki67, E-Cadherin ekspresyonları, Nottingham histolojik grade ve bazı klinik parametreler arasındaki ilişkilerin değerlendirilmesi amaçlanmıştır. Materyal ve Metot: Bu çalışmaya 2018-2019 yıllarında patoloji bölümümüzde meme karsinom tanısı alan toplam 74 hasta dahil edildi. İmmünohistokimyasal olarak çalışılan ER, PR, HER2, Ki67, E-Cadherin boyalı preparatlar retrospektif olarak değerlendirilip incelendi. ER ve PR için ≥%1 ekspresyon pozitif boyanma, <%1 ise negatif boyanma olarak kabul edildi. HER2 skor 0, 1, 2 veya 3 olarak değerlendirildi. Ki67 proliferasyon indeksi için <%10, %10-20, >%20 sırasıyla düşük, orta ve yüksek riskli olarak kabul edildi. Çalışmada elde edilen veriler ki-kare testi ile değerlendirildi. Bulgular: HER2 skoru ER durumuna göre istatistiksel olarak anlamlı değişim gösterdi (p=0,010). HER2 skoru PR durumuna göre de istatistiksel olarak anlamlı değişim gösterdi (p=0,004). Ki67 ile histolojik evre arasında anlamlı ilişki vardı (p<0.001). Sonuç: Meme karsinomlarında Ki67 indeksinin yüksek olması kötü prognostik göstergelerdendir. ER, PR ekspresyonunun saptanması ve HER2 ekspresyonunun saptanmaması ise iyi prognostik göstergelerdendir. Preanalitik ve analitik süreçler patologlar tarafından titizlikle takip edilmelidir.

Anahtar Kelimeler

• E-Cadherin
• HER2
• hormon reseptörleri
• Ki67
• meme karsinomu

Evaluation of the Relationships between ER, PR, c-erbB2, Ki67, E-Cadherin Expressions, Nottingham Histological Grade and some Clinical Parameters in Breast Carcinomas

Abstract

Objective: In this study, it was aimed to evaluate the relationships between Estrogen receptor (ER), Progesterone receptor (PR), c-erbB2 (HER2), Ki67, E-Cadherin expressions, Nottingham histological grade and some clinical parameters in breast carcinomas. Materials and Methods: A total of 74 patients diagnosed with breast carcinoma (CA) in our pathology department between 2018-2019 were included in this study. Immunohistochemical preparations stained with ER, PR, HER2, Ki67 and E-Cadherin were evaluated and analyzed retrospectively. For ER and PR, ≥1% expression was considered as positive staining, and <1% was considered as negative staining. HER2 expression was scored as 0, 1, 2 and 3. Ki67 proliferation index was considered as low (<10%), intermediate (10-20%) and high risk (>20%). The data were analyzed with chi-square test. Results: HER2 score showed a statistically significant change according to ER status (p=0.010). HER2 score also showed a statistically significant change according to PR status (p=0.004). There was a significant correlation between Ki67 and histological stage (p<0.001). Conclusions: Detection of high Ki67 index in breast carcinomas is poor prognostic. Detection of ER and PR expression and no expression of HER2 are good prognostic indicators. Preanalytical and analytical processes should be followed meticulously by pathologists.

Keywords

• Breast Carcinoma
• E-Cadherin
• HER2
• Hormone Receptors
• Ki67

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