Koronavirüs Hastalığı Nedeniyle Ölenlerle Taburcu Olanların Beyin Natriüretik Peptit ve Diğer Laboratuvar Parametrelerinin Karşılaştırılması

Öz

Amaç: Bu çalışmada amacımız, COVID-19 enfeksiyonu teşhisi alıp hastanede yatıp taburcu olanlar ile ölen hastaların beyin natriüretik peptidini (BNP) karşılaştırmaktır. Materyal ve Metot: Çalışma COVID-19 hastalığı teşhisi konan 474 hasta üzerinde gerçekleştirildi. Ölen 56 hasta ile taburcu olan 418 COVID-19 hastasının bilgileri hastane bilgi yönetim sisteminden (HBYS) alındı ve geriye dönük olarak analiz edildi. Ölen hastalar ile taburcu olan hastalarda BNP, beyaz küre hücresi (WBC) , nötrofil (NEU), lenfosit (LYM), trombosit (PLT), Procalsitonin (PCT), Yüksek Duyarlı Troponin I (hs Tn I), D-dimer ve C-Reaktif Protein (CRP) düzeyleri arasındaki ilişki araştırıldı. Bulgular: Kadınlar ile erkekler arasında mortalite açısından istatistiksel olarak anlamlı bir fark yoktu (p=0,385). Ölenler ile taburcu olanlar arasında BNP, WBC, NEU, LYM, trombosit, PCT ve hs Tn I değerlerinde istatistiksel olarak anlamlı fark yoktu. Ölenler ile taburcu olanların D-dimer (p<0,031) ve CRP (p<0,020) değerleri istatistiksel olarak anlamlı bulundu. Sonuç: Artan CRP ve D-dimer düzeylerinin mortalite ile ilişkili olduğu bulundu. Bu konuda daha kapsamlı çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• Beyin natriüretik peptid
• C-reactive protein
• D-dimer
• koronavirus enfeksiyonları

Comparison of Brain Natriuretic Peptide and Other Laboratory Parameters of Those Who Died From Coronavirus Disease and Those Who Were Discharged

Abstract

Objectıve: In this study, we aim to compare the brain natriuretic peptide (BNP) of patients who were diagnosed with COVID-19 infection, who were hospitalized and discharged, and those who died. Materials and Methods: The study was conducted on 474 patients diagnosed with COVID-19 disease. Information of 56 patients who died and 418 patients with COVID-19 who were discharged were obtained from the hospital information management system (HIMS) and analyzed retrospectively. The relationship between BNP, white blood cell (WBC), neutrophil (NEU), lymphocyte (LYM), platelet (PLT), Procalcitonin (PCT), High Sensitive Troponin I (hs Tn I), D-dimer and C-Reactive Protein (CRP) levels in deceased patients and discharged patients researched. Results: There was no statistically significant difference in mortality between women and men (p=0.385). There was no statistically significant difference in BNP, WBC, NEU, LYM, platelet, PCT and hs Tn I values between those who died and those who were discharged. D-dimer and CRP values of those who died and discharged were statistically significant (p< 0.031 and 0.020, respectively). Conclusions: Increased levels of CRP and D-dimer were found to be associated with mortality. More comprehensive studies are needed on this subject.

Keywords

• Brain natriüretik peptide
• C-reactive protein
• coronavirus infections
• D-dimer

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