Abstract
İnflamatuar yanıt, yaşa bağlı hastalıkların patofizyolojisinde ve geriatrik hastalarda sağlık sonuçlarında önemli bir rol oynamaktadır. Yaşlı yetişkinlerde inflamasyonun altında yatan mekanizmaları anlamak ve inflamatuar yanıtı modüle etmek için hedefe yönelik müdahaleler geliştirmek, geriatrik popülasyonların sağlığını ve yaşam kalitesini iyileştirmek için umut verici yollar sunabilir.
Keywords
Ethical Statement
Ethics committee approval is not required.
References
- Şahin F, Tekeci MH, Kocayigit H, Palabıyık O, Kochai A. Evaluation of inflammation markers in elderly patients undergoing hip fracture surgery. OTHJS. 2024;9(1):61-65. doi:10.26453/otjhs.1401020
- Li X, Li C, Zhang W, Wang Y, Qian P, Huang H. Inflammation and aging: Signaling pathways and intervention therapies. Signal Transduct Target Ther. 2023;8(1):239. doi:10.1038/s41392-023-01502-8
- Özdemir S. Inflammation: Complexity and significance of cellular and molecular responses. J Acute Dis. 2024;13(1):3-7. doi:10.4103/jad.jad_129_23
- Nidadavolu LS, Walston JD. Underlying vulnerabilities to the sytokine storm and adverse COVID-19 outcomes in the aging immune system. J Gerontol A Biol Sci Med Sci. 2021;76(3):e13-e18. doi:10.1093/gerona/glaa209
- Kale SS, Yende S. Effects of aging on inflammation and hemostasis through the continuum of critical illness. Aging Dis. 2011;2(6):501-511.
- Zhu P, Ke ZR, Chen JX, Li SJ, Ma TL, Fan XL. Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment. Front Immunol. 2023;14:1120034. doi:10.3389/fimmu.2023.1120034
- Sorrenti V, Benedetti F, Buriani A, et al. Immunomodulatory and antiaging mechanisms of resveratrol, rapamycin, and metformin: Focus on mTOR and AMPK signaling networks. Pharmaceuticals. 2022;15(8):912. doi:10.3390/ph15080912
Abstract
The inflammatory response plays a pivotal role in the pathophysiology of age-related diseases and health outcomes in geriatric patients. Understanding the mechanisms underlying inflammation in older adults and developing targeted interventions to modulate the inflammatory response may offer promising avenues for improving the health and quality of life of geriatric populations.
Ethical Statement
Ethics committee approval is not required.
References
- Şahin F, Tekeci MH, Kocayigit H, Palabıyık O, Kochai A. Evaluation of inflammation markers in elderly patients undergoing hip fracture surgery. OTHJS. 2024;9(1):61-65. doi:10.26453/otjhs.1401020
- Li X, Li C, Zhang W, Wang Y, Qian P, Huang H. Inflammation and aging: Signaling pathways and intervention therapies. Signal Transduct Target Ther. 2023;8(1):239. doi:10.1038/s41392-023-01502-8
- Özdemir S. Inflammation: Complexity and significance of cellular and molecular responses. J Acute Dis. 2024;13(1):3-7. doi:10.4103/jad.jad_129_23
- Nidadavolu LS, Walston JD. Underlying vulnerabilities to the sytokine storm and adverse COVID-19 outcomes in the aging immune system. J Gerontol A Biol Sci Med Sci. 2021;76(3):e13-e18. doi:10.1093/gerona/glaa209
- Kale SS, Yende S. Effects of aging on inflammation and hemostasis through the continuum of critical illness. Aging Dis. 2011;2(6):501-511.
- Zhu P, Ke ZR, Chen JX, Li SJ, Ma TL, Fan XL. Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment. Front Immunol. 2023;14:1120034. doi:10.3389/fimmu.2023.1120034
- Sorrenti V, Benedetti F, Buriani A, et al. Immunomodulatory and antiaging mechanisms of resveratrol, rapamycin, and metformin: Focus on mTOR and AMPK signaling networks. Pharmaceuticals. 2022;15(8):912. doi:10.3390/ph15080912
Details
| Primary Language | English |
|---|---|
| Subjects | Emergency Medicine |
| Journal Section | Letter to the Editor |
| Authors | |
| Early Pub Date | December 21, 2024 |
| Publication Date | December 25, 2024 |
| Submission Date | April 30, 2024 |
| Acceptance Date | October 16, 2024 |
| Published in Issue | Year 2024 |
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